[Ciprofloxacin levels in pleural fluid and serum during systemic administration after pneumonectomy].

Abstract:

:Postpneumonectomy empyema represents a frequently lethal complication. It remains unsolved whether prophylactic antibiotics achieve a bactericidal concentration in the pleural cavity after pneumonectomy. 12 patients undergoing pneumonectomy received ciprofloxacin intravenously (2 x 200 micrograms/d) and orally (2 x 500 micromilligrams/d) during the first and second postoperative week, respectively. 1, 6, 9 and 14 days after the operation the ciprofloxacin concentration was measured in the pleural fluid and serum. Already after 24 hours bactericidal levels (0.56 microgram/ml) were found in the pleural fluid, rising to 1.11 micrograms/ml on day 14 under the higher oral dosage. Thus, it could be demonstrated that during the first two weeks after pneumonectomy high concentrations of an antibiotic similar to the levels in the serum can be achieved in the pleural fluid.

journal_name

Zentralbl Chir

authors

Padberg WM,Jäger E,Buhr J,Zimmermann T

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

450-3

issue

5

eissn

0044-409X

issn

1438-9592

journal_volume

125

pub_type

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  • [Locking plate osteosynthesis for fractures of the proximal humerus].

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