Abstract:
:Developing and validating quantitative cationic-activity relationships or (Q)CARs to predict the toxicity metals is challenging because of issues associated with metal speciation, complexation and interactions within biological systems and the media used to study these interactions. However, a number of simplifying assumptions can be used to develop and validate (Q)CARs to predict the toxicity of metals: The ionic form is the most active form of a metal; the bioactivity of a dissolved metal is correlated with its free ion concentration or activity; most metals exist in biological systems as cations, and differences in metal toxicity result from differences in metal ion binding to biological molecules (ligand-binding). In summary, it appears that certain useful correlations can be made between several physical and chemical properties of ions (mostly cations) and toxicity of metals. This review provides a historical perspective of studies that have reported correlations between physical and chemical properties of cations and toxicity to mammalian and nonmammalian species using in vitro and in vivo assays. To prepare this review, approximately 100 contributions dating from 1839 to 2003 were evaluated and the relationships between about 20 physical and chemical properties of cations and their potential to produce toxic effects were examined.
journal_name
Environ Toxicol Chemjournal_title
Environmental toxicology and chemistryauthors
Walker JD,Enache M,Dearden JCdoi
10.1897/02-568subject
Has Abstractpub_date
2003-08-01 00:00:00pages
1916-35issue
8eissn
0730-7268issn
1552-8618journal_volume
22pub_type
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