Abstract:
:Amelogenesis imperfecta (AI), is an inherited odontological disease which affects the formation of enamel. We report a linkage analysis study performed on three Swedish families, where the affected members had an autosomal dominant variant of AI (ADAI) clinically characterized as local hypoplastic. Significant linkage to microsatellite markers on chromosome 4q were obtained. Recombinations localized the ADAI locus to a chromosome region which contains both a locus for the dental disorder dentinogenesis imperfecta and the albumin gene. Serum albumin has been suggested to play a role in enamel formation, and the albumin gene is therefore a candidate gene for this genetic disease.
journal_name
Hum Mol Genetjournal_title
Human molecular geneticsauthors
Forsman K,Lind L,Bäckman B,Westermark E,Holmgren Gdoi
10.1093/hmg/3.9.1621subject
Has Abstractpub_date
1994-09-01 00:00:00pages
1621-5issue
9eissn
0964-6906issn
1460-2083journal_volume
3pub_type
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