Abstract:
OBJECTIVES:We prospectively evaluated the mechanism of syncope in patients with positive adenosine triphosphate (ATP) tests (defined as the induction of atrioventricular [AV] block with a ventricular pause >/=6 s after an intravenous bolus of 20 mg ATP). BACKGROUND:Patients with unexplained syncope tend to have more positive ATP tests results than those without syncope. METHODS:An implantable loop recorder (ILR) was inserted in 36 ATP-positive patients (69 +/- 10 years; 22 women; median of 6 syncopal episodes); 15 of them also had a positive response to tilt testing. RESULTS:During the follow-up of 18 +/- 9 months, 18 patients (50%) had syncopal recurrence and 16 (44%) had an electrocardiographically documented episode: AV block (n = 3: paroxysmal in 2 and permanent in 1), AV block followed by sinus arrest (n = 1), sinus arrest (n = 5), sinus bradycardia <40 beats/min (n = 2), normal sinus rhythm (n = 2), sinus tachycardia (n = 1), rapid atrial fibrillation (n = 1), and ectopic atrial tachycardia (n = 1). Bradycardia was documented in a total of 11 cases (69%), and a long ventricular pause (4 to 29 s) was present in eight cases (50%). All three patients with ILR-documented AV block had previously had a negative tilt test, whereas seven of eight with ILR-documented sinus bradycardia or sinus arrest had previously had a positive tilt test. CONCLUSIONS:In patients with adenosine-sensitive syncope, the mechanism of syncope is heterogeneous, although bradycardia is the most frequent finding. Adenosine triphosphate-induced AV block predicts AV block as the mechanism of spontaneous syncope in only a few tilt-negative patients.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Donateo P,Brignole M,Menozzi C,Bottoni N,Alboni P,Dinelli M,Del Rosso A,Croci F,Oddone D,Solano A,Puggioni Edoi
10.1016/s0735-1097(02)02621-9subject
Has Abstractpub_date
2003-01-01 00:00:00pages
93-8issue
1eissn
0735-1097issn
1558-3597pii
S0735109702026219journal_volume
41pub_type
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