当前位置： SCI文献检索 > JOURNAL OF VASCULAR SURGERY期刊下所有文献 > Inhibition of inducible nitric oxide synthase limits nitric oxide production and experimental aneurysm expansion.

Inhibition of inducible nitric oxide synthase limits nitric oxide production and experimental aneurysm expansion.

Abstract：

PURPOSE:Nitric oxide (NO), frequently cited for its protective role, can also generate toxic metabolites known to degrade elastin. Both abdominal aortic aneurysms (AAAs) and inducible nitric oxide synthase (iNOS) are associated with inflammatory states, yet the relationship between NO production by iNOS and AAA development is unknown. The current study examines iNOS expression, NO production, and the effects of selective inhibition of iNOS by aminoguanidine in experimental AAA. METHODS:An intra-aortic elastase infusion model was used. Control rats received intra-aortic saline infusion and postoperative intraperitoneal saline injections (Group 1). In the remaining groups, intra-aortic elastase infusion was used to induce aneurysm formation. These rats were treated with intraperitoneal injections of saline postoperatively (Group 2), aminoguanidine postoperatively (Group 3), or aminoguanidine preoperatively and postoperatively (Group 4). Aortic diameter and plasma nitrite/nitrate levels were measured on the day of surgery and postoperative day 7. Aortas were harvested for biochemical and histologic analysis on postoperative day 7. RESULTS:Infusion of elastase produced AAAs (P <.001) with significant production of iNOS (P <.05) and nitrite/nitrate (P <.003) compared with controls. Selective inhibition of iNOS with aminoguanidine in elastase-infused aortas significantly reduced aneurysm size (P <.01) compared with elastase infusion alone. Aminoguanidine-treated rats displayed suppression of iNOS expression and plasma nitrite/nitrate production not significantly different from the control group. Histologic evaluation revealed equivalent inflammatory infiltrates in elastase-infused groups. CONCLUSION:Expression of iNOS is induced and plasma nitrite/nitrate levels are increased in experimental AAA. Inhibition of iNOS limits NO production and iNOS expression, resulting in smaller aneurysm size. NO production by iNOS plays an important role with detrimental effects during experimental aneurysm development.

journal_name

J Vasc Surg

journal_title

Journal of vascular surgery

authors

Johanning JM,Franklin DP,Han DC,Carey DJ,Elmore JR

doi

10.1067/mva.2001.111805

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

579-86

issue

3

eissn

0741-5214

issn

1097-6809

pii

S0741-5214(01)04362-2

journal_volume

33

pub_type

杂志文章

相关文献

JOURNAL OF VASCULAR SURGERY文献大全
  • The role of the kallikrein-kinin system, matrix metalloproteinases, and tissue inhibitors of metalloproteinases in the early restenosis of covered stents in the femoropopliteal arterial segment.

    abstract：OBJECTIVE:The purpose of this study was to investigate the roles of the kallikrein-kinin system and matrix metalloproteinases (MMPs) in the development of arterial restenosis attributable to intimal hyperplasia in the femoropopliteal arteries. METHODS:This report describes a single-center prospective study of 27 patie...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2016.06.106

    authors： Rocha LA,Piccinato CE,Ribiero MS,Becari C,Joviliano RD,Joviliano EE

    更新日期：2017-01-01 00:00:00

  • Successful ventricular transapical thoracic endovascular graft deployment in a pig model.

    abstract：PURPOSE:Aortoiliac occlusive disease may preclude retrograde thoracic endovascular aortic repair. This study evaluated the physiologic and anatomic feasibility of introducing an aortic endograft in an antegrade manner into the descending thoracic aorta of a pig through the left ventricular apex. METHODS:Twelve adult p...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2008.06.043

    authors： Grenon SM,MacDonald S,Sidhu RS,Reid JD,Cheung A,Hsiang Y,Clement J

    更新日期：2008-11-01 00:00:00

  • Clinical and technical factors influencing recurrent carotid stenosis and occlusion after endarterectomy.

    abstract：:Carotid endarterectomy was performed in 152 patients during a 27-month period. The first 82 patients had primary closure of the arteriotomy, whereas the subsequent 70 patients underwent closure with Dacron patch angioplasty. Duplex scanning was undertaken postoperatively in 102 of these patients with a mean follow-up ...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：

    authors： Ouriel K,Green RM

    更新日期：1987-05-01 00:00:00

  • Factors associated with abdominal compartment syndrome complicating endovascular repair of ruptured abdominal aortic aneurysms.

    abstract：BACKGROUND:Endovascular treatment of ruptured abdominal aortic aneurysms (r-AAAs) has the potential to offer improved outcomes. As our experience with endovascular repair of r-AAA evolved, we recognized that the development of abdominal compartment syndrome (ACS) led to an increase in morbidity and mortality. We theref...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2005.08.033

    authors： Mehta M,Darling RC 3rd,Roddy SP,Fecteau S,Ozsvath KJ,Kreienberg PB,Paty PS,Chang BB,Shah DM

    更新日期：2005-12-01 00:00:00

  • Noninvasive blood flow measurement in expanded polytetrafluoroethylene grafts for hemodialysis access.

    abstract：:Volume flow rates were measured in 31 expanded polytetrafluoroethylene grafts (6 mm) of 26 patients undergoing hemodialysis. Flow was calculated from the known access graft diameter and by measurement of the mean Doppler shift frequency waveform. Overall flow rates were 750 +/- 383 ml/min (range, 0 to 1921 ml/min). Th...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：

    authors： Rittgers SE,Garcia-Valdez C,McCormick JT,Posner MP

    更新日期：1986-04-01 00:00:00

  • A personal experience with direct reconstruction and extra-anatomic bypass for aortoiliofemoral occlusive disease.

    abstract：OBJECTIVE:This study was conducted to investigate factors influencing the outcome of all open operations for aortoiliofemoral (AIF) revascularization performed by a single surgeon at a tertiary referral center. METHODS:The series included 355 direct reconstructions and 181 extra-anatomic bypass (EAB) grafts in 339 men...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2006.09.065

    authors： Hertzer NR,Bena JF,Karafa MT

    更新日期：2007-03-01 00:00:00

  • Successful management of tracheo-innominate artery fistula with endovascular stent graft repair.

    abstract：:Tracheo-innominate artery fistula is a highly lethal complication after tracheostomy. A 37-year-old man who had undergone a tracheostomy 14 years earlier because of dysphagia after brain surgery had a tracheo-innominate artery fistula with exsanguinating hemorrhage from his tracheostomy site. After temporary control o...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1067/mva.2001.114997

    authors： Deguchi J,Furuya T,Tanaka N,Nobori M,Seki Y,Nomura Y,Umehara I,Saito H,Miyata T

    更新日期：2001-06-01 00:00:00

  • Prospective assessment of health-related quality of life after endovascular repair of pararenal and thoracoabdominal aortic aneurysms using fenestrated-branched endografts.

    abstract：OBJECTIVE:The objective of this study was to investigate changes in health-related quality of life (QOL) in patients treated for pararenal aortic aneurysms (PAAs) and thoracoabdominal aortic aneurysms (TAAAs) with fenestrated-branched endovascular aneurysm repair (F-BEVAR). METHODS:A total of 159 consecutive patients ...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2018.07.060

    authors： Kärkkäinen JM,Sandri GA,Tenorio ER,Macedo TA,Hofer J,Gloviczki P,Cha S,Oderich GS

    更新日期：2019-05-01 00:00:00

  • Left ventricular hypertrophy is a possible biomarker for early mortality after type B aortic dissection.

    abstract：OBJECTIVE:Data regarding the cardiac abnormalities associated with Stanford type B aortic dissection (TBAD) and whether these abnormalities are related to outcomes are limited. We describe the prevalence of cardiac abnormalities in patients with TBAD as detected by echocardiography. METHODS:This retrospective review i...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2018.09.050

    authors： Taylor AP,Freeman RV,Bartek MA,Shalhub S

    更新日期：2019-06-01 00:00:00

  • Surgical revascularization versus endovascular therapy for chronic mesenteric ischemia: a comparative experience.

    abstract：INTRODUCTION:Endovascular therapy (percutaneous transluminal angioplasty [PTA] with stenting) has been increasingly applied in patients with chronic mesenteric ischemia (CMI) to avoid morbidities associated with open repair (OR). The purpose of this study was to compare outcomes of PTA/Stent vs OR in patients with symp...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2007.01.067

    authors： Atkins MD,Kwolek CJ,LaMuraglia GM,Brewster DC,Chung TK,Cambria RP

    更新日期：2007-06-01 00:00:00

  • Temporin A as a prophylactic agent against methicillin sodium-susceptible and methicillin sodium-resistant Staphylococcus epidermidis vascular graft infection.

    abstract：OBJECTIVE:The purpose of this study was to investigate the efficacy of temporin A as a prophylactic agent in a rat model of vascular graft infection from methicillin sodium-susceptible and methicillin sodium-resistant Staphylococcus epidermidis. METHODS:The prospective, randomized, controlled animal study set in a res...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1067/mva.2002.127530

    authors： Ghiselli R,Giacometti A,Cirioni O,Mocchegiani F,Orlando F,Kamysz W,Del Prete MS,Lukasiak J,Scalise G,Saba V

    更新日期：2002-11-01 00:00:00

  • Congenital superior mesenteric artery aneurysm in a 6-week-old infant presenting with upper gastrointestinal bleeding.

    abstract：:Visceral artery aneurysms are rare in infants and children. The majority of cases are caused by genetic syndromes, trauma, or infection. Although the majority of aneurysms are asymptomatic, visceral artery aneurysms can present with abdominal pain, nausea/vomiting, or rupture. Aneurysm rupture can manifest as hemodyna...

    journal_title：Journal of vascular surgery

    pub_type：

    doi：10.1016/j.jvs.2019.06.106

    authors： Subbaraj L,Beleniski F,Courtier J,Vartanian S,Nijagal A

    更新日期：2020-04-01 00:00:00

  • Epithelioid hemangioendothelioma of the radial artery.

    abstract：:Epithelioid hemangioendothelioma (EHE) is an extremely rare vascular tumor of intermediate malignancy. Generally it develops from the peripheral veins (usually the femoral vein). We report on a case of EHE of the radial artery, developed in a 26-year-old male patient, which presented as a solitary painless mass. He ha...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2004.10.036

    authors： Castelli P,Caronno R,Piffaretti G,Tozzi M

    更新日期：2005-01-01 00:00:00

  • Vascular Quality of Life Questionnaire-6 facilitates health-related quality of life assessment in peripheral arterial disease.

    abstract：BACKGROUND:Most commonly used outcome measures in peripheral arterial disease (PAD) provide scarce information about achieved patient benefit. Therefore, patient-reported outcome measures have become increasingly important as complementary outcome measures. The abundance of items in most health-related quality of life ...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jvs.2013.08.099

    authors： Nordanstig J,Wann-Hansson C,Karlsson J,Lundström M,Pettersson M,Morgan MB

    更新日期：2014-03-01 00:00:00

  • Outcomes of open repair of postdissection abdominal aortic aneurysms.

    abstract：BACKGROUND:Evidence to guide management of postdissection abdominal aortic aneurysms (PDAAA) is lacking. This study describes the outcomes of open repair of PDAAA. METHODS:A retrospective cohort study was conducted of all consecutive patients treated with open repair for PDAAA after a Stanford type A or type B thoraci...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jvs.2019.04.483

    authors： Vos CG,van Lammeren GW,Werson DAB,Wille J,Kropman RHJ,Vahl AC,Voûte MT,de Vries JPM

    更新日期：2020-03-01 00:00:00

  • The association between lipoprotein-associated phospholipase A2 and cardiovascular disease and total mortality in vascular medicine patients.

    abstract：INTRODUCTION:In some community-based studies, lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) has been shown to be independently predictive of future fatal and nonfatal cardiovascular disease (CVD) events. We tested the hypothesis that Lp-PLA(2) is independently predictive of mortality in high-risk patients from ...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2007.04.038

    authors： Allison MA,Denenberg JO,Nelson JJ,Natarajan L,Criqui MH

    更新日期：2007-09-01 00:00:00

  • A comparison between one- and two-stage brachiobasilic arteriovenous fistulas.

    abstract：OBJECTIVES:Brachiobasilic arteriovenous fistulas (BBAVF) can be performed in one or two stages. We compared primary failure rates, as well as primary and secondary patency rates of one- and two-stage BBAVF at two institutions. METHODS:Patients undergoing one- and two-stage BBAVF at two institutions were compared retro...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2011.01.064

    authors： Reynolds TS,Zayed M,Kim KM,Lee JT,Ishaque B,Dukkipati RB,Kaji AH,de Virgilio C

    更新日期：2011-06-01 00:00:00

  • Biochemical analysis of a human humoral fibroblast inhibitory factor associated with impaired vascular prosthetic graft incorporation.

    abstract：:A specific inhibitory factor was isolated from human serum of a patient who manifested impaired prosthetic graft tissue incorporation. The latter reaction was hypothesized to be related to inhibiting fibroblast proliferation by a specific humoral factor. The crude inhibitory serum was tested against a pool of normal h...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：

    authors： Schneiderman J,Knoller S,Adar R,Savion N

    更新日期：1991-07-01 00:00:00

  • Temporary extra-anatomic brain perfusion followed by total rerouting of the supra-aortic vessels for hybrid repair of a ruptured aortic arch aneurysm.

    abstract：:Hybrid repair of ruptured aortic arch repair has been proposed as a valuable approach. However, the presence of an anterior mediastinal hematoma must be carefully detected because of the inherent risk of rupture at sternotomy. We report the case of a patient presenting a ruptured aortic arch aneurysm with anterior rup...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2011.03.271

    authors： Joyeux F,Canaud L,Hireche K,Berthet JP,Marty-Ane C,Alric P

    更新日期：2011-10-01 00:00:00

  • Prolonged renal artery occlusion after endovascular aneurysm repair: endovascular rescue and renal function salvage.

    abstract：:Albeit uncommon, delayed renal dysfunction after endovascular abdominal aortic aneurysm repair (EVAR) can be attributed to proximal stent graft migration or unrecognized partial renal artery coverage. We report two patients who were found to have renal artery occlusion 1 week after EVAR with Zenith (Cook, Bloomington,...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2007.08.019

    authors： Hedayati N,Lin PH,Lumsden AB,Zhou W

    更新日期：2008-02-01 00:00:00

  • Mortality and reintervention following elective abdominal aortic aneurysm repair.

    abstract：BACKGROUND:The objective of this study is to provide an up-to-date meta-analysis on the short- and long-term mortality rates of elective repair of abdominal aortic aneurysms (AAAs) via the open and endovascular approaches. METHODS:MEDLINE, EMBASE, and Cochrane Central Register of Controlled trials, conference proceedi...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章,评审

    doi：10.1016/j.jvs.2013.02.013

    authors： Qadura M,Pervaiz F,Harlock JA,Al-Azzoni A,Farrokhyar F,Kahnamoui K,Szalay DA,Rapanos T

    更新日期：2013-06-01 00:00:00

  • Characterization of perioperative contralateral stroke after carotid endarterectomy.

    abstract：OBJECTIVE:Contralateral stroke is an infrequent cause of perioperative stroke after carotid endarterectomy (CEA). Whereas the risks of ipsilateral stroke complicating CEA have been discriminated, factors that lead to contralateral stroke are poorly defined. The purpose of this study was to identify the risk of perioper...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2017.04.059

    authors： Clouse WD,Ergul EA,Patel VI,Lancaster RT,LaMuraglia GM,Cambria RP,Conrad MF

    更新日期：2017-11-01 00:00:00

  • Visceral lipid peroxidation occurs at reperfusion after supraceliac aortic cross-clamping.

    abstract：PURPOSE:Recently, we have reported that lipid peroxidation specific to oxygen free radical-mediated injury increased immediately after reperfusion of human liver allografts. However, in the human liver transplantation setting it was impossible to disassociate the contributions to lipid peroxidation caused by the warm a...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/s0741-5214(94)70074-5

    authors： Kazui M,Andreoni KA,Williams GM,Perler BA,Bulkley GB,Beattie C,Donham RT,Sehnert SS,Burdick JF,Risby TH

    更新日期：1994-03-01 00:00:00

  • Discovering overtreatment: second-opinion dilemma.

    abstract：:An experienced vascular surgeon, Dr Al Wright, specializing in venous disease, often sees self-referred patients seeking second opinions primarily for ablation therapy and is deeply disturbed at what he finds. Some patients have no reflux on ultrasound examination and, thus, no treatment is indicated. Others were told...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2014.10.026

    authors： Jones JW,McCullough LB

    更新日期：2014-12-01 00:00:00

  • Academic medical centers write their own rules.

    abstract：:The interaction between pharmaceutical and device companies and hospitals and physicians has undergone significant transformation in the past few years due to the public's perception that bias may result when such relationships are not disclosed and monitored. Policies need to be written by medical centers and hospita...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2011.04.067

    authors： Freischlag JA

    更新日期：2011-09-01 00:00:00

  • Dose-dependent neuroprotection of delta-opioid peptide [D-Ala(2), D-Leu(5)] enkephalin on spinal cord ischemia-reperfusion injury by regional perfusion into the abdominal aorta in rabbits.

    abstract：OBJECTIVE:In our prior study, we showed that delta-opioid peptide [D-Ala(2), D-Leu(5)] enkephalin (DADLE), by regional perfusion into the abdominal aorta, could protect the spinal cord against ischemia-reperfusion (I/R) injury caused by aortic occlusion. However, the relative dose-response effects of DADLE still remain...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2014.11.074

    authors： Liu H,Chen B,Li S,Yao J

    更新日期：2016-04-01 00:00:00

  • Midterm results of endovascular stented grafts for the treatment of isolated iliac artery aneurysms.

    abstract：PURPOSE:Isolated aneurysms of the iliac arteries are uncommon lesions that require surgical repair to prevent rupture. METHODS:During a 4-year period, we used endovascular stented grafts (EGs) to treat 28 iliac artery aneurysms that were not associated with aortic aneurysms. Twenty-five patients, with a total of 24 co...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/s0741-5214(99)70017-0

    authors： Parsons RE,Marin ML,Veith FJ,Parsons RB,Hollier LH

    更新日期：1999-11-01 00:00:00

  • Multiple organ dysfunction after mesenteric artery revascularization.

    abstract：PURPOSE:Mesenteric arterial reconstruction in patients with acute or chronic intestinal ischemia is associated with significant morbidity and mortality rates. Reperfusion of ischemic bowel in animals leads to release of multiple factors that cause organ dysfunction. Similar phenomena potentially occur in human beings a...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1067/mva.1993.48586

    authors： Harward TR,Brooks DL,Flynn TC,Seeger JM

    更新日期：1993-09-01 00:00:00

  • Hospital vascular surgery volume and procedure mortality rates in California, 1982-1994.

    abstract：PURPOSE:Little is known about the long-term growth and outcomes of vascular surgery procedures over time. Trends in the use of three major vascular surgery procedures by a general population-lower extremity arterial bypass (LEAB), carotid endarterectomy (CEA), and abdominal aortic aneurysm repair (AAA)-are described. T...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/s0741-5214(98)70199-5

    authors： Manheim LM,Sohn MW,Feinglass J,Ujiki M,Parker MA,Pearce WH

    更新日期：1998-07-01 00:00:00

  • Use of antibiotic-loaded polymethylmethacrylate beads for the treatment of extracavitary prosthetic vascular graft infections.

    abstract：PURPOSE:This study was conducted to assess the efficacy of antibiotic-loaded polymethylmethacrylate (PMMA) beads in the management of lower extremity extracavitary prosthetic arterial graft infection. METHODS:This was a retrospective review of 34 patients treated for vascular surgical site (VSS) infections involving 3...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2006.05.056

    authors： Stone PA,Armstrong PA,Bandyk DF,Brumberg RS,Flaherty SK,Back MR,Johnson BL,Shames ML

    更新日期：2006-10-01 00:00:00