Abstract:
:We recently reported that different purification methods of recombinant adeno-associated virus type 2 (rAAV2) affect the transduction characteristics following subretinal injection. In this study, we examined the roles of contaminant proteins from the HEK-293 cells and helper adenovirus, inactivation of helper adenovirus and cell stress induced by DNA-damaging agents in rAAV-mediated retinal transduction. Our results showed that contaminating factors/proteins resulting from the helper E1 deleted adenovirus are possibly responsible for efficient RPE transduction. Future studies of these factors will undoubtedly lead to development of new therapeutic approaches to PR- and RPE-specific retinal diseases.
journal_name
Vision Resjournal_title
Vision researchauthors
Shen WY,Lai YK,Lai CM,Rakoczy PEdoi
10.1016/j.visres.2003.09.032subject
Has Abstractpub_date
2004-02-01 00:00:00pages
339-48issue
4eissn
0042-6989issn
1878-5646pii
S0042698903006254journal_volume
44pub_type
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