Abstract:
:Data from human clinical trials and animal experiments have suggested that T lymphocytes in donor marrow help to facilitate engraftment after allogeneic bone marrow transplantation, possibly through a suppressive effect on the immunity of the recipient. In previous studies marrows from HLA-identical donors were treated ex vivo with a mixture of eight monoclonal antibodies together with rabbit complement to achieve a 3-log depletion of T cells and CD3-negative lymphoid cells. Transplantation of this marrow was associated with a 27% actuarial risk of graft failure in leukemic recipients conditioned with cyclophosphamide (120 mg/kg) and 15.75 Gy fractionated total body irradiation. In the present study, we employed an anti-CD3 ricin A-chain-containing immunotoxin (64.1-A) together with 20 mM NH4Cl to achieve a selective 3-log depletion of CD3-positive cells. The patient entry criteria and pretransplant conditioning regimen were identical to those used in previous studies. Despite the differences in marrow treatment, the clinical outcome of the present study was similar to that obtained previously. Graft-versus-host disease (GVHD) was largely prevented without the need for post-transplant immunosuppression, but two of the eight patients developed graft failure. These results indicate that CD3-negative cells have little or no ability to initiate GVHD. To the extent that graft failure in this study was not caused by stem cell damage or loss of CD3-negative cells during ex vivo processing of the marrow, it appears that the lymphoid cells required for facilitating allogeneic engraftment under these conditions are CD3-positive.
journal_name
Bone Marrow Transplantjournal_title
Bone marrow transplantationauthors
Martin PJ,Hansen JA,Torok-Storb B,Moretti L,Press O,Storb R,Thomas ED,Weiden PL,Vitetta ESsubject
Has Abstractpub_date
1988-09-01 00:00:00pages
437-44issue
5eissn
0268-3369issn
1476-5365journal_volume
3pub_type
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
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journal_title:Bone marrow transplantation
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2016-01-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章
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更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-09-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章,评审
doi:
更新日期:1990-07-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:10.1038/sj.bmt.1705351
更新日期:2006-05-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:10.1038/sj.bmt.1701537
更新日期:1999-01-01 00:00:00
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journal_title:Bone marrow transplantation
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doi:10.1038/sj.bmt.1701227
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journal_title:Bone marrow transplantation
pub_type: 临床试验,杂志文章
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更新日期:1997-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/s41409-020-01075-y
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pub_type: 杂志文章
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
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journal_title:Bone marrow transplantation
pub_type: 杂志文章
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更新日期:1996-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-11-01 00:00:00
abstract::Infectious complications were retrospectively analyzed in 129 transplants, performed in 90 patients, to identify characteristics that qualify breast cancer patients for outpatient-based PBSCT. Thirty-one cases (24%) did not develop fever. Of the remaining 98 cases, 84.7% developed fever during severe neutropenia. On u...
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pub_type: 杂志文章
doi:10.1038/sj.bmt.1703246
更新日期:2001-11-01 00:00:00
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