Differential modulation of brain benzodiazepine receptor subtypes by ricinelaidic acid in vitro.

abstract：:The chiral inversion properties of 4-(4-methylphenyl)-2-methylthiomethyl-4-oxobutanoic acid (KE-748), an active metabolite of 2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (KE-298), were compared with those of ibuprofen in rats. After administration of R(-)-[2 alpha-2H]KE-748, S(+)-KE-748 was present in the...

journal_title：Biochemical pharmacology

authors： Yoshida H,Kohno Y,Endo H,Yamaguchi J,Fukushima K,Suwa T,Hayashi M

更新日期：1997-01-24 00:00:00

abstract：:4-S-Cysteaminylphenol (4-S-CAP) and the corresponding catechol 4-S-cysteaminylcatechol (4-S-CAC) have been evaluated for melanocytotoxicity. It was shown recently that tyrosinase oxidation of these substrates produces a violet pigment, dihydro-1,4-benzothiazine-6,7-dione (BQ). In this study we examined whether BQ is t...

journal_title：Biochemical pharmacology

authors： Hasegawa K,Ito S,Inoue S,Wakamatsu K,Ozeki H,Ishiguro I

更新日期：1997-05-15 00:00:00

abstract：:Somatostatin receptors from rabbit retinal membranes were solubilized in an active form using a mixture of the detergent n-octyl b-D-glucopyranoside (OG) and CHAPS. The binding of [125I]-Try11-somatostatin to the soluble extract was saturable and of high affinity, with an apparent affinity constant (Kd) of 0.60 +/- 0....

journal_title：Biochemical pharmacology

authors： Liapakis G,Politou E,Thermos K

更新日期：1993-05-05 00:00:00

abstract：:The amino acid conjugation of the phenoxyherbicides 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T) by animals was examined at the level of the enzymes catalyzing the reactions. The phenoxyherbicides were not substrates for the bile acid conjugating system but were substrates for the mit...

journal_title：Biochemical pharmacology

authors： Kelley M,Vessey DA

更新日期：1986-01-15 00:00:00

abstract：:β1-Adrenergic receptor (β1-AR) agonists and antagonists are widely used in the treatment of major cardiovascular diseases such as heart failure and hypertension. The β1-AR like other G protein-coupled receptors (GPCRs) are endocytosed in response to intense agonist activation. Recycling of the agonist-internalized β1-...

journal_title：Biochemical pharmacology

authors： Nooh MM,Mancarella S,Bahouth SW

更新日期：2016-11-15 00:00:00

abstract：:We have investigated a series of novel 4-aminoquinoline analogues related to amodiaquine, that possess side chain modifications designed to influence both drug pKa and lipophilicity. These compounds have been used to determine the influence of physicochemical properties on antimalarial activity against, and accumulati...

journal_title：Biochemical pharmacology

authors： Hawley SR,Bray PG,O'Neill PM,Park BK,Ward SA

更新日期：1996-09-13 00:00:00

abstract：:Carvedilol, a non-selective beta-adrenoreceptor blocker, has been shown to possess a high degree of cardioprotection in experimental models of myocardial damage. Reactive oxygen species have been proposed to be implicated in such situations, and antioxidants have been demonstrated to provide partial protection to the ...

journal_title：Biochemical pharmacology

authors： Santos DJ,Moreno AJ

更新日期：2001-01-15 00:00:00

abstract：:In order to clarify the mechanism of substance P (SP)-induced cortisol secretion from bovine adrenocortical (BAC) cells, protein synthesis at the early stage of SP-stimulation in BAC cells was investigated. Both SP and adrenocorticotropic hormone (ACTH) increased [3H]leucine uptake into BAC cells in a dose-dependent f...

journal_title：Biochemical pharmacology

authors： Yoshida T,Mio M,Tasaka K

更新日期：1992-10-06 00:00:00

abstract：:Human red blood cells and male Sprague-Dawley rats were treated in vitro and in vivo, respectively, with phenylhydrazine in order to determine whether the release of volatile hydrocarbons can serve as a suitable index for phenylhydrazine-induced red blood cell peroxidation. Lipid peroxidation following phenylhydrazine...

journal_title：Biochemical pharmacology

authors： Clemens MR,Remmer H,Waller HD

更新日期：1984-06-01 00:00:00

abstract：:The use of either methadone or buprenorphine for treatment of the pregnant opiate-dependent patient improves maternal and neonatal outcome. However, patient outcomes are often complicated by neonatal abstinence syndrome (NAS). The incidence and severity of NAS should depend on opiate concentration in the fetal circula...

journal_title：Biochemical pharmacology

authors： Hemauer SJ,Patrikeeva SL,Nanovskaya TN,Hankins GD,Ahmed MS

更新日期：2009-11-01 00:00:00

abstract：:Diabetic retinopathy (DR) is a secondary complication of diabetes. DR can cause irreversible blindness, and its pathogenesis is considered multifactorial. DR can progress from non-proliferative DR to proliferative DR, characterized by retinal neovascularization. The main cause of vision loss in diabetic patients is di...

journal_title：Biochemical pharmacology

authors： Lazzara F,Fidilio A,Platania CBM,Giurdanella G,Salomone S,Leggio GM,Tarallo V,Cicatiello V,De Falco S,Eandi CM,Drago F,Bucolo C

更新日期：2019-10-01 00:00:00

abstract：:Ischemia/reperfusion (I/R) injury constitutes a major reason for failure of liver surgeries and transplantation. I/R injury is more severe in steatotic livers and limits their use in transplantation. Here, we present a novel and selective Toll-like receptor 9 (TLR9) antagonist COV08-0064 and test its potential to prot...

journal_title：Biochemical pharmacology

authors： Shaker ME,Trawick BN,Mehal WZ

更新日期：2016-07-15 00:00:00

abstract：:Epidemiological study has shown strong correlation between the Helicobacter pylori (H. pylori) infection and gastric carcinogenesis. However, the mechanism by which H. pylori induces gastric carcinogenesis is not known. In this review, we focused on the product of cytotoxin-associated gene A (CagA), one of the importa...

journal_title：Biochemical pharmacology

authors： Handa O,Naito Y,Yoshikawa T

更新日期：2007-06-01 00:00:00

abstract：:Azithromycin is considered an effective drug to treat the perinatal mycoplasma infection. However, there is a lack of studies on developmental toxicity of azithromycin. In this study, we observed the developmental toxicity of fetal liver induced by prenatal azithromycin exposure (PAE) in mice and explored the potentia...

journal_title：Biochemical pharmacology

authors： Liu K,Wang G,Li L,Chen G,Gong X,Zhang Q,Wang H

更新日期：2020-10-01 00:00:00

abstract：:HOE 731, a substituted thienoimidazole derivative, was studied on [14C] aminopyrine uptake and oxygen consumption in isolated rabbit gastric glands. HOE 731 caused a concentration-dependent inhibition of [14C]aminopyrine uptake during histamine and dbcAMP stimulation. The inhibition during dbcAMP stimulation was in ac...

journal_title：Biochemical pharmacology

authors： Herling AW,Becht M,Lang HJ,Scheunemann KH,Weidmann K,Scholl T,Rippel R

更新日期：1990-10-15 00:00:00

abstract：:The participation of mitochondria in the mechanism of tumor cell death induced by non-steroid anti-inflammatory drugs is uncertain. Here we show that ibuprofen induces death of Walker 256 tumor cells independently on mitochondrial depolarization as estimated by flow cytometry using DioC(6)(3). Oligomycin increased mit...

journal_title：Biochemical pharmacology

authors： Campos CB,Degasperi GR,Pacífico DS,Alberici LC,Carreira RS,Guimarães F,Castilho RF,Vercesi AE

更新日期：2004-12-01 00:00:00

abstract：:Thrombospondin (TSP)-2, a matricellular glycoprotein of the TSP family, regulates multiple biological functions, including proliferation, angiogenesis, cell adhesion, and extracellular matrix (ECM) modeling. The clinical relevance of TSP-2 has been explored in many different cancers. TSP-2 expression levels vary betwe...

journal_title：Biochemical pharmacology

authors： Liu JF,Lee CW,Tsai MH,Tang CH,Chen PC,Lin LW,Lin CY,Lu CH,Lin YF,Yang SH,Chao CC

更新日期：2018-09-01 00:00:00

abstract：:Phospholipase A2 (PLA2) cleave phospholipids preferentially at the sn-2 position, liberating free fatty acids and lysophospholipids. They are classified into six main groups based on size, location, function, substrate specificity and calcium requirement. These classes include secretory PLA2 (sPLA2), cytosolic (cPLA2)...

journal_title：Biochemical pharmacology

authors： Quach ND,Arnold RD,Cummings BS

更新日期：2014-08-15 00:00:00

abstract：:Oleanolic acid (OA) is a natural triperpenoid that protects against a variety of hepatotoxicants such as carbon tetrachloride, cadmium, acetaminophen, and bromobenzene. To gain insight into the molecular mechanisms of this generalized hepatoprotection, genomic analysis was performed on mouse and rat livers after OA tr...

journal_title：Biochemical pharmacology

authors： Liu J,Wu Q,Lu YF,Pi J

更新日期：2008-10-01 00:00:00

abstract：:The effect of oxygen concentration and Ca2+ omission on CCl4-induced hepatotoxicity was studied in a non-recirculating and hemoglobin-free liver perfusion system using phenobarbital-pretreated rats. With 95% O2-saturated perfusate, infusion of 0.5 mM CCl4 caused an instantaneous increase of thiobarbituric acid reactiv...

journal_title：Biochemical pharmacology

authors： Masuda Y,Nakamura Y

更新日期：1990-10-15 00:00:00

abstract：:The influence of monoamine oxidases A and B on the metabolism of dopamine or the expanded dopamine pool following L-dopa administration remains unclear. This study found that treatment of Sprague-Dawley rats with monoamine oxidase inhibitors strongly affected L-dopa metabolism in the brain, but the influence varied wi...

journal_title：Biochemical pharmacology

authors： Nguyen TB,Angers M

更新日期：1987-05-15 00:00:00

abstract：:The disturbances of the cholesterol synthesis and metabolism described in Alzheimer's disease (AD) may be both a consequence of the neurodegenerative process and a contributor to the pathogenesis. These putative relationships and their underlying mechanisms are not well understood. The aim of this study was to evaluat...

journal_title：Biochemical pharmacology

authors： Popp J,Meichsner S,Kölsch H,Lewczuk P,Maier W,Kornhuber J,Jessen F,Lütjohann D

更新日期：2013-07-01 00:00:00

abstract：:Monocrotaline is a pyrrolizidine alkaloid obtained from the seeds of Crotalaria spectabilis. When perfused through an isolated liver, monocrotaline is metabolized to Ehrlich reactive (E+) metabolites. Metabolism of monocrotaline was faster in livers from male rats than female rats, was inducible with phenobarbital pre...

journal_title：Biochemical pharmacology

authors： Lafranconi WM,Huxtable RJ

更新日期：1984-08-01 00:00:00

abstract：:The role of Ca2+ and protein kinase C (PKC) activity in the release of immunoreactive endothelin-1 (ET-1) from cultured porcine aortic endothelial cells of first or second passage has been studied. ET-1 accumulation within cells and secretion into cell-conditioned medium over 3 and/or 5 hr was measured. Confluent cell...

journal_title：Biochemical pharmacology

authors： Brunner F

更新日期：1995-06-16 00:00:00

abstract：:The activator protein-1 (AP-1) family of transcription factors, including the most common member c-Jun-c-Fos, participates in regulation of expression of numerous genes involved in proliferation, apoptosis, and tumorigenesis in response to a wide array of stimuli including pro-inflammatory cytokines, growth factors, s...

journal_title：Biochemical pharmacology

authors： Weber WM,Hunsaker LA,Gonzales AM,Heynekamp JJ,Orlando RA,Deck LM,Vander Jagt DL

更新日期：2006-10-16 00:00:00

abstract：:Pioglitazone (PIO), a PPARγ agonist that improves glycemic control in type 2 diabetes through its insulin-sensitizing action, has been shown to exhibit beneficial effects in the vessel wall. For instance, it inhibits vascular smooth muscle cell (VSMC) proliferation, a major event in atherosclerosis and restenosis afte...

journal_title：Biochemical pharmacology

authors： Osman I,Segar L

更新日期：2016-02-01 00:00:00

abstract：:Recent studies in our laboratory have revealed that Mn2+ is capable of promoting cell spreading and neurite outgrowth in PC12 cells, a process which is dependent on Mn2+ stimulation of the interaction between extracellular matrix (ECM) components and their corresponding integrin receptors. Since the major ECM proteins...

journal_title：Biochemical pharmacology

authors： Lin WH,Marcucci K,Roth JA

更新日期：1994-04-29 00:00:00

abstract：:Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN) is the most important mediating mechanism. This mechanism involves direct action of inflammatory mediators such as prostaglandins and sympathetic amines. Pharmacologic control of inflammatory pain is based on two principal str...

journal_title：Biochemical pharmacology

authors： Gomes FIF,Cunha FQ,Cunha TM

更新日期：2020-06-01 00:00:00

abstract：:Glucocorticoids (GCs) are steroid hormones widely used as coadjuvants in the treatment of solid tumors due to their anti-inflammatory effects. However, evidence show that they also may induce chemotherapy resistance, probably through their capacity to inhibit apoptosis triggered by antineoplastic drugs. GCs exert thei...

journal_title：Biochemical pharmacology

authors： Orqueda AJ,Dansey MV,Español A,Veleiro AS,Bal de Kier Joffé E,Sales ME,Burton G,Pecci A

更新日期：2014-06-15 00:00:00

abstract：:Double-labelled [methyl-14C,5-3H]CDPcholine has been synthesized and subjected to a pharmacokinetic analysis in several biological systems. In transport experiments with intact human erythrocytes no incorporation of radioactivity is observable. On the other hand the results obtained with perfused rat liver suggest a r...

journal_title：Biochemical pharmacology

authors： Galletti P,De Rosa M,Nappi MA,Pontoni G,del Piano L,Salluzzo A,Zappia V

更新日期：1985-12-01 00:00:00