Abstract：
:Resistance to activated protein C (RAPC) is a newly recognized hypercoagulable state that was first described in 1993. It has become apparent that RAPC is even more common than deficiencies in protein C, protein S, or antithrombin III (AT-III) and affects an estimated 5% of the general population. The majority of patients with RAPC have an abnormality in factor V (Arg506Gln), which renders factor Va resistant to degradation by activated protein C. Studies in 75 patients referred to the Hematology Laboratory at Walter Reed Army Institute of Research (WRAIR) over a 14-month period for evaluation of venous thromboembolism were reviewed to determine the percentage of those with RAPC. Of the 75 patients in the study, one was deficient in protein S, one was deficient in protein C, and none was deficient in AT-III. In contrast, 27 (36%) patients tested positive for RAPC. Blood was available for DNA analysis in 15 patients with RAPC. Of these 15 patients, nine (60%) tested positive for the Arg506Gln mutation in factor V. Six other patients with RAPC did not have the factor V mutation. Additional risk factors for thrombosis were immobility, obesity, use of oral contraceptives, and pregnancy. The majority of patients had deep venous thrombosis of the lower extremities; 71% had a recurrence if not placed on chronic anticoagulation therapy. Thus RAPC is a significant risk factor for venous thrombosis. Evaluation for inherited hypercoagulable states should include testing for this newly described condition.
journal_name
Ann Vasc Surgjournal_title
Annals of vascular surgeryauthors
Gillespie DL,Carrington LR,Griffin JH,Alving BMdoi
10.1007/BF02000762subject
Has Abstractpub_date
1996-03-01 00:00:00pages
174-7issue
2eissn
0890-5096issn
1615-5947pii
S0890-5096(06)60468-8journal_volume
10pub_type
杂志文章abstract：:Venous thrombosis of pancreas transplant allografts often leads to graft loss. It is an worrisome complication and difficult to treat, forming the most common nonimmunological cause of graft loss. Multiple risk factors have been implicated in the development of venous thrombosis of pancreas transplant. Color Doppler u...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2016.11.021
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Takayasu arteritis (TA) is a rare, systemic, inflammatory vasculitis of granulomatous nature, and still of unknown etiology. It mainly involves the aorta and its major branches and is more commonly seen in women of childbearing age and Asians. TA leads to stenosis, occlusion, or aneurysmal degeneration of la...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1016/j.avsg.2016.02.011
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Surgical site infections (SSIs) are a significant burden to patients and health care systems. This retrospective study evaluates the observed rates of SSI after our institution implemented chlorhexidine gluconate-impregnated (CHG) cloth as a preoperative antiseptic preparation in elective vascular surgery. ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2016.11.011
更新日期：2017-08-01 00:00:00
abstract：:Thoracic endovascular aortic repair (TEVAR) can be complicated by graft collapse, endoleaks, and stent migration. The incidence of these complications and other outcomes is poorly understood in young trauma victims who receive endovascular aortic repair of blunt thoracic aortic injury (BTAI). A 29-year-old pedestrian ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2016.12.007
更新日期：2017-07-01 00:00:00
abstract：:The aim of this study was to present a case of iatrogenic thromboembolectomy-related tibialis anterior false aneurysm (FA) treated with endovascular FA exclusion and anterior leg compartment (ALC) operative decompression and to assess the current management options in posttraumatic leg vessel FAs. A 68-year-old man ha...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1016/j.avsg.2012.09.013
更新日期：2013-10-01 00:00:00
abstract：:We report herein a feasibility study of a minimally invasive endovascular femoropopliteal bypass procedure. The steps include the following: (1) a small groin incision to expose the femoral artery, (2) guidewire passage and mechanical dilatation of the diseased superficial femoral artery, (3) semiclosed endarterectomy...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/BF02015314
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:The cumulative amount of iodinated contrast medium necessary for endovascular repair (EVAR) planning, operative procedure, and subsequent follow-up is a threat for the onset of end-stage renal disease in patients with preoperative impaired kidney function. The purpose of this study was to describe a mini-inv...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2017.06.050
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Endovascular treatment of aortoiliac occlusive disease (AIOD) involving the aortic bifurcation is challenging. The gold standard is open surgery with patency rates up to 90% at 5 years, but has considerable morbidity and mortality. The kissing stent (KS) technique was introduced as an alternative. The goal o...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1016/j.avsg.2017.01.009
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Leiomyosarcoma of the inferior vena cava (IVC) is a rare mesenchymal tumor with poor prognosis. Surgical resection is currently the only potential curative treatment. This study analyzed long-term outcomes of patients who underwent surgical resection of leiomyosarcoma of the IVC. METHODS:The charts of 12 pa...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2019.05.053
更新日期：2019-11-01 00:00:00
abstract：:Iatrogenic injury of the inferior vena cava (IVC) is a rare event with potentially devastating sequelae. Only a handful of case reports are available in the literature describing successful endovascular techniques to manage this complication. We present the case of a patient with injury to the retrohepatic IVC resulti...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2014.04.009
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Treatment of venous ulcers is demanding for patients, as well as clinicians, and the investigation of underlying venous hypertension is the cornerstone of therapy. We propose that occult iliac vein stenosis should be ruled out by iliac vein interrogation (IVI) in patients with advanced venous stasis. METHOD...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2015.11.036
更新日期：2016-07-01 00:00:00
abstract：:Although the left flank retroperitoneal incision is a useful approach for many patients undergoing major aortic reconstruction for aneurysmal and occlusive disease, it has been associated with weakening of the flank muscles, resulting in bulges varying from slight asymmetry to huge hernias. The purpose of this study w...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s10016-006-9021-3
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:Spinal cord ischemia (SCI) after abdominal aortic aneurysm (AAA) endovascular abdominal aortic aneurysm repair (EVAR) is a rare but devastating complication. The mechanism underlying the occurrence of SCI after EVAR seems to be multifactorial and is underreported and not fully elucidated. The aim of the stud...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2018.03.042
更新日期：2018-10-01 00:00:00
abstract：:Postoperative neurologic deficit is the most devastating complication after thoracoabdominal aortic aneurysm repair. Our aim was to investigate whether nebivolol has protective effects during ischemia or reperfusion and the most effective mechanism of protection via inhibiting nitric oxide (NO) release with an NO synt...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2007.12.024
更新日期：2008-05-01 00:00:00
abstract：:OMNEX (Ethicon, Inc.; Somerville, NJ) is a cyanoacrylate-based synthetic surgical sealant. To date, the use of OMNEX has only been described in a limited number of vascular surgery procedures. We present the cases of two patients who underwent successful extracorporeal renal artery aneurysm repair with the aid of OMNE...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2011.07.009
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:The safety and effectiveness of using venovenous and cardiopulmonary bypass for resection of the inferior vena cava (IVC) is not well studied. The goal of this study was to compare outcomes following IVC resection with and without bypass support. METHODS:We analyzed all patients undergoing IVC resection at ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2015.05.009
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Considering new guidelines for retrievable inferior vena cava filters (IVCFs), we examine our initial experience after establishing a comprehensive filter removal program in our level 1 trauma center. We evaluated the technical and financial feasibility of this program and barriers to IVCF retrieval, includi...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2014.05.018
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:To evaluate the effectiveness and patient satisfaction with the use of oxybutynin for treating axillary hyperhidrosis in a large series of patients. METHODS:One hundred two patients with axillary hyperhidrosis were treated with oxybutynin. During the first week, patients received 2.5 mg of oxybutynin once a...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2011.06.007
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Smartphone apps provide novel ways for triggering lifestyle change by coupling objective measurements of health behavior with tailored feedback. Little is known about end-user preferences regarding the content of mobile health (mHealth) interventions. The aim of this study was to assess smartphone use and pr...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2017.08.020
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:There is increasing recognition that decreased reserve in multiple organ systems, known as accumulated deficits (AD), may better stratify perioperative risk than traditional risk indices. We hypothesized that an AD model would predict both perioperative adverse events and long-term survival after carotid end...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2017.06.150
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:To develop and verify a risk predictive model/scoring system for pulmonary embolism (PE) among hospitalized patients with deep venous thrombosis of the lower extremities (LDVT). METHODS:776 patients with LDVT were enrolled in a case-control study between January 2016 and June 2017 from the Vascular Surgery ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2019.12.008
更新日期：2020-07-01 00:00:00
abstract：:We report the endovascular management of a patient with a type B aortic dissection complicated by renal ischemia and resultant severe hypertension. A 69-year-old male presented with acute type B aortic dissection with proximal extension complicated by severe renovascular hypertension secondary to left renal ischemia. ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s10016-001-0184-7
更新日期：2002-05-01 00:00:00
abstract：:Carotidynia is a term that is best defined by neck pain associated with tenderness over the carotid artery. The differential diagnosis of this entity is broad and includes vascular disorders such as carotid dissection, aneurysm, occlusion, and arteritis. We describe the first reported case of carotidynia caused by sep...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1007/s10016-001-0402-3
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND:Surgical bypass as treatment for chronic mesenteric ischemia (CMI) is performed to alleviate symptoms of weight loss and postprandial pain and to prevent catastrophic intestinal necrosis. Among the studies that report outcomes for mesenteric bypass, few focus on the type of conduit. The purpose of this study...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.avsg.2011.11.006
更新日期：2012-05-01 00:00:00
abstract：:To determine the prevalence, demographics and morbidity of vein patch rupture, the authors polled members of the Western Vascular Society. Forty-eight surgeons (53% of the members) reported an experience with 23,873 carotid operations. A vein patch was used in 1,760 operations (7.4%), and rupture of the patch occurred...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/BF02021782
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Transcarotid artery revascularization (TCAR) has been shown to have half the rates of transient ischemic attack (TIA), stroke, and death compared with transfemoral carotid artery stenting (TFCAS). Successful outcomes of TFCAS require careful patient selection. The aim of this study was to determine the outco...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2020.04.016
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:We reviewed our experience to determine the effect of epidural versus intravenous analgesia on postoperative pulmonary function and pain control in patients with chronic obstructive pulmonary disease (COPD) undergoing open surgery for abdominal aortic aneurysm. METHODS:A retrospective study with prospective...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2011.04.009
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Percutaneous mechanical thrombectomy is commonly used to treat acute thrombotic syndromes. AngioJet (AJ) forcibly sprays fibrinolytics to fragment and aspirate thrombus. It is known to cause hemolysis and gross hematuria, yet potential consequences to renal function after AJ remain unstudied. We sought to de...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2016.12.018
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:The pathophysiological mechanisms that induce postrevascularization edema after femoropopliteal bypass surgery are not completely understood. Reperfusion-associated injury to revascularized tissue and damage to lymphatic structures are both likely to play a role. Aim of this study was to study edema formatio...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2011.04.010
更新日期：2012-02-01 00:00:00
abstract：:The immediate inflammatory response following aortic reconstruction with two types of sealed Dacron grafts was studied in a prospective, randomized manner. C-reactive protein (CRP) levels were measured before surgery and on days 2 and 8 postoperatively. In the collagen-sealed group (n = 10) CRP levels were 10 +/- 9.6,...
journal_title：Annals of vascular surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02139657
更新日期：1995-03-01 00:00:00
