Abstract:
:The chromosome region 17p13.3 is thought to encode a tumour suppressor gene involved in sporadic breast cancer and other malignancies. Physical ordering of markers has been carried out by a series of multicolour fluorescent in situ hybridisation (FISH) experiments, using isolated yeast artificial chromosomes (YACs) and cosmids. Eight polymorphic markers ordered within this new physical map and one external marker were used to investigate the pattern of loss of heterozygosity in a panel of 40 sporadic breast tumour patients. The data revealed a region of high loss (60%) within distal 17p13.3, defined by markers D17S926, D17S695 and D17S849 which mapped close together. A contig of YACs was constructed physically linking these three markers.
journal_name
Hum Mol Genetjournal_title
Human molecular geneticsauthors
Stack M,Jones D,White G,Liscia DS,Venesio T,Casey G,Crichton D,Varley J,Mitchell E,Heighway Jdoi
10.1093/hmg/4.11.2047subject
Has Abstract,Author List Incompletepub_date
1995-11-01 00:00:00pages
2047-55issue
11eissn
0964-6906issn
1460-2083journal_volume
4pub_type
杂志文章abstract::The fragile X syndrome is characterized at the molecular level by expansion and methylation of a CGG trinucleotide repeat located within the FMR1 locus. The tissues of most full mutation carriers are mosaic for repeat size, but these mutational patterns tend to be well conserved when comparing multiple tissues within ...
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