Abstract：
:Tezosentan is a novel dual endothelin receptor antagonist. The purpose of this study was to examine the effect of tezosentan on lung injury induced by abdominal aortic ischemia-reperfusion (IR) in rats. Thirty-two Wistar-albino rats were randomized into four groups (eight per group) as follows: control group (sham laparotomy), aortic IR group (120 min ischemia and 120 min reperfusion), aortic IR + tezosentan group (a bolus intravenous injection of 10 mg/kg tezosentan before ischemia plus continuous intravenous infusion of 1 mg/kg/hr tezosentan during 120 min ischemia and 120 min reperfusion), and control + tezosentan. Blood and lung tissue samples were obtained for biochemical analysis. Protein concentrations in bronchoalveolar lavage fluid and lung wet/dry weight ratios were measured. A histological evaluation was also done. Aortic IR significantly increased (p < 0.05 vs. control group) and tezosentan significantly decreased (p < 0.05 vs. aortic IR group) the plasma level of tumor necrosis factor-alpha; lung tissue levels of malondialdehyde, catalase, and myleperoxidase; and protein concentration in bronchoalveolar lavage fluid and lung wet/dry weight ratio. Histological evaluation showed that tezosentan attenuated the morphological changes associated with lung injury. The results of this study indicate that tezosentan attenuates lung injury induced by aortic IR in rats. We propose that this protective effect of tezosentan is due to (1) reduced systemic inflammatory response, (2) reduced oxidative stress and lipid peroxidation in lung tissue, (3) reduced pulmonary microvascular leakage, and (4) inhibition of leukocyte infiltration into lung tissue.
journal_name
Ann Vasc Surgjournal_title
Annals of vascular surgeryauthors
Kiriş I,Narin C,Gülmen S,Yilmaz N,Sütçü R,Kapucuoğlu Ndoi
10.1016/j.avsg.2008.10.003subject
Has Abstractpub_date
2009-05-01 00:00:00pages
382-91issue
3eissn
0890-5096issn
1615-5947pii
S0890-5096(08)00370-1journal_volume
23pub_type
杂志文章abstract：OBJECTIVES:The objective of this study was to investigate the clinical characteristics of hemodialysis patients with peripheral artery disease (PAD) and the outcomes after endovascular therapy (EVT) in such patients stratified by the primary kidney disease. METHODS:This retrospective observational study evaluated 142 ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2020.11.046
更新日期：2021-01-05 00:00:00
abstract：:Pseudoaneurysms of the lingual artery are extremely rare and are commonly iatrogenic in nature or less frequently a result of blunt or penetrating trauma. Traditionally, these vascular abnormalities have been repaired with open or endovascular techniques. Although ultrasound-guided percutaneous thrombin injection has ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2013.10.013
更新日期：2014-07-01 00:00:00
abstract：:The treatment for obturator bypass graft infection has been rarely reported and is a surgical challenge because it is difficult to debride infected tissue around the graft located in the deep route and to ensure an alternative revascularization route in patients with a history of inguinal infection. Percutaneous conti...
journal_title：Annals of vascular surgery
pub_type：
doi：10.1016/j.avsg.2019.04.039
更新日期：2019-11-01 00:00:00
abstract：:Previous reports have suggested "short" focal stenoses in peripheral vein grafts (PVGs), namely less than 2 cm long, can be successfully balloon dilated with good long-term patency rates. We questioned if enthusiasm for balloon angioplasty of these lesions in failing PVGs is warranted. Between August 1, 1993 and Decem...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s100169900129
更新日期：1998-03-01 00:00:00
abstract：BACKGROUND:Symptomatic renal artery aneurysms at bifurcation points present challenging clinical scenarios rarely amenable to endovascular repair due to concerns regarding parenchymal loss following intervention. Herein, we add to the scant body of literature describing successful endovascular repair of a saccular, sym...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2016.10.042
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:We aimed to investigate whether the transfusion of 2 units of fresh frozen plasma (FFP) immediately post aneurysm exclusion has any effect on the perioperative fibrinogen levels and the outcome of patients undergoing elective endovascular repair (EVAR) of abdominal aortic aneurysm (AAA). METHODS:Consecutive...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2020.09.003
更新日期：2020-09-16 00:00:00
abstract：BACKGROUND:Dynamic compliance (Cd) of the adult thoracic ascending and arch aorta has had limited in vivo evaluation in patients with aortic disease. This study evaluates aortic compliance using intravascular ultrasound (IVUS) across a range of thoracic aortic diseases. METHODS:Seventy-nine patients undergoing thoraci...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2018.12.060
更新日期：2019-05-01 00:00:00
abstract：:Spontaneous dissection of the superior mesenteric artery represents a rare cause of abdominal angina. Conservative or more aggressive treatments such as surgery or endovascular therapy depend on the symptoms. We present a case report of acute mesenteric ischemia due to spontaneous dissection of the superior mesenteric...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1016/j.avsg.2008.12.004
更新日期：2009-07-01 00:00:00
abstract：:We present a case of extra-anatomic axillo-mesenteric reconstruction for chronic mesenteric ischemia. Endovascular access and retrograde bypass options were prohibited by severe aortoiliac occlusive disease. Standard antegrade bypass was impossible because of the presence of a thoracoabdominal aortic aneurysm. This un...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2015.08.005
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Despite an aggressive climate of limb salvage and revascularization, 7% of patients with peripheral artery disease undergo major lower extremity amputation (LEA). The purpose of this study was to describe the current demographics and early outcomes of patients undergoing major LEA in the Vascular Quality Ini...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2017.07.034
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Medical treatment of disabling intermittent claudication or critical limb-threatening ischemia causing rest pain often fails or has partial response. METHODS:In this pilot study, 36 patients (12 females) affected by disabling intermittent claudication or rest pain of the lower extremities were exposed to a ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.avsg.2018.01.074
更新日期：2018-05-01 00:00:00
abstract：:The pathophysiological implications of Chlamydia pneumoniae in atherosclerotic lesions and its contribution to atherosclerotic complications remain unclear. Therefore, the purpose of the present study was to evaluate whether or not there is an association between the presence of Chlamydia pneumoniae in atherosclerotic...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s10016-001-0178-5
更新日期：2002-07-01 00:00:00
abstract：:The etiology of spontaneous dissection of the carotid and vertebral arteries without antecedent trauma remains unclear. The goal of this 10-year review was to examine factors regarding presentation, diagnosis, treatment, and outcome for all patients at our institution who were diagnosed with spontaneous carotid dissec...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2006.10.020
更新日期：2007-03-01 00:00:00
abstract：:Pancreaticoduodenal artery aneurysms (PDAAs) are rare, but rupture can occur at any time regardless of the size. We describe here the case of 53-year-old woman who presented with a ruptured PDAA associated with compression of the celiac trunk by the median arcuate ligament. We first performed revascularization of the ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2017.05.007
更新日期：2017-08-01 00:00:00
abstract：:Stable coil placement is an imperative when treating arterial pathology at branch points. Coil kick and escape threaten distal organs, particularly as the pack tightens. Before the development of the VBX balloon-expandable stent graft (W.L. Gore, Flagstaff, AZ), vessel caliber change often precluded straightforward st...
journal_title：Annals of vascular surgery
pub_type：
doi：10.1016/j.avsg.2020.05.026
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Postoperative ischemic colitis (POIC) remains a frequent and extremely severe complication of infrarenal abdominal aorta surgery. However, its diagnosis and treatment are not always consensual because the incidence is very small. The aim of this retrospective study was to evaluate the prognostic factors of s...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2010.02.054
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Overtreatment and overuse of resources are leading causes of rising health care costs. Identification and elimination process of low value services is important in reducing such costs. At many institutions it is routine to send excised plaque after carotid endarterectomy (CEA) for pathology evaluation. With ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2020.04.065
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Venous resection during pancreaticoduodenectomy for the excision of pancreatic cancer allows for a more complete resection with negative margins, which increases survival. When the resected vein is greater than 3 cm, reconstruction with an interposition graft is recommended. However, consensus regarding the ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2019.11.008
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:To evaluate our experience with staged carotid endarterectomy (CEA) followed by coronary artery bypass grafting (CABG) within the perioperative period for patients with severe carotid and coronary artery disease. METHODS:From 1998 to August of 2010, 40 patients who were referred for isolated coronary surger...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2011.10.002
更新日期：2012-01-01 00:00:00
abstract：:Information about the variations of the origins of subclavian and vertebral arteries and their course is of great importance for head and neck surgery. The normal vertebral arteries arise as the first branches of the corresponding subclavian arteries. In a minority of cases, the left vertebral artery could arise direc...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2008.02.015
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Lymphatic interventions have recently been increasingly used for treating lymphatic leak of the abdomen and pelvis. This retrospective case study series and systematic review evaluated the efficacy and safety of lymphatic interventions for the treatment of postoperative lymphatic leak of the abdomen and pelv...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2020.04.063
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:This study aims to assess primary bare stenting for iliac chronic total occlusions (CTOs) with midterm follow-up. METHODS:From April 2013 to May 2016, all patients presenting with symptomatic iliac CTO were treated endovascularly and included in a prospective single-center cohort. Common iliac CTOs were tre...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2020.05.046
更新日期：2020-06-02 00:00:00
abstract：BACKGROUND:Unintentional renal artery occlusion after endovascular aortic aneurysm repair (EVAR) is an uncommon phenomenon. The sequelae from this specific complication are severe; consequently, the topic of renal artery coverage is a pertinent issue. We present a case series of patients undergoing EVAR with unintentio...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1016/j.avsg.2012.02.018
更新日期：2012-11-01 00:00:00
abstract：:A 68-year-old woman presented with signs and symptoms suggestive of a cerebrovascular accident. Her work-up revealed left internal carotid artery stenosis consistent with her presentation of a left middle cerebral artery distribution stroke. Imaging also incidentally revealed a persistent hypoglossal artery. She under...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2015.05.032
更新日期：2015-11-01 00:00:00
abstract：:This study reports our experience of using thoracoscopic cervicodorsal sympathectomy with diathermy. From December 1994 to September 1998, we performed 53 thoracoscopic sympathectomies in 35 patients. There were 15 men and 20 women, ages 18 to 61 years. Ten surgeries were performed on the right side, 7 were the left, ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s100169900302
更新日期：1999-11-01 00:00:00
abstract：:Marjolin's ulcer is an aggressive form of squamous cell carcinoma that develops over time from chronic wounds and scars, including burns and chronic venous stasis ulcers. The incidence of malignant transformation is low, resulting in a delay in diagnosis and increased morbidity and mortality in these patients. We repo...
journal_title：Annals of vascular surgery
pub_type： 杂志文章,评审
doi：10.1016/j.avsg.2013.06.002
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Almost 80% of patients with end-stage renal disease (ESRD) initiate dialysis via a central venous catheter (CVC). CVCs are associated with multiple complications and a high cost of care. The purpose of our project is to determine the impact of early cannulation arteriovenous grafts (ECAVGs) on quality of car...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2019.02.007
更新日期：2019-08-01 00:00:00
abstract：:Penetrating chest trauma is common but few need surgical treatment (10-20%). The mortality of gunshot wounds of the heart is 45%, among the wounded arriving at the hospital. The suspicion of wound heart with an inlet in the heart area (limited by costal awnings down, clavicles top, and mid-clavicular line outside) and...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2016.02.038
更新日期：2016-10-01 00:00:00
abstract：:Intimal sarcoma is a rare and aggressive vascular pathology. The literature describes about 140 cases. Because of late diagnosis, the median survival time is only a few months. Presentations vary from the localization. The most common symptoms are intravascular obstruction or embolization. Diagnosis is difficult and v...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1016/j.avsg.2014.09.022
更新日期：2015-02-01 00:00:00
abstract：:Since the introduction of endovascular stent grafts at our institution we have used intraoperative intravascular ultrasound (IVUS) to definitively determine stent graft size. In this study, expected stent graft size, based on preoperative helical CT scan measurements, was compared with the actual final size, based on ...
journal_title：Annals of vascular surgery
pub_type： 杂志文章
doi：10.1007/s100169910067
更新日期：2000-07-01 00:00:00
