Abstract:
:This study compared different concentrations of transforming growth factor-beta 1 (TGF-beta1) used for short-term preincubation in vitro of large periosteal explants to determine the effect of chondrogenesis and the fate of repair cartilage over time. Eighty-two rabbits were divided into four groups: group A, non-grafted; group B, non-incubated grafted; group C, 100 ng/mL recombinant human (rh) TGF-beta1 preincubated grafted; and group D, 20 ng/mL rhTGF-beta1 preincubated grafted. Rabbits from each group were sacrificed at intervals between 2 and 24 weeks. Histologic slides were stained with safranin O and were scored based on a subjective scoring system. Group A healed with non-cartilaginous material. Group B healed with hyaline cartilage-like material with progressive thinning of this regenerated layer; at 24 weeks, this layer was fibrous tissue. Group C enhanced repair with hyaline cartilage-like material but accelerated early degeneration and osteophyte formation; the cartilage became fibrous tissue at 24 weeks. Group D did not enhance cartilaginous repair. At 24 weeks, all groups had the same result. The 100 ng/mL rhTGF-beta1 preincubation in vitro with periosteum enhanced early osteochondral repair but did not show prolonged durability. Clinical application of this growth factor necessitates further study.
journal_name
Orthopedicsjournal_title
Orthopedicsauthors
Hsieh PC,Thanapipatsiri S,Anderson PC,Wang GJ,Balian Gsubject
Has Abstractpub_date
2003-04-01 00:00:00pages
393-402issue
4eissn
0147-7447issn
1938-2367journal_volume
26pub_type
杂志文章相关文献
ORTHOPEDICS文献大全abstract::A combination of external and internal fixation techniques for a fibular lengthening procedure using the Ilizarov method is described. The technique is minimally invasive, allows precise deformity correction, enables early weight bearing, and minimizes the time that the patient wears the external fixator. ...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract::Compartmental syndrome of the forearm is a well-recognized complication of upper extremity injuries. An unusual case of the syndrome is presented, which developed after a "sprained" wrist. The etiology of the syndrome in this case was possibly tearing of anterior compartment muscle fibers when the wrist was forcibly e...
journal_title:Orthopedics
pub_type: 社论
doi:10.3928/0147-7447-19840201-17
更新日期:1984-02-01 00:00:00
abstract::Displaced femoral neck fractures in physiologically young patients are best treated with anatomic reduction and stable fixation. Several surgical approaches to the femoral neck have previously been described, although they are fraught with disadvantages such as poor visualization, the need for 2 incisions, and risk of...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20150701-03
更新日期:2015-07-01 00:00:00
abstract::Concerns exist regarding using short stems during total hip arthroplasties performed in elderly patients. For this study, the authors assessed sequential bone remodeling findings in metaphyseal-loading short stems using serial radiography. A total of 100 consecutive primary THAs using short stems were performed in pat...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20140626-57
更新日期:2014-07-01 00:00:00
abstract::Various fixation techniques have been described for ruptured distal biceps tendons. The authors hypothesized that no significant differences would be found between the mean failure strength, maximum strength, and stiffness of the interference screw and hybrid technique. Fourteen fresh-frozen human cadaveric elbows wer...
journal_title:Orthopedics
pub_type: 杂志文章,随机对照试验
doi:10.3928/01477447-20131021-17
更新日期:2013-11-01 00:00:00
abstract::There are approximately 25 million amateur golfers in the United States, making up almost 10% of the entire US population. The purpose of this study was to evaluate short-term outcomes and rates of return to sport among recreational golfers who underwent hip arthroscopy for the treatment of labral tears. Data were pro...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20180524-02
更新日期:2018-07-01 00:00:00
abstract::The purpose of this study was to assess (1) the prevalence of the fracture of ceramic heads implanted on used trunnions of well-fixed stems without using a titanium adapter sleeve; (2) the prevalence of trunnionosis secondary to fretting and/or corrosion at the trunnion of the well-fixed stem; and (3) clinical and rad...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20180501-03
更新日期:2018-05-01 00:00:00
abstract::Twenty-one quadricepsplasty procedures were carried out on 21 patients over a 14-year period due to posttraumatic stiffness of the knee joint. Three patients (14.2%) required mobilization under anesthesia in the early postoperative period. The average interval between injury and quadricepsplasty was 18 months (range: ...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract::Laminar closure is associated with expansive open-door laminoplasty. Suture anchor fixation and titanium miniplate fixation are used to prevent laminar reclosure. However, few studies have compared the clinical effects of the 2 fixation methods. The authors performed a prospective study of 55 patients with cervical sp...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20131219-20
更新日期:2014-01-01 00:00:00
abstract::Degenerative changes of the lumbar spine may occur in either the anterior or posterior intervertebral articulations. Computed tomography is an ideal modality in evaluating these processes because of its optimal plane of section and its ability to image both osseous and soft tissue structures. ...
journal_title:Orthopedics
pub_type: 社论
doi:10.3928/0147-7447-19810201-13
更新日期:1981-02-01 00:00:00
abstract::Heterotopic ossification and scapular notching are common following reverse total shoulder arthroplasty. Compared with the original Grammont-style prosthesis with a medialized center of rotation (COR) and a 155° neck-shaft angle, lateralization of COR and reduction of neck-shaft angle have been associated with decreas...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20180613-01
更新日期:2018-07-01 00:00:00
abstract::Posterior short-segment instrumentation for thoracolumbar burst fracture is known for a high implant failure rate because of the lack of anterior support. Anterior body augmentation by transpedicular bone grafting has been developed as an alternative to overcome this failure. However, the efficacy of transpedicular bo...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20090527-11
更新日期:2009-07-01 00:00:00
abstract::The effect of recombinant human erythropoietin on autologous blood donation was investigated in 73 rheumatoid arthritis patients who underwent hip or knee arthroplasty. Autologous blood donation of 400 mL was successful with recombinant human erythropoietin (12,000 U per week), and no homologous blood was required. Th...
journal_title:Orthopedics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2001-01-01 00:00:00
abstract::Hemiarthroplasty (HA) of the shoulder has several potential advantages over total shoulder arthroplasty (TSA), particularly in the elderly population. This study reviewed long-term results of HA and TSA in patients older than 70 years with glenohumeral osteoarthritis. During a 30-year period, 403 shoulders had undergo...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20180621-03
更新日期:2018-07-01 00:00:00
abstract::Mixing implants with differing metallic compositions has been avoided for fear of galvanic corrosion and subsequent failure of the implants and of bone healing. The purpose of this study was to evaluate upper-extremity fractures treated with open reduction and internal fixation with metallic implants that differed in ...
journal_title:Orthopedics
pub_type: 杂志文章,多中心研究
doi:10.3928/01477447-20130821-21
更新日期:2013-09-01 00:00:00
abstract::The activity of eight antimicrobial agents which might be used in the treatment of staphylococcal osteomyelitis was tested under anaerobic conditions similar to those found in chronically infected bone. An agar-dilution method was employed to determine the minimum inhibitory concentrations of tobramycin, vancomycin, t...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract::There are two main problems with muscle tendon lengthening: thinness created by the technical procedure weakens the tendon, and in short tendons, lengthening may not provide enough length for the amount of joint motion required. In proximal rectus femoris lengthening, the distal ends of the reflected and straight head...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
abstract::From February 1978 to March 1981, 13 English-McNab cementless, semiconstrained, implant shoulder arthroplasties were performed in 12 people. The ages of the patients at the time of surgery ranged from 53 to 73 years with an average of 62 years. The preoperative diagnoses were rheumatoid arthritis, primary osteoarthros...
journal_title:Orthopedics
pub_type: 社论
doi:10.3928/0147-7447-19830401-04
更新日期:1983-04-01 00:00:00
abstract::This study assesses femoral neck shortening and its effect on gait pattern and muscle strength in patients with femoral neck fractures treated with internal fixation. Seventy-six patients from a multicenter randomized controlled trial participated. Patient characteristics and Short Form 12 and Western Ontario and McMa...
journal_title:Orthopedics
pub_type: 杂志文章,随机对照试验
doi:10.3928/01477447-20130624-13
更新日期:2013-07-01 00:00:00
abstract::The purpose of this study was to compare the results of anterior approach vs posterior approach in the treatment of chronic thoracolumbar fractures. A total of 36 patients with chronic thoracolumbar fractures were divided into 2 groups. Group A was treated by an anterior approach and group B was treated by a posterior...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20120123-05
更新日期:2012-02-17 00:00:00
abstract::The metacarpophalangeal (MP) joint is resistant to injury due to its strong capsuloligamentous structures, which include the volar plate and deep transverse metacarpal and collateral ligaments. Complex MP joint dislocations are, by definition, irreducible by closed means and require open reduction, as the volar plate ...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20081101-22
更新日期:2008-11-01 00:00:00
abstract::Lesions of knee's lateral side are less common than medial injuries. The anatomy of the lateral ligaments and the presence of additional structures (eg, fibula head) can cause diagnostic problems. Isolated dislocation of the proximal tibiofibular joint is unusual; therefore, it may be overlooked in the emergency depar...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:2008-06-01 00:00:00
abstract::The purposes of the current investigation are to evaluate the epidemiology of water sport injuries at a coastal tertiary trauma center and to determine the association of these activities with spinal column injury and to determine whether aquatic trauma injuries differ significantly from those that occur terrestrially...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20150902-60
更新日期:2015-09-01 00:00:00
abstract::Mobile image intensifiers are more readily used to assess acetabular cup placement when performing a total hip arthroplasty through a direct anterior approach. However, patient positioning affects pelvic tilt and rotation, which in turn requires proper C-arm fluoroscopy adjustments for image interpretation. The author...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20130920-06
更新日期:2013-10-01 00:00:00
abstract::This is a 1.2- to 5.3-year survival and clinicoradiologic study of patients with the Birmingham Mid-Head Resection (BMHR) device (Smith & Nephew Orthopaedics, Warwick, United Kingdom). Sixty consecutive hips implanted with this device between 2003 and 2007 were reviewed with hip outcome questionnaires, clinical examin...
journal_title:Orthopedics
pub_type: 临床试验,杂志文章
doi:
更新日期:2008-12-01 00:00:00
abstract::Distal biceps tendon ruptures are rare injuries that usually occur in middle-aged men. Most of these injuries are repaired acutely to restore preinjury function and strength. There is concern regarding the higher prevalence of certain complications with the double-incision technique. As such, the single-incision techn...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20170615-03
更新日期:2017-07-01 00:00:00
abstract::Reconstruction of the femur depends on the quantity of bone loss and the quality of the remaining bone stock. Multiple classifications and reporting systems can be used to characterize the bone defect. We present a simple algorithmic approach for proximal femoral bone loss reconstruction during revision total hip arth...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20090728-18
更新日期:2009-09-01 00:00:00
abstract::Previous studies have reported thermal injuries with thick cast materials and warm dip water temperatures, often much higher than is clinically applicable. The goal of this study was to assess the temperature produced in vivo by current casting techniques and materials. The study was done using clinically applicable m...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20101221-11
更新日期:2011-01-01 00:00:00
abstract::Cigarette smokers experience greater rates of morbidity and mortality. Despite the known health risks, use of tobacco products remains high throughout the United States (approximately 19.3% of adults). Tobacco use is associated with higher rates of cardiovascular illness, cardiovascular risk factors (ie, hypertension ...
journal_title:Orthopedics
pub_type: 杂志文章
doi:10.3928/01477447-20120525-07
更新日期:2012-06-01 00:00:00
abstract::Six iliac crest bone biopsies were obtained from five patients with renal osteodystrophy and osteosclerotic lesions to investigate the mechanism of osteosclerosis in renal osteodystrophy. Each specimen was prepared in an undecalcified fashion and measured under light microscopy for routine analysis and histomorphometr...
journal_title:Orthopedics
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00