Abstract:
:Bone marrow transplantation is known to be associated with considerable morbidity and mortality. The aim of this study was to determine the influence of nutritional status and development of sick euthyroid syndrome as prognostic factors for outcome after BMT. In 100 patients who underwent transplantation the following parameters were assessed before and at day 14 and 28 after transplantation: anthropometric data (body weight, body mass index, body composition, grip strength), rapid turnover proteins transferrin and prealbumin, T4, T3, free T4, reverse T3, thyroid-stimulating hormone and thyroglobulin. Following bone marrow transplantation, 22 patients died in the short-term follow-up (group A) before day 140 after BMT, 21 patients died during further follow-up between days 140 and 365 (group B) and 57 patients survived longer than 365 days (group C). All patients experienced a significant decrease of transferrin and T3, accompanied by an increase of rT3 and rT3/T3 ratio at day 14 after BMT. At day 28 after BMT, patients in group C showed recovery from these changes with an increase of transferrin and a fall in rT3 and the rT3/T3-ratio, which was not seen in patients who died during further follow-up (groups A and B). The observed changes were independent of other prognostically relevant factors (type of disease, HLA-match, immunosuppression). Impaired nutritional status and development of a sick euthyroid syndrome, without tendency to recovery, are associated with a higher probability of fatal outcome after bone marrow transplantation and have prognostic relevance in this group of patients.
journal_name
Bone Marrow Transplantjournal_title
Bone marrow transplantationauthors
Schulte C,Reinhardt W,Beelen D,Mann K,Schaefer Udoi
10.1038/sj.bmt.1701502subject
Has Abstractpub_date
1998-12-01 00:00:00pages
1171-8issue
12eissn
0268-3369issn
1476-5365journal_volume
22pub_type
杂志文章abstract::Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive...
journal_title:Bone marrow transplantation
pub_type: 杂志文章,多中心研究
doi:10.1038/bmt.2008.195
更新日期:2008-10-01 00:00:00
abstract::Multiple myeloma (MM) is characterized by the expansion of tumor plasma cells in bone marrow (BM), but neoplastic cells have been consistently detected in peripheral blood (PB). Peripheral blood progenitor cell (PBPC) collections have been widely used to support high-dose therapy for MM patients. A flow cytometric tec...
journal_title:Bone marrow transplantation
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doi:10.1038/sj.bmt.1702085
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abstract::The number of individuals undergoing unrelated cord blood transplantation (UCBT) has increased in recent years; however, information on prognostic factors is limited. We retrospectively analyzed data from 475 children and adolescents receiving UCBT with myeloablative conditioning for acute lymphoblastic leukemia (ALL)...
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doi:10.1038/s41409-020-01019-6
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:10.1038/sj.bmt.1705751
更新日期:2007-09-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:10.1038/sj.bmt.1705218
更新日期:2006-01-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章,多中心研究
doi:10.1038/bmt.2010.121
更新日期:2011-03-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:10.1038/bmt.2013.31
更新日期:2013-09-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/sj.bmt.1704759
更新日期:2005-02-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:10.1038/s41409-020-01005-y
更新日期:2021-01-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:10.1038/bmt.2017.121
更新日期:2017-09-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章,评审
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更新日期:2016-11-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:10.1038/bmt.2016.343
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journal_title:Bone marrow transplantation
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更新日期:2021-01-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-10-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:10.1038/sj.bmt.1703725
更新日期:2002-11-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:10.1038/bmt.2008.209
更新日期:2008-10-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:10.1038/sj.bmt.1701396
更新日期:1998-09-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:
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journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章
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journal_title:Bone marrow transplantation
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
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更新日期:1992-12-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
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更新日期:2000-05-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章
doi:
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journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章,评审
doi:10.1038/bmt.2015.261
更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00