Relationship of early readings of minimal inhibitory concentrations to the results of overnight tests.

abstract：:GSQ1530 is a compound derived from a newly identified class of antibiotics referred to as heteroaromatic polycyclic (HARP) antibiotics. The aim of this study was to assess the in vitro antimicrobial activity of GSQ1530. By using an NCCLS broth microdilution assay, the activities of GSQ1530 and other antibiotics were c...

journal_title：Antimicrobial agents and chemotherapy

authors： Ge Y,Difuntorum S,Touami S,Critchley I,Bürli R,Jiang V,Drazan K,Moser H

更新日期：2002-10-01 00:00:00

abstract：:Mutants of feline immunodeficiency virus (FIV) were selected in cell culture in the continuous presence of 10 microM (each) 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI). These mutants (AIR-1 and AIR-3) displayed a 13-fold resistance to AZT but had less than a 2-fold decrease in susceptibility to ddI...

journal_title：Antimicrobial agents and chemotherapy

authors： Gobert JM,Remington KM,Zhu YQ,North TW

更新日期：1994-04-01 00:00:00

abstract：:A cytochrome P-450-deficient mutant of Candida albicans, strain D10, was employed to study the mode of action of imidazole antifungal agents. This mutant accumulates exclusively 14-alpha-methylsterols, resulting in a sterol profile which mimics that of azole-treated wild-type strains. Since the widely accepted primary...

journal_title：Antimicrobial agents and chemotherapy

authors： Lees ND,Broughton MC,Sanglard D,Bard M

更新日期：1990-05-01 00:00:00

abstract：:Among respiratory tract isolates of Streptococcus pneumoniae from children, resistance to penicillins, cephalosporins, macrolides, and trimethoprim-sulfamethoxazole (SXT) increases on an annual basis. Pediatric patients who do not respond to conventional therapy for respiratory tract infections someday may be treated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Karlowsky JA,Thornsberry C,Critchley IA,Jones ME,Evangelista AT,Noel GJ,Sahm DF

更新日期：2003-06-01 00:00:00

abstract：:3-Decynoyl-N-acetylcystamine is known to inhibit the in vitro growth of Escherichia coli but not of yeasts or mammalian cells. Neither the free acid nor the 2 positional isomer is active (L. R. Kass, J. Biol. Chem. 243:3223-3228, 1968). Other studies have shown that 2-hexadecynoic acid is fungitoxic whereas most of th...

journal_title：Antimicrobial agents and chemotherapy

authors： Konthikamee W,Gilbertson JR,Langkamp H,Gershon H

更新日期：1982-11-01 00:00:00

abstract：:The hepatitis C virus (HCV) replicon is a unique system for the development of a high-throughput screen (HTS), since the analysis of inhibitors requires the quantification of a decrease in a steady-state level of HCV RNA. HCV replicon replication is dependent on host cell factors, and any toxic effects may have a sign...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Boyle DR 2nd,Nower PT,Lemm JA,Valera L,Sun JH,Rigat K,Colonno R,Gao M

更新日期：2005-04-01 00:00:00

abstract：:A membrane fraction from Pseudomonas aeruginosa KM 338 was shown to catalyze in vitro peptidoglycan synthesis from uridine 5'-diphosphate-N-acetylmuramyl-l-alanyl-d- glutamyl-meso-diaminopimelyl-d-alanyl-d-alanine and uridine 5'-diphosphate-N-acetylglucosamine. Synthesized peptidoglycan was partially cross-linked by t...

journal_title：Antimicrobial agents and chemotherapy

authors： Suginaka H,Ichikawa A,Kotani S

更新日期：1974-12-01 00:00:00

abstract：:Doxycycline is reported to impair second-generation parasite schizogony. The effects of doxycycline alone and combined with dihydroartemisinin were investigated in a murine malaria model. Doxycycline lowered the rate of parasite growth within 2 days, with maximum effect in 6 days. Addition of dihydroartemisinin led to...

journal_title：Antimicrobial agents and chemotherapy

authors： Batty KT,Law AS,Stirling V,Moore BR

更新日期：2007-12-01 00:00:00

abstract：:The objective of the present study was to test the hypothesis that treatment of schistosomiasis mansoni with praziquantel can alter significantly the immune response of patients and generate a reversal of the level of fibrosis. Peripheral blood mononuclear cell (PBMC) samples were collected from, and abdominal ultraso...

journal_title：Antimicrobial agents and chemotherapy

authors： Martins-Leite P,Gazzinelli G,Alves-Oliveira LF,Gazzinelli A,Malaquias LC,Correa-Oliveira R,Teixeira-Carvalho A,Silveira AM

更新日期：2008-08-01 00:00:00

abstract：:The minimal inhibitory concentrations of 45 antimicrobial agents were determined for 14 strains of Bacterium actinomycetem comitans (Actinobacillus actinomycetem-comitans). All the strains showed good susceptibility to tetracyclines and chloramphenicol, but not to lincomycins. Some strains were clearly resistant to pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Höffler U,Niederau W,Pulverer G

更新日期：1980-06-01 00:00:00

abstract：:We have reported previously that methylenecyclopropane analogs of nucleosides have excellent activity against certain members of the herpesvirus family. A second generation, the 2,2-bis-hydroxymethyl derivatives, were synthesized, and 18 compounds were tested for activity in vitro against herpes simplex virus types 1 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Kushner NL,Hartline CB,Williams-Aziz SL,Harden EA,Zhou S,Zemlicka J,Prichard MN

更新日期：2005-03-01 00:00:00

abstract：:Visceral leishmaniasis is a neglected tropical disease that causes significant morbidity and mortality worldwide. Characterization of the pharmacokinetics and pharmacodynamics of antileishmanial drugs in preclinical models is important for drug development and use. Here we investigated the pharmacodynamics and drug di...

journal_title：Antimicrobial agents and chemotherapy

authors： Voak AA,Harris A,Qaiser Z,Croft SL,Seifert K

更新日期：2017-08-24 00:00:00

abstract：:The polyene antifungal amphotericin B (AmB) is widely used to treat life-threatening fungal infections. Even though AmB resistance is exceptionally rare in fungi, most Aspergillus terreus isolates exhibit an intrinsic resistance against the drug in vivo and in vitro. Heat shock proteins perform a fundamental protectiv...

journal_title：Antimicrobial agents and chemotherapy

authors： Blatzer M,Blum G,Jukic E,Posch W,Gruber P,Nagl M,Binder U,Maurer E,Sarg B,Lindner H,Lass-Flörl C,Wilflingseder D

更新日期：2015-07-01 00:00:00

abstract：:Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae isolates have been increasingly reported worldwide, and therapeutic options to treat infections caused by these organisms are limited. We evaluated the activity of ceftazidime-avibactam and comparators against 456 Enterobacteriaceae isolates carryi...

journal_title：Antimicrobial agents and chemotherapy

authors： Castanheira M,Mendes RE,Sader HS

更新日期：2017-02-23 00:00:00

abstract：:The activity of clavulanic acid alone and in combination with penicillin, amoxycillin, and carbenicillin was studied. Marked reductions in the minimum inhibitory concentrations (MICs) for a wide spectrum of beta-lactamase-producing clinical isolates were found. Of particular interest were the decreased MICs of penicil...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM,Bedford KA

更新日期：1978-03-01 00:00:00

abstract：:The purpose of this work was to evaluate the in vitro possibilities of ampicillin-ceftriaxone combinations for 10 Enterococcus faecalis strains with high-level resistance to aminoglycosides (HLRAg) and to assess the efficacy of ampicillin plus ceftriaxone, both administered with humanlike pharmacokinetics, for the tre...

journal_title：Antimicrobial agents and chemotherapy

authors： Gavaldà J,Torres C,Tenorio C,López P,Zaragoza M,Capdevila JA,Almirante B,Ruiz F,Borrell N,Gomis X,Pigrau C,Baquero F,Pahissa A

更新日期：1999-03-01 00:00:00

abstract：:Mitochondrial dysfunction in pathogenic fungi or model yeast causes altered susceptibilities to antifungal drugs. Here we have characterized the role of mitochondrial complex I (CI) of Candida albicans in antifungal susceptibility. Inhibitors of CI to CV, except for CII, increased the susceptibility of both patient an...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun N,Fonzi W,Chen H,She X,Zhang L,Zhang L,Calderone R

更新日期：2013-01-01 00:00:00

abstract：:Retrospective analysis of 189 nonredundant strains of Pseudomonas aeruginosa sequentially recovered from the sputum samples of 46 cystic fibrosis (CF) patients over a 10-year period (1998 to 2007) revealed that 53 out of 189 (28%) samples were hypersusceptible to the beta-lactam antibiotic ticarcillin (MIC < or = 4 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Vettoretti L,Plésiat P,Muller C,El Garch F,Phan G,Attrée I,Ducruix A,Llanes C

更新日期：2009-05-01 00:00:00

abstract：:Six strains of ampicillin-resistant Haemophilus influenzae type b were studied in vitro for synergy between ampicillin and nafcillin. The minimal inhibitory concentrations for these strains with 10(4) colony-forming units per ml were 6.25 to 12.5 microgram of ampicillin per ml and 6.25 to 25 microgram of nafcillin per...

journal_title：Antimicrobial agents and chemotherapy

authors： Yogev R,Burkholder E,Davis AT

更新日期：1980-03-01 00:00:00

abstract：:Macrolides are the antimicrobials of choice for treating human campylobacteriosis. The recent emergence of erm(B) in Campylobacter bacteria threatens the utility of this class of antibiotics. Here we report the constitutive and inducible expression of erm(B) in Campylobacter isolates derived from diarrheal patients an...

journal_title：Antimicrobial agents and chemotherapy

authors： Deng F,Shen J,Zhang M,Wu C,Zhang Q,Wang Y

更新日期：2015-10-01 00:00:00

abstract：:The objectives of this study were to investigate raltegravir transport across several blood-tissue barrier models and the potential interactions with drug efflux transporters. Raltegravir uptake, accumulation, and permeability were evaluated in vitro in (i) P-glycoprotein (P-gp), breast cancer resistance protein (BCRP...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoque MT,Kis O,De Rosa MF,Bendayan R

更新日期：2015-05-01 00:00:00

abstract：:To determine whether rifampin reduces concentrations of trimethoprim (TMP) and sulfamethoxazole (SMX) in serum of human immunodeficiency virus (HIV)-infected persons, levels of these agents were determined by high-performance liquid chromatography before and after more than 12 days of standard antituberculosis treatme...

journal_title：Antimicrobial agents and chemotherapy

authors： Ribera E,Pou L,Fernandez-Sola A,Campos F,Lopez RM,Ocaña I,Ruiz I,Pahissa A

更新日期：2001-11-01 00:00:00

abstract：:Sordarin and its derivatives are antifungal compounds of potential clinical interest. Despite the highly conserved nature of the fungal and mammalian protein synthesis machineries, sordarin is a selective inhibitor of protein synthesis in fungal organisms. In cells sensitive to sordarin, its mode of action is through ...

journal_title：Antimicrobial agents and chemotherapy

authors： Botet J,Rodríguez-Mateos M,Ballesta JP,Revuelta JL,Remacha M

更新日期：2008-05-01 00:00:00

abstract：:The aim of the present study was to assess whether amphotericin B (AmB)-Myrj 59, AmB-polyoxyethyleneglycol 24 cholesterol (PC), and AmB-Synperonic A50 (SA50) were less nephrotoxic than AmB-deoxycholate (DC). Rats were treated with the different AmB formulations (10 mg/kg of body weight) intraperitoneally or with the s...

journal_title：Antimicrobial agents and chemotherapy

authors： Tasset C,Preat V,Bernard A,Roland M

更新日期：1992-07-01 00:00:00

abstract：:We studied the incidence and type of side effects of minocycline in a double-blind study. A total of 45 volunteers (18 men and 27 women) were given minocycline, and 44 volunteers (23 men and 21 women) were given placebo. The men in both the minocycline and placebo groups were significantly (P < 0.0001) larger than the...

journal_title：Antimicrobial agents and chemotherapy

authors： Fanning WL,Gump DW,Sofferman RA

更新日期：1977-04-01 00:00:00

abstract：:Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread. There are currently no proven safe and effective treatment options for RVFV infection. Inhibition of RNA binding to RVFV nucleocapsid protein (N) represents an a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ellenbecker M,Lanchy JM,Lodmell JS

更新日期：2014-12-01 00:00:00

abstract：:Moxifloxacin (BAY12-8039) is a new 8-methoxyquinolone shown to be active against Mycobacterium tuberculosis in vitro. We tested moxifloxacin for activity in mice against M. tuberculosis CSU93, a highly virulent, recently isolated clinical strain. The MIC of moxifloxacin for the CSU93 strain was 0.25 microg/ml. The ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Miyazaki E,Miyazaki M,Chen JM,Chaisson RE,Bishai WR

更新日期：1999-01-01 00:00:00

abstract：:The efficacy and safety of amoxicillin-clavulanic acid were compared with those of co-trimoxazole in the treatment of acute urinary tract infections. A total of 104 patients (mean age, 52 years) with clinical and laboratory evidence of acute urinary tract infection were enrolled in the study. Characteristics and infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Karachalios GN

更新日期：1985-11-01 00:00:00

abstract：:Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae strains have spread worldwide and become a major threat in health care facilities. Transmission of blaKPC, the plasmid-borne KPC gene, can be mediated by clonal spread and horizontal transfer. Here, we report the complete nucleotide sequences of two nov...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen L,Chavda KD,Melano RG,Hong T,Rojtman AD,Jacobs MR,Bonomo RA,Kreiswirth BN

更新日期：2014-01-01 00:00:00

abstract：:The incidence of measles virus (MV) infection has been significantly reduced in many nations through extensive vaccination; however, the virus still causes significant morbidity and mortality in developing countries. Measles outbreaks also occur in some developed countries that have failed to maintain high vaccine cov...

journal_title：Antimicrobial agents and chemotherapy

authors： Plemper RK,Doyle J,Sun A,Prussia A,Cheng LT,Rota PA,Liotta DC,Snyder JP,Compans RW

更新日期：2005-09-01 00:00:00