Neuropeptide Y levels during ischemia and reperfusion in the canine infrarenal aortic revascularization model.

Abstract:

:Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel dog after infrarenal aortic cross-clamping. We found a two- to threefold increase in NPY levels during ischemia (initial 10.0 +/- 1.8 pmol/L vs. maximum 24.7 +/- 2.31 pmole/L, p < 0.001). The increase in NPY remained following reperfusion (initial 10.0 +/- 0.8 pmole/L vs. maximum 23.9 +/- 2.31 pmole/L, p < 0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping.

journal_name

Ann Vasc Surg

authors

Edwards JD,Dovgan PS,Rowley JM,Thorpe PE,Adrian TE,Agrawal DK

doi

10.1007/BF02132996

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

350-5

issue

4

eissn

0890-5096

issn

1615-5947

pii

S0890-5096(06)60358-0

journal_volume

8

pub_type

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