Peripheral nerve regeneration in the apolipoprotein-E-deficient mouse.

Abstract:

:Apolipoprotein E (apo E) is thought to mediate the reutilization of myelin cholesterol for nerve regeneration. Prior research suggests that apo E is not essential for nerve regeneration following a nerve crush injury. This study was conducted to determine if apo E is essential for nerve regeneration after nerve transection and interposition nerve autograft. Nerve regeneration of transgenic apo E-deficient mice was compared with control mice after a sciatic nerve neurolysis and repair and interposition autograft. Histomorphometric assessment and histology were performed on distal nerve segments to evaluate nerve regeneration. Apo E-deficient mice demonstrated no difference in total fiber number or nerve fiber width when compared with controls; however, the nerve fiber density and percent neural tissue of apo E-deficient mice were significantly less than controls following nerve repair. Apo E deficiency does not affect nerve regeneration. It is likely that the low nerve fiber density and the low percent neural tissue associated with apo E-deficiency result from impairment in the disposal of myelin debris.

journal_name

J Reconstr Microsurg

authors

Genden EM,Watanabe O,Mackinnon SE,Hunter DA,Strasberg SR

doi

10.1055/s-2002-33321

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

495-502

issue

6

eissn

0743-684X

issn

1098-8947

journal_volume

18

pub_type

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