Angiotensin II effects in a swine model of cardiac arrest.

Abstract:

STUDY OBJECTIVE:To evaluate the effect of different doses of the vasopressor angiotensin II on aortic diastolic and coronary perfusion pressures in a swine model of cardiac arrest. DESIGN:Immature swine were anesthetized and hemodynamically monitored. Ventricular fibrillation was induced; CPR was begun after ten minutes of ventricular fibrillation. Aortic and right atrial pressures were recorded continuously throughout the experiment. SETTING:Animal research laboratory. PARTICIPANTS:Immature swine weighing 21 to 32 kg. INTERVENTIONS:Angiotensin II was administered in doses of 25, 50, 75, and 100 micrograms/kg at 13 minutes of ventricular fibrillation. Each dose was tested in four swine. RESULTS:Except for animals receiving 25 micrograms/kg, aortic diastolic pressure increased significantly in all groups after administration of angiotensin II compared with groups receiving CPR alone. Coronary perfusion pressure increased significantly only with 50- and 75-micrograms/kg doses. There were no significant differences in hemodynamic parameters among the different dose groups. CONCLUSION:Angiotensin II in doses of 50, 75, and 100 micrograms/kg significantly increased aortic diastolic pressure, and doses of 50 and 75 micrograms/kg significantly increased coronary perfusion pressure in this model of cardiac arrest.

journal_name

Ann Emerg Med

authors

Little CM,Hobson JL,Brown CG

doi

10.1016/s0196-0644(05)80213-6

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

244-7

issue

2

eissn

0196-0644

issn

1097-6760

pii

S0196-0644(05)80213-6

journal_volume

22

pub_type

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