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Cytogenetic evaluation of 20 sporadic breast cancer patients and their first degree relatives.

Abstract：

:Many genetic abnormalities disclosed even in somatic cells like peripheral blood lymphocytes may mark footprint(s) of malignancy(ies). The present cytogenetic study on peripheral blood lymphocytes of sporadic breast cancer patients (n = 20) and their first degree relatives (n = 39) reports abnormalities of chromosomes 16, 5, 12, and 17 respectively in 17.59%, 8.33%, 6.48%, and 5.57% cells of patients and 15.83%, 8.33%, 7.5%, and 5% cells of their first degree relatives. These common chromosomal abnormalities pave the way to assume why first degree relatives of sporadic breast cancer patients are at increased risk of developing the same or other malignancies.

journal_name

Breast Cancer Res Treat

journal_title

Breast cancer research and treatment

authors

Trivedi AH,Roy SK,Bhachech SH,Patel RK,Dalal AA,Bhatavdekar JM,Patel DD

doi

10.1023/a:1005951125574

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

187-90

issue

2

eissn

0167-6806

issn

1573-7217

journal_volume

48

pub_type

杂志文章

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