Voltammetric analysis of certain 4-quinolones in pharmaceuticals and biological fluids.

Abstract:

:The voltammetric behaviour of Enrofloxacin (I), Sparfloxacin (II) and Fleroxacin (III) was studied using direct current (DCt), differential pulse (DPP) and alternating current (ACt). All the drugs manifest cathodic waves in Britton Robinson buffer over the pH range of 4.0-11.98. The waves were characterized as being irreversible, diffusion-controlled with limited adsorption properties. The diffusion current concentration relationships were found to be rectilinear over the ranges 4 x 10(-5) x 10(-4) M, 1 x 10(-5)-2 x 10(-4) M, 1 x 10(-5)-4 x 10(-4) M using DCt mode for I, II and III, respectively and 1 x 10(-6)-4 x 10(-5) M, 1 x 10(-6)-1 x 10(-4) M, and 2 x 10(-6)-8 x 10(-5) M, using DPP mode for I, II and III respectively, with minimum detectability (S/N = 3) of 1 x 10(-7) M for I, II and 2 x 10(-7) M for III. The proposed method was successfully applied to the determination of the studied compounds either per se or in formulations and biological fluids. The results obtained were concordant to those given using reference methods.

journal_name

J Pharm Biomed Anal

authors

Rizk M,Belal F,Ibrahim F,Ahmed S,El-Enany NM

doi

10.1016/s0731-7085(00)00401-5

subject

Has Abstract

pub_date

2000-12-15 00:00:00

pages

211-8

issue

2

eissn

0731-7085

issn

1873-264X

pii

S0731-7085(00)00401-5

journal_volume

24

pub_type

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