Growth factor targeted and conventional therapy of breast cancer.

Abstract:

:Sustained breast cancer growth and metastasis requires paracrine signals between the tumor cells and the normal surrounding host tissue. One crucial function of these signals is to recruit endothelial cells and thus new blood vessels for the nourishment of the expanding tumor mass. This proliferation and migration of endothelial cells in the vicinity of progressing tumors contrasts with the extremely low turn-over rate of endothelial cells in the healthy adult. A blockade of tumor-induced endothelial cell proliferation should inhibit tumor growth and potentially metastasis with only few adverse effects. Different therapeutic approaches that take advantage of this situation are discussed with respect to their interaction with conventional therapies of breast cancer.

authors

Wellstein A

doi

10.1007/BF00666148

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

141-51

issue

2-3

eissn

0167-6806

issn

1573-7217

journal_volume

31

pub_type

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