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Reversal of Lower-Extremity Intermittent Claudication and Rest Pain by Hydration.

Abstract：

BACKGROUND:Medical treatment of disabling intermittent claudication or critical limb-threatening ischemia causing rest pain often fails or has partial response. METHODS:In this pilot study, 36 patients (12 females) affected by disabling intermittent claudication or rest pain of the lower extremities were exposed to a daily 3-L water intake for up to 6 weeks. Cutaneous foot temperature, ankle/brachial index, time and distance of claudication, and pain intensity were recorded before and at the completion of the hydration period. RESULTS:Patients with a mean ± SE age of 71 ± 2 years (range, 40-86) had disabling claudication (less than 100 meters) for more than 5 months while 11% reported pain at rest. A 6-week water intake of more than 2,500 mL/24 hr was achieved in 35 of the 36 patients enrolled in the study. Increased water intake was associated with significant improvements in median ankle/brachial index (from 0.60 to 0.76; P < 0.0001) and skin temperature (first dorsal right toe, from 29.95°C to 30.0°C, P < 0.001). Time and distance to report claudication of supervised treadmill exercise improved from 1.25 to 6.25 min (P < 0.0001) and from 100 meters to 535 meters (P < 0.0001), respectively. CONCLUSIONS:This study suggests that hydration attained by daily water consumption of more than 2.5 L has a robust impact on reducing the symptoms of disabling claudication and rest pain caused by peripheral vascular disease.

journal_name

Ann Vasc Surg

journal_title

Annals of vascular surgery

authors

Fernández S,Parodi JC,Moscovich F,Pulmari C

doi

10.1016/j.avsg.2018.01.074

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

1-7

eissn

0890-5096

issn

1615-5947

pii

S0890-5096(18)30148-1

journal_volume

49

pub_type

杂志文章,多中心研究

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