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Evaluation of dopexamine hydrochloride as a renoprotective agent during aortic surgery.

Abstract：

:Thirty-two patients undergoing elective infrarenal aortic surgery were randomly assigned to receive a perioperative infusion of either dopexamine hydrochloride at a rate of 2 micrograms/kg/min (n = 15) or 0.9% saline solution as placebo (n = 17). Renal function was monitored by regular measurements of serum creatinine levels. There were significant mean percentage increases in serum creatinine (p < 0.001) at all time points up to 3 days postoperatively in the placebo group but only at 2 and 12 hours in the dopexamine group. It was concluded that dopexamine hydrochloride confers renal protection in patients undergoing aortic reconstruction.

journal_name

Ann Vasc Surg

journal_title

Annals of vascular surgery

authors

Welch M,Newstead CG,Smyth JV,Dodd PD,Walker MG

doi

10.1007/BF02143865

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

488-92

issue

5

eissn

0890-5096

issn

1615-5947

pii

S0890-5096(06)62083-9

journal_volume

9

pub_type

临床试验,杂志文章,随机对照试验

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