Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation.

abstract：:A patient with brainstem infarction met the clinical criteria for brain death but had persistent EEG activity, complicating our decision to withdraw life support. We evaluated cerebral blood flow with xenon-enhanced computed tomography (Xe/CT), which documented the absence of posterior circulation flow and persistent,...

journal_title：Critical care medicine

authors： Darby J,Yonas H,Brenner RP

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVES:In patients with acute hypoxemic respiratory failure, noninvasive ventilation and high-flow nasal cannula oxygen are alternative strategies to conventional oxygen therapy. Endotracheal intubation is frequently needed in these patients with a risk of delay, and early predictors of failure may help clinicians ...

journal_title：Critical care medicine

authors： Frat JP,Ragot S,Coudroy R,Constantin JM,Girault C,Prat G,Boulain T,Demoule A,Ricard JD,Razazi K,Lascarrou JB,Devaquet J,Mira JP,Argaud L,Chakarian JC,Fartoukh M,Nseir S,Mercat A,Brochard L,Robert R,Thille AW,REV

更新日期：2018-02-01 00:00:00

abstract：:Patients (n = 158) who had been respirator-treated and who could remember the treatment were retrospectively (after greater than 2 months) interviewed about their experiences. Of all patients, 47% had felt anxiety and/or fear during the treatment. These feelings were intimately related to the experience of agony/panic...

journal_title：Critical care medicine

authors： Bergbom-Engberg I,Haljamäe H

更新日期：1989-10-01 00:00:00

abstract：OBJECTIVE:To prospectively evaluate the oxygenation effect of inhaled nitric oxide (INO) delivered during high-frequency oscillatory ventilation in adult patients with the acute respiratory distress syndrome and oxygenation failure. DESIGN Prospective, clinical study. SETTING:Intensive care unit of a university teachi...

journal_title：Critical care medicine

authors： Mehta S,MacDonald R,Hallett DC,Lapinsky SE,Aubin M,Stewart TE

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:To evaluate the impact of a comprehensive unit-based safety program on safety climate in a large cohort of intensive care units participating in the Keystone intensive care unit project. DESIGN/SETTING:A prospective cohort collaborative study to improve quality of care and safety culture by implementing and...

journal_title：Critical care medicine

authors： Sexton JB,Berenholtz SM,Goeschel CA,Watson SR,Holzmueller CG,Thompson DA,Hyzy RC,Marsteller JA,Schumacher K,Pronovost PJ

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVES:To assess the amount of nutrients delivered, prescribed, and required for critically ill patients and to identify the reasons for discrepancies between prescriptions and requirements and between prescriptions and actual delivery of nutrition. DESIGN:Prospective cohort study. SETTING:Twelve-bed medical inte...

journal_title：Critical care medicine

authors： De Jonghe B,Appere-De-Vechi C,Fournier M,Tran B,Merrer J,Melchior JC,Outin H

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Rapid fluid loading is standard treatment for hypovolemia. Because volume expansion does not always improve hemodynamic status, predictive parameters of fluid responsiveness are needed. Passive leg raising is a reversible maneuver that mimics rapid volume expansion. Passive leg raising-induced changes in stro...

journal_title：Critical care medicine

authors： Préau S,Saulnier F,Dewavrin F,Durocher A,Chagnon JL

更新日期：2010-03-01 00:00:00

abstract：:Twenty-seven surgical patients who developed post-extubation hypoxemia unresponsive to routine respiration therapy (incentive spirometry and chest physical therapy) received continuous positive airway pressure (CPAP) delivered through a mask at an inspired oxygen fraction (FIO2) of 0.45. All patients responded with an...

journal_title：Critical care medicine

authors： Dehaven CB Jr,Hurst JM,Branson RD

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVES:Lung-protective ventilation for acute respiratory distress syndrome aims for providing sufficient oxygenation and carbon dioxide clearance, while limiting the harmful effects of mechanical ventilation. "Flow-controlled ventilation", providing a constant expiratory flow, has been suggested as a new lung-prote...

journal_title：Critical care medicine

authors： Schmidt J,Wenzel C,Spassov S,Borgmann S,Lin Z,Wollborn J,Weber J,Haberstroh J,Meckel S,Eiden S,Wirth S,Schumann S

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:Recently, the definition of sepsis has changed from a physiologic derangement (Sepsis-1 and -2) to organ dysfunction (Sepsis-3) based. We sought to determine the concordance between the different sepsis phenotypes and how that affected mortality. DESIGN:Retrospective, multicenter study. SETTING:Three acade...

journal_title：Critical care medicine

authors： Engoren M,Seelhammer T,Freundlich RE,Maile MD,Sigakis MJG,Schwann TA

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Cytokine response after cardiac surgery may be genetically influenced. A study was carried out to investigate the relation between cytokine gene expression in peripheral blood mononuclear cells, genotype, and clinical events after cardiac surgery. DESIGN:A case-control study was performed. SETTING:Cardiac i...

journal_title：Critical care medicine

authors： Duggan E,Caraher E,Gately K,O'Dwyer M,McGovern E,Kelleher D,McManus R,Ryan T

更新日期：2006-08-01 00:00:00

abstract：:High-frequency jet ventilation using a jet injector located at the right mainstem bronchus was superimposed on standard mechanical ventilation to ventilate the injured lung of a patient with unilateral massive atelectasis secondary to pulmonary hemorrhage. This technique of differential ventilation markedly improved a...

journal_title：Critical care medicine

authors： Nishimura M,Takezawa J,Nishijima MK,Taenaka N,Shimada Y,Yoshiya I,Fujimoto Y

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVE:Information booklets have not been assessed by the families of intensive care unit (ICU) patients. This study explored the information that the relatives of adult ICU patients wanted to find in the information booklets. DESIGN:Multicenter survey. SETTING:Twenty-three French ICUs. SUBJECTS:One close relativ...

journal_title：Critical care medicine

authors： Soltner C,Lassalle V,Galienne-Bouygues S,Pottecher J,Floccard B,Delapierre L,Jungfer F,Sargentini C,Alberti C,Beydon L,Lifrea Group.

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To determine the risk factors for development of severe hypoglycemia (defined as glucose <40 mg/dL) in critically ill patients and define the outcomes of this complication. DESIGN:Retrospective database review, including a case-control analysis that matched each patient with severe hypoglycemia with three co...

journal_title：Critical care medicine

authors： Krinsley JS,Grover A

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:The genetic background of hypertensive crisis is unknown. We examined the association of polymorphisms in genes involved in the renin-angiotensin-aldosterone-system with hypertensive crisis. DESIGN:Population-based case-control study. SETTING:Emergency department at a tertiary care university hospital. PAT...

journal_title：Critical care medicine

authors： Sunder-Plassmann G,Kittler H,Eberle C,Hirschl MM,Woisetschläger C,Derhaschnig U,Laggner AN,Hörl WH,Födinger M

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVES:To measure temporal trends in survival over time in people with severe coronavirus disease 2019 requiring critical care (high dependency unit or ICU) management, and to assess whether temporal variation in mortality was explained by changes in patient demographics and comorbidity burden over time. DESIGN:Re...

journal_title：Critical care medicine

authors： Dennis JM,McGovern AP,Vollmer SJ,Mateen BA

更新日期：2021-02-01 00:00:00

abstract：:Calcium chloride is administered frequently to critically ill patients to improve cardiac output and BP. However, Ca has been implicated in the pathophysiology of shock and ischemic disorders. To test the hypothesis that Ca may be deleterious to shock outcome, we studied the effects of CaCl and Ca chelator (EGTA) infu...

journal_title：Critical care medicine

authors： Malcolm DS,Zaloga GP,Holaday JW

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVES:: To characterize the epidemiology and burden of early-onset, nonnosocomial candidemia. DESIGN:: Retrospective review of Cardinal Health Outcomes Research Database, which comprises all acute care admissions at participating hospitals. SETTING:: A total of 176 acute care hospitals. PATIENTS:: All patients ...

journal_title：Critical care medicine

authors： Shorr AF,Gupta V,Sun X,Johannes RS,Spalding J,Tabak YP

更新日期：2009-09-01 00:00:00

abstract：:A 77-yr-old white man recovering from aortobiiliac bypass surgery suffered a sudden stroke within 30 min after carotid sinus massage was performed in an attempt to treat supraventricular tachycardia. Even though carotid digital subtraction angiography and angiograms were negative for carotid artery disease, we believe...

journal_title：Critical care medicine

authors： Bastulli JA,Orlowski JP

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVES:Sepsis results in organ dysfunction caused by a dysregulated host response, in part related to the immune response of a severe infection. Mesenchymal stromal cells are known to modulate the immune response, and expression of stromal cell-derived factor-1 regulates mobilization of neutrophils from the bone ma...

journal_title：Critical care medicine

authors： Kwon MY,Ghanta S,Ng J,Tsoyi K,Lederer JA,Bronson RT,El-Chemaly S,Chung SW,Liu X,Perrella MA

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Prolonged stay in the intensive care unit (ICU) is associated with high mortality, morbidity, and costs. Identifying those patients who are most likely to benefit from an extended ICU stay would be helpful in guiding clinical decisions. We sought to describe the characteristics and outcomes for a heterogeneou...

journal_title：Critical care medicine

authors： Martin CM,Hill AD,Burns K,Chen LM

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVES:Less than half of the thousands of children who suffer in-hospital cardiac arrests annually survive, and neurologic injury is common among survivors. Hemodynamic-directed cardiopulmonary resuscitation improves short-term survival, but its impact on longer term survival and mitochondrial respiration-a potenti...

journal_title：Critical care medicine

authors： Lautz AJ,Morgan RW,Karlsson M,Mavroudis CD,Ko TS,Licht DJ,Nadkarni VM,Berg RA,Sutton RM,Kilbaugh TJ

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:Swallowing disorders may be associated with adverse clinical outcomes in patients following invasive mechanical ventilation. We investigated the incidence of dysphagia, its time course, and association with clinically relevant outcomes in extubated critically ill patients. DESIGN:Prospective observational t...

journal_title：Critical care medicine

authors： Schefold JC,Berger D,Zürcher P,Lensch M,Perren A,Jakob SM,Parviainen I,Takala J

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:This pilot study was designed to identify which contextual factors facilitate/hinder the implementation of the awakening, breathing, coordination, delirium, and early mobility (ABCDE) bundle for guidance in future studies. DESIGN:The sources of data for this study included document review, planned site visit...

journal_title：Critical care medicine

authors： Carrothers KM,Barr J,Spurlock B,Ridgely MS,Damberg CL,Ely EW

更新日期：2013-09-01 00:00:00

abstract：:Seven dogs with electromagnetic flow probes implanted on their main (QT) and left (QL) pulmonary arteries, had catheters placed in their left atria and pulmonary artery, and were ventilated via Carlen's double-lumen endotracheal tubes. The effect of high-frequency oscillation (HFO) on the redistribution of pulmonary b...

journal_title：Critical care medicine

authors： Hall SM,Strawn WB,Levitzky MG

更新日期：1984-05-01 00:00:00

abstract：OBJECTIVE:To investigate the impact of circulating histones on cardiac injury and dysfunction in a murine model and patients with sepsis. DESIGN:Prospective, observational clinical study with in vivo and ex vivo translational laboratory investigations. SETTING:General ICU and university research laboratory. SUBJECTS...

journal_title：Critical care medicine

authors： Alhamdi Y,Abrams ST,Cheng Z,Jing S,Su D,Liu Z,Lane S,Welters I,Wang G,Toh CH

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To determine whether any advantage exists using racemic epinephrine instead of the more potent and less expensive levo(1)-epinephrine in the treatment of postextubation laryngeal edema. DESIGN:Prospective, double-blind, randomized study. SETTING:Pediatric intensive care unit in a university teaching hospita...

journal_title：Critical care medicine

authors： Nutman J,Brooks LJ,Deakins KM,Baldesare KK,Witte MK,Reed MD

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:To directly compare the cerebrovascular effects of norepinephrine and dopamine in patients with acute traumatic brain injury. DESIGN:Prospective randomized crossover trial. SETTING:Neurosciences critical care unit of a university hospital. PATIENTS:Ten acutely head-injured patients requiring vasoactive dru...

journal_title：Critical care medicine

authors： Steiner LA,Johnston AJ,Czosnyka M,Chatfield DA,Salvador R,Coles JP,Gupta AK,Pickard JD,Menon DK

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVES:Despite the universal proliferation of emergency medical services programs throughout the United States since 1970, only a few have ever documented a valid lifesaving effect, particularly in large, urban centers. The purpose of this study was to demonstrate the effect of specialized physician supervision on ...

journal_title：Critical care medicine

authors： Pepe PE,Mattox KL,Duke JH,Fisher PB,Prentice FD

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVES:The association between tobacco smoke exposure and critical illness is not well studied, largely because obtaining an accurate smoking history from critically ill patients is difficult. Biomarkers can provide quantitative data on active and secondhand cigarette smoke exposure. We sought to compare cigarette ...

journal_title：Critical care medicine

authors： Hsieh SJ,Ware LB,Eisner MD,Yu L,Jacob P 3rd,Havel C,Goniewicz ML,Matthay MA,Benowitz NL,Calfee CS

更新日期：2011-01-01 00:00:00