Abstract：
:Following the WHO protocol for in-vivo tests in areas with intense transmission of uncomplicated falciparum malaria, a randomized comparison of the invivo efficacy of chloroquine alone, sulfadoxine/pyrimethamine alone, and their combined administration was carried out in the third quarter of 2001 in Kaberamaido District, northeastern Uganda. Malaria in the study area is hyper-endemic, with a high prevalence of Plasmodium falciparum. The patients were infants and young children with a median age of 15 months. Of the 117 originally enrolled patients, 104 had a complete follow-up with presentation at all scheduled examinations. In the chloroquine group (n = 42), 55% were classified as adequate clinical response, 26% as early treatment failure, and 19% as late clinical failure. In the sulfadoxine/pyrimethamine group (n = 30), the respective figures were 83%, 13% and 3%, and in the group with combined treatment (n = 32), 88%, 6% and 6%. In terms of clinical cure rate, speed of clinical relief and parasite clearance the combined treatment proved to be the most effective of the three drug regimens. In the patients with adequate clinical response, a significant post-therapeutic increase of the haematocrit was observed, which was particularly marked in patients who had also cleared their parasitaemia. Increase of the efficacy of chloroquine with age indicates the early development of semi-immunity in the study area, with conserved efficacy of chloroquine in semi-immune persons.
journal_name
Wien Klin Wochenschrjournal_title
Wiener klinische Wochenschriftauthors
Ogwang S,Engl M,Vigl M,Kollaritsch H,Wiedermann G,Wernsdorfer WHsubject
Has Abstractpub_date
2003-01-01 00:00:00pages
45-9eissn
0043-5325issn
1613-7671journal_volume
115 Suppl 3pub_type
临床试验,杂志文章,随机对照试验abstract：:Evaluation of the hepatitis-B data of the Austrian Workers' Compensation Board (AWCB), where the results of the serological findings of the markers HBsAg, anti-HBs and anti-HBc are stored, allows the following conclusions to be reached regarding persons employed in gynaecological departments: The average hepatitis-B i...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1987-04-17 00:00:00
abstract：:A diagram is presented which enables the continuous recording of biometric values from the earliest possible time right up to the end of pregnancy. It has been tested in practice. The duration of pregnancy and fetal development and growth can be evaluated from the diagram. ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1979-10-12 00:00:00
abstract：:The clinical variability of chronic infections due to Borrelia burgdorferi is greater than previously thought. Three personal cases are presented in an overview, together with cases from the literature. Chronic spastic para- and quadriparesis, transverse myelitis and recurrent hemiparesis have been noted in such cases...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-05 00:00:00
abstract：:2851 radiodiagnostic examinations of the skull made in a psychiatric hospital between 1958 and 1977 were reviewed for enostosis frontalis. Out of 1398 female patients there were 125 cases of enostosis frontalis, whereas out of the 1453 male there were only 5. Hence, in females, this is a frequent condition (9%) and sh...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1979-09-14 00:00:00
abstract：OBJECTIVE:Gastrointestinal side effects are the limiting factor in the prescription of non-steroidal antirheumatic drugs (NSAID). However, there are no recent data from Austria. The aim of this prevalence study was therefore to assess the gastrointestinal risk from NSAID in Austria. METHODS:A total of 1347 patients we...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/BF03040271
更新日期：2003-01-31 00:00:00
abstract：:An 84-year-old female patient was admitted to our internal medicine outpatient clinic complaining of stomach ache, nausea, and vomiting. She had hepatitis C infection for 10 years that was managed with antiviral treatment. On the second day of admission, she developed anxiety and complained about dysuria. Medazepam an...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-014-0523-7
更新日期：2014-05-01 00:00:00
abstract：:As a result of progress in the modern treatment of burns, systemic candidosis (CA), in the sense of "surviving mycoses", has become increasingly frequent. The site of entry is not usually the wound, but the intestinal tract, which becomes overgrown by the yeasts as a consequence of the requisite therapy with antibacte...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1976-11-12 00:00:00
abstract：:Urea and cyanate, spontaneously transformed from urea, are increased with decreased renal function becoming potential toxins. Isocyanic acid, the active form of cyanate, carbamoylates proteins, amino acids and other molecules, changing molecular structure and function in vivo. Carbamoylation can occur at multiple site...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：1998-08-21 00:00:00
abstract：:There is currently no accepted therapeutic regimen for patients with chronic hepatitis C who failed to respond to standard combination treatment with interferon-alpha plus ribavirin. We investigated triple combination treatment with induction dosing of interferon-alpha plus ribavirin plus amantadine in these difficult...
journal_title：Wiener klinische Wochenschrift
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/BF03217706
更新日期：2004-08-31 00:00:00
abstract：:Prostaglandins (PG) play an important role in the regulation of the renal blood flow and glomerular filtration rate. This study was designed to examine PG synthesis in the presence and absence of the ACE inhibitor captopril, PG binding to specific receptors and the ability of PG to stimulate cAMP accumulation in isola...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The radiotherapy unit of the Ist Department of Gynaecology, University of Vienna, was founded 25 years ago and its direction was entrusted to me. The initial period was extremely strenuous and difficult, especially in view of the fact that in our country the radiotherapeutic specialist in general - and the specialist ...
journal_title：Wiener klinische Wochenschrift
pub_type： 历史文章,杂志文章
doi：
更新日期：1975-07-18 00:00:00
abstract：:The author outlines the scientific works of Anton (von) Rosas (1791-1855), professor of ophthalmology in Padua and Vienna. Rosas' scientific opinions are compared with those of his teacher (G. J. Beer) and contemporaries. Three topics of medical and surgical ophthalmology have been analyzed in detail: epidemic-contagi...
journal_title：Wiener klinische Wochenschrift
pub_type： 传,历史文章,杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Whole blood selenium status of 299 persons, 144 women and 155 men, with a mean age of 62 +/- 10 years, has been determined. The individuals came from all Austrian provinces to Bad Hall to improve their heart and circulation disorders. The mean selenium content was 95 micrograms/l. We found no correlations between sele...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Plasma exchange (PE) is the treatment of choice in emergencies arising in patients suffering from the hyperviscosity syndrome, factor VIII antibody haemophilia, autoimmune haemolytic anaemia or post-transfusion purpura. Apart from these clear indications, the efficacy of PE in other hematological disorders such as thr...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1985-02-01 00:00:00
abstract：:In the newborn, presence of sleep-wake cycles indicates integrity and maturity of the central nervous system. By spectral EEG analysis and polygraphic recordings subtle variations of EEG background activity and behavioural patterns corresponding to early sleep-wake cycles have been found in preterm infants as young as...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：2001-04-17 00:00:00
abstract：BACKGROUND:Femoral short stems promise essential advantages in total hip arthroplasty. Up to now, only short- and midterm clinical studies exist. Data on early stem migration that could predict later aseptic loosening at an early stage are rare. The purpose of this study was to assess migration patterns and clinical ou...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-015-0756-0
更新日期：2015-05-01 00:00:00
abstract：:The prevalence of diabetes is increasing in westernized countries. In addition, about half of all patients suffering from diabetes are not diagnosed. The current article represents the recommendations of the Austrian Diabetes Association for the screening and prevention of type 2 diabetes, based on currently available...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：10.1007/s00508-016-0971-3
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:This study aims to answer the question to which extent even very heavy nicotine-dependent smokers can benefit from a 3-week inpatient smoking cessation program. A particular focus lies on analyzing the positive effects, which go above and beyond normally anticipated health benefits. METHODS:This is a descri...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-015-0820-9
更新日期：2015-10-01 00:00:00
abstract：:The current knowledge and recommendations on the clinical use of granulocyte colony-stimulating factors (G-CSF) in gynecologic cancers including breast cancer, along with the clinical experience of the members of the working group of the Austrian Arbeitsgemeinschaft für Gynäkologische Onkologie (AGO), have been summar...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,实务指引
doi：10.1007/s00508-012-0185-2
更新日期：2012-06-01 00:00:00
abstract：:As in other organs, homeostatic mechanisms become insufficient in the aging brain, in part because of reduced activity of various neurotransmitter systems. Counter-regulatory processes are therefore reduced and reactions to drugs may be increased. Aside from these pharmacodynamic mechanisms, the increased toxicity of ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-05 00:00:00
abstract：:We compared obstetric data from the archives in Graz for 1887 with those of 1987. In 1887, 85% of all deliveries took place in the home or with a midwife--compared with only 0.46% in 1987. Maternal mortality in 1887 was 0.75%; two-thirds of the deaths occurred in the puerperium. Perinatal mortality was 11.0% in 1887 a...
journal_title：Wiener klinische Wochenschrift
pub_type： 历史文章,杂志文章
doi：
更新日期：1989-12-22 00:00:00
abstract：:Because pulmonary embolism (PE) and its treatment carry substantial risk of morbidity and mortality, accurate diagnosis is essential. We report two cases with allergic reactions, in which PE was suggested by routine ECG and D-dimer elevation and strengthened by spiral CT. Therapy with low-molecular-weight heparin was ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/BF03040891
更新日期：2003-10-31 00:00:00
abstract：BACKGROUND:The psychometric properties of an instrument, the Activity Scale for Kids-performance (ASKp), were assessed which was proposed to capture physical functioning after allogeneic hematopoietic stem cell transplantation (HSCT). Additionally, this multicenter observational prospective study investigated the influ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,多中心研究
doi：10.1007/s00508-020-01641-w
更新日期：2021-01-01 00:00:00
abstract：:11 women gave birth to 13 live-born infants after a mean period of 39.6 months following transplantation, whereby one of these women had two successful pregnancies and one patient had a twin pregnancy. The highly premature twins, born after a complicated pregnancy with impaired renal graft function in the mother, died...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：1993-01-01 00:00:00
abstract：:Within the framework of an experimentally introduced curriculum in Medical Physiology during the past three years, voluntary tests of the multiple-choice type were offered at the end of each term in order to provide students with feedback on their achievements. Positive results contribute to the final grade. Analysis ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1979-07-13 00:00:00
abstract：:A portable insulin-infusion device (Siemens-Erlangen) was used by 24-year-old juvenile onset-type diabetic woman for a period of 5 months in order to achieve normoglycaemic conditions. The patient suffered from rapidly deteriorating florid proliferative retinopathy and was practically blind. Kidney function was seriou...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1980-04-11 00:00:00
abstract：:Adequate volume replacement therapy is a mainstay of managing the critically ill. The ideal kind of volume replacement in this situation still remains a challenge. In spite of an immense number of contributions to this problem there is still no definite answer. The ideal volume replacement strategy should not only aim...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：10.1007/BF03040482
更新日期：2004-03-31 00:00:00
abstract：:The developments in urology over the past 10 years both in regard to diagnosis and therapy are reviewed. The value of diagnostic procedures such as intravenous urography, angiography, isotope rhenogram and scintigram in tumours of the kidney and the significance of lymphangiography in the decision concerning the opera...
journal_title：Wiener klinische Wochenschrift
pub_type： 历史文章,杂志文章
doi：
更新日期：1976-02-20 00:00:00
abstract：:In a prospective study, 60 patients with allergic rhinoconjunctivitis and/or asthma due to house dust mites were chosen for hyposensitization treatment with Migen (M) or Pharmalgen (P). Immunotherapy stretched over a whole year and every 3 months clinical results were evaluated by the patient's symptom score, by resul...
journal_title：Wiener klinische Wochenschrift
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1989-08-04 00:00:00
abstract：:12 patients with chronic bronchitis were treated with two different doses (0.02 and 0.08 mg) of Sch 1000 (Atrovent) administered by metered dose inhalation and the results compared with those following administration of a placebo in a cross-over double-blind study. The airway resistance and thoracic gas volume fell si...
journal_title：Wiener klinische Wochenschrift
pub_type： 临床试验,杂志文章
doi：
更新日期：1975-02-21 00:00:00
