Phrynoderma: a manifestation of vitamin A deficiency?... The rest of the story.

Abstract:

:Phrynoderma is a distinctive form of follicular hyperkeratosis associated with nutritional deficiency. Although originally thought to represent vitamin A deficiency, several studies have demonstrated multiple etiologies. Characteristic skin lesions are hyperkeratotic papules that first appear on the extensor surfaces of the extremities, shoulders, and buttocks. We report a 14-month-old boy with malnourishment and hyperkeratotic papules and plaques with histologic changes typical of phrynoderma. Despite an extensive evaluation, a specific nutritional deficiency was not identified. Phrynoderma is believed to be a manifestation of severe malnutrition, not necessarily accompanying low vitamin A levels. While the literature supports a link between phrynoderma and vitamins E, B, A, and essential fatty acids general malnutrition seems to be the strongest association. The clinical picture typically improves with enhanced nutritional status. Phrynoderma must be considered in the differential diagnosis in patients with extensor surface hyperkeratotic papules and plaques in the setting of malnourishment and should prompt the clinician to evaluate cell markers of nutritional status, not just vitamin A. We believe this patient exemplifies the conundrum that faces clinicians in evaluating patients with extensor surface predominant hyperkeratotic papules and plaques in the setting of malnourishment.

journal_name

Pediatr Dermatol

journal_title

Pediatric dermatology

authors

Maronn M,Allen DM,Esterly NB

doi

10.1111/j.1525-1470.2005.22113.x

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

60-3

issue

1

eissn

0736-8046

issn

1525-1470

pii

PDE22113

journal_volume

22

pub_type

杂志文章
  • Gianotti-Crosti syndrome following childhood vaccinations.

    abstract::A 19-month-old boy was evaluated for a skin eruption after recent vaccinations. Clinical and histopathologic findings supported a diagnosis of Gianotti-Crosti syndrome (GCS). This case report examines the link between GCS and vaccinations, particularly the diphtheria, tetanus, and pertussis vaccine and the varicella v...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-1470.2011.01636.x

    authors: Retrouvey M,Koch LH,Williams JV

    更新日期:2013-01-01 00:00:00

  • Fibroadipose vascular anomaly treated with sirolimus: Successful outcome in two patients.

    abstract::Fibroadipose vascular anomaly (FAVA) is a rare, complex mesenchymal malformation combining fibrofatty replacement of the affected muscles and slow-flow vascular malformation. The condition is characterized by localized swelling, severe pain, phlebectasia, and contracture of the affected limb. Treatment paradigms are n...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.13260

    authors: Erickson J,McAuliffe W,Blennerhassett L,Halbert A

    更新日期:2017-11-01 00:00:00

  • Microbiology of nonbullous impetigo.

    abstract::Our objective was to establish the aerobic and anaerobic microbiology of nonbullous impetigo (NI) in children. We used a retrospective review of clinical microbiology laboratory and patients' records. Specimens were obtained from 40 patients with NI lesions and showed bacterial growth. Aerobic or facultative anaerobic...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.1997.tb00235.x

    authors: Brook I,Frazier EH,Yeager JK

    更新日期:1997-05-01 00:00:00

  • PHACE syndrome with growth hormone deficiency and absence of bilateral internal carotid arteries: a case report.

    abstract::PHACE syndrome is characterized by posterior fossa malformations (P), large facial hemangiomas (H), arterial anomalies (A), cardiac anomalies or coarctation of aorta (C), and eye anomalies (E) and has striking female predominance. Endocrine abnormalities have recently been described in these patients, involving the th...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.2011.01540.x

    authors: Altin H,Alp H,Sap F,Karataş Z,Baysal T,Karaaslan S

    更新日期:2012-05-01 00:00:00

  • Isotretinoin-induced acne fulminans without systemic symptoms with concurrent exuberant granulation tissue.

    abstract::Acne fulminans is a severe form of acne characterized by painful, inflammatory nodules that progress into ulcers and concurrent systemic symptoms. Treatment of acne with isotretinoin can precipitate a syndrome called isotretinoin-induced acne fulminans without systemic symptoms. An exuberant granulation tissue respons...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.13389

    authors: Li AW,Antaya RJ

    更新日期:2018-03-01 00:00:00

  • Vesicular erythema multiforme-like reaction to para-phenylenediamine in a henna tattoo.

    abstract::Allergic contact dermatitis reaction to topical "black henna" tattoo is usually described secondary to the organic dye para-phenylenediamine, a derivative of analine. Allergic contact dermatitis reactions to para-phenylenediamine are well recognized and most commonly involve an eczematous reaction that may become gene...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.2008.00634.x

    authors: Sidwell RU,Francis ND,Basarab T,Morar N

    更新日期:2008-03-01 00:00:00

  • Epidermal nevus syndromes: New insights into whorls and swirls.

    abstract::Knowledge of the molecular underpinnings of many epidermal nevi and epidermal nevus syndrome has expanded rapidly in recent years. In this review and update on epidermal nevus syndrome, we will cover recent genetic discoveries involving epidermal nevi, including nevus sebaceus, keratinocytic epidermal nevus, nevus com...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/pde.13273

    authors: Asch S,Sugarman JL

    更新日期:2018-01-01 00:00:00

  • Diffuse normolipemic plane xanthoma in a 9-year-old boy.

    abstract::Normolipemic plane xanthoma normally occurs in adults. We report the atypical instance of a 9-year-old boy who developed disseminated, flat, yellow-brown plaques up to 2 to 3 cm without any complaints. The histology showed the hallmarks of xanthoma, including the presence of CD68+ foam cells and Touton giant cells. No...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.2005.22207.x

    authors: Hofmann M,Zappel K,Trefzer U,Audring H,Albrecht-Nebe H,Sterry W,Blume-Peytavi U

    更新日期:2005-03-01 00:00:00

  • Frequency and severity of diaper dermatitis with use of traditional Chinese cloth diapers: observations in 3- to 9-month-old children.

    abstract::Chinese cloth diapers differ from disposable diapers in several respects that are central to our understanding of the etiology of diaper dermatitis (DD), yet there are no published reports on the dermatological correlates of this manner of infant care, which is prevalent among the world's second-largest pediatric popu...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.2011.01494.x

    authors: Liu N,Wang X,Odio M

    更新日期:2011-07-01 00:00:00

  • Infantile myofibroma in a prematurely born twin: a case report.

    abstract::Infantile myofibromatosis is a rare benign tumor of infancy and childhood that occurs in solitary, multiple, and generalized forms with similar histology but different clinicopathologic and prognostic implications. Even solitary tumors need follow-up, as the type of presentation will be determined over time. It is nec...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1525-1470.2003.20416.x

    authors: Jurcić V,Perković T,Pohar-Marinsek Z,Hvala A,Lazar I

    更新日期:2003-07-01 00:00:00

  • Tuberous sclerosis with macrodactyly.

    abstract::Tuberous sclerosis with macrodactyly is a very uncommon presentation. We report a 15-year-old girl with a thick, loose hyperpigmented area on the dorsum of the left hand with macrodactyly. A skin biopsy specimen from the dorsum of the left hand revealed dense collagenization in the dermis. Radiographs showed marked ir...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1525-1470.2000.01821.x

    authors: Sahoo B,Handa S,Kumar B

    更新日期:2000-11-01 00:00:00

  • Papulolinear collagenoma with arborizing arrangement: report of a case.

    abstract::Connective tissue nevi of collagen type are now classified in four major subtypes. In addition to the clinicopathological features of papulolinear collagenoma, which is considered as a variant of isolated collagen harmatoma, the case we present has a unique arborizing pattern. ...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.2008.00842.x

    authors: Lo LK,Tsai TF,Chen YF,Hung CM,Ko WC

    更新日期:2009-01-01 00:00:00

  • Cutaneous manifestations of diabetes mellitus in children.

    abstract::This article reviews skin changes occurring in diabetic children. Skin changes may be related to metabolic alterations associated with diabetes. Others may be manifestations of macro or microvascular disease. Insulin injections, required for management of most diabetes in the pediatric age group, may also cause cutane...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-1470.1985.tb01047.x

    authors: Edidin DV

    更新日期:1985-03-01 00:00:00

  • Follicular Mucinosis in a Male Adolescent with a History of Acute Myelogenous Leukemia and Graft-versus-Host Disease.

    abstract::Although many cases of follicular mucinosis are idiopathic, numerous others are associated with mycosis fungoides or, rarely, other neoplastic or inflammatory disorders. There are only three reported cases, all in adults, of follicular mucinosis arising in association with acute myelogenous leukemia, two of which invo...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.12724

    authors: Jefferson J,Taube J,Grossberg A

    更新日期:2016-01-01 00:00:00

  • Agminated segmental plaque-type blue nevus associated with hypertrichosis and soft tissue hypertrophy: Report of a case and review of the literature.

    abstract::Blue nevi are common skin neoplasms that typically present as asymptomatic solitary papules, although they may rarely occur in an agminated configuration. We describe a case of agminated blue nevus in a segmental facial distribution associated with soft tissue hypertrophy and hypertrichosis in a 16-year-old boy and pr...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/pde.13303

    authors: Hunjan MK,Mohandas D,Bridges AG,Tollefson M

    更新日期:2018-01-01 00:00:00

  • Dermoscopy distinction of eruptive vellus hair cysts with molluscum contagiosum and acne lesions.

    abstract::Eruptive vellus hair cysts are benign lesions that can be difficult to distinguish from other skin conditions, including molluscum contagiosum and acne vulgaris. Diagnosis can be corroborated with histopathology. We emphasize differing dermoscopy features to help distinguish eruptive vellus hair cysts from molluscum c...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.2012.01771.x

    authors: Alfaro-Castellón P,Mejía-Rodríguez SA,Valencia-Herrera A,Ramírez S,Mena-Cedillos C

    更新日期:2012-11-01 00:00:00

  • Lymphangioma circumscriptum treated with pulsed dye laser.

    abstract::Lymphangioma circumscriptum is a lymphatic malformation that involves the skin and may extend to subcutaneous tissue and muscle. Treatment of these lesions is challenging. Surgical excision may be performed but recurrence is common. Herein we report a child with a symptomatic lymphangioma circumscriptum that was treat...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1525-1470.2001.1862001.x

    authors: Lai CH,Hanson SG,Mallory SB

    更新日期:2001-11-01 00:00:00

  • Sporadic cases of Heck disease in two Polish girls: association with human papillomavirus type 13.

    abstract::Two sporadic cases of Heck disease in Polish girls were associated with human papillomavirus 13. No other children and nobody from their surroundings had similar lesions. The course of the disease was chronic in both patients. The lesions regressed spontaneously in one girl within several years after some of the papul...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.1993.tb00368.x

    authors: Obalek S,Janniger C,Jablonska S,Favre M,Orth G

    更新日期:1993-09-01 00:00:00

  • Should we biopsy melanonychia striata in Asian children? A retrospective observational study.

    abstract:BACKGROUND AND OBJECTIVES:Melanonychia striata is common in children of darker-skinned Asian races, while subungual melanoma is extremely rare and it is difficult to make a diagnosis clinically. However, performing nail unit biopsies in children is particularly challenging and can result in permanent nail dystrophy. Th...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.13934

    authors: Colin Tan W,Wang DY,Seghers AC,Koh MJA,Nicholas Goh SG,Joyce Lee SS

    更新日期:2019-11-01 00:00:00

  • Diaper dermatitis prevalence and severity: Global perspective on the impact of caregiver behavior.

    abstract:OBJECTIVES:To compare prevalence and severity of diaper dermatitis (DD) in infants and toddlers (babies) across three countries (China, USA, and Germany), including diapered skin measures and caregiver practices. METHODS:A cross-sectional study of 1791 babies (~600 from each country) was recruited at each clinical sit...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.14047

    authors: Carr AN,DeWitt T,Cork MJ,Eichenfield LF,Fölster-Holst R,Hohl D,Lane AT,Paller A,Pickering L,Taieb A,Cui TY,Xu ZG,Wang X,Brink S,Niu Y,Ogle J,Odio M,Gibb RD

    更新日期:2020-01-01 00:00:00

  • Skin cancer prevention counseling and clinical practices of pediatricians.

    abstract::Little is known about pediatricians' counseling and clinical practices to reduce skin cancer risk among their patients. Thus our objectives were to characterize skin cancer preventive counseling and clinical practices in a sample of pediatricians and identify correlates of these practices. Physicians practicing genera...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1525-1470.2003.03004.x

    authors: Gritz ER,Tripp MK,de Moor CA,Eicher SA,Mueller NH,Spedale JH

    更新日期:2003-01-01 00:00:00

  • Open Microcomedone Extraction Facilitated by Polarized Dermoscopy.

    abstract::Microcomedonal lesions can be aesthetically and psychologically displeasing. The burden of comedones increases when considering their frequency and demand for time-consuming attention. The objective of the current study was to describe a novel technique to facilitate open microcomedone extraction. The instrumentation ...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.12978

    authors: Naimer SA

    更新日期:2016-11-01 00:00:00

  • Radiation Recall Dermatitis Secondary to Dactinomycin.

    abstract::Radiation recall dermatitis (RRD) is an uncommon reaction typically triggered by the use of chemotherapeutic agents in the months after treatment with radiation therapy. It usually presents as dermatitis in the irradiated field with prominent intertriginous involvement, and because internal involvement occurs in up to...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.12903

    authors: Prindaville B,Horii KA,Canty KM

    更新日期:2016-09-01 00:00:00

  • Cutaneous ultrasound and its utility in Pediatric Dermatology: Part II-Developmental anomalies and vascular lesions.

    abstract::High-frequency ultrasonography represents a promising tool for pediatric dermatologists. It is a noninvasive and harmless diagnostic technique that is especially appealing when working with children. It can be easily performed at the patient's bedside, avoiding diagnostic delays, sedation, or multiple visits. It repre...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/pde.13897

    authors: Rodríguez Bandera AI,Sebaratnam DF,Feito Rodríguez M,de Lucas Laguna R

    更新日期:2020-01-01 00:00:00

  • Sequestrated meningocele of the scalp: diagnostic value of hair anomalies.

    abstract::Clinical aspects of sequestrated meningocele can be varied, causing difficulties in histopathological diagnosis. The meningeal tissue is scanty and appears as nonspecific connective tissue, therefore it may be overlooked. One classical and two unusual clinical presentations of sequestrated meningocele are described: o...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.1994.tb00095.x

    authors: Khallouf R,Fétissof F,Machet MC,Stephanov E,Lechrist J,Lorette G

    更新日期:1994-12-01 00:00:00

  • Serum sickness-like reaction in children due to cefditoren.

    abstract::We describe the case of a 7-year-old boy with urticaria, fever, and arthritis that appeared 10 days after starting cefditoren therapy for acute tonsillopharyngitis, which was diagnosed as a serum sickness-like reaction due to this medication. ...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.2011.01539.x

    authors: Misirlioglu ED,Duman H,Ozmen S,Bostanci I

    更新日期:2012-05-01 00:00:00

  • Crohn's disease of the vulva in an 8-year-old girl.

    abstract::An 8-year-old girl had Crohn's disease of the vulva 16 months before the onset of intestinal symptoms. At the time of diagnosis she had no evidence of systemic disease. Cutaneous and intestinal lesions responded rapidly to corticosteroids and metronidazole. Crohn's disease must be considered in the differential diagno...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.1988.tb01148.x

    authors: Lally MR,Orenstein SR,Cohen BA

    更新日期:1988-05-01 00:00:00

  • Somatic Mosaicism for a "Lethal" GJB2 Mutation Results in a Patterned Form of Spiny Hyperkeratosis without Eccrine Involvement.

    abstract:BACKGROUND:Spiny hyperkeratosis refers to a rare clinical phenotype characterized by nonfollicular keratotic projections and sometimes associated with other acquired and inherited conditions. We describe a case of congenital patterned spiny hyperkeratosis. METHODS:To identify the cause of this disorder, we used a comb...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/pde.12848

    authors: Eskin-Schwartz M,Metzger Y,Peled A,Weissglas-Volkov D,Malchin N,Gat A,Vodo D,Mevorah B,Shomron N,Sprecher E,Sarig O

    更新日期:2016-05-01 00:00:00

  • Hoyeraal-Hreidarsson Syndrome: An Extremely Rare Dyskeratosis Congenita Phenotype.

    abstract::Hoyeraal-Hreidarsson syndrome is a rare telomere biology disorder that is recognized as a severe variant of dyskeratosis congenita. We present a Libyan boy with hematologic and neurologic abnormalities with typical dermatologic manifestations of dyskeratosis congenita. Death usually occurs before the age of 4 years as...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/pde.12693

    authors: Bakar Ö,Işik U,Canpolat C,Alanay Y

    更新日期:2015-11-01 00:00:00

  • Unnecessary milk elimination diets in children with atopic dermatitis.

    abstract::Milk elimination diets are frequently adopted in the treatment of atopic dermatitis, although the real prevalence of clinically relevant food allergy remains unclear and reports from different authors are often in disagreement. We investigated the percentage of children allergic to cow's milk compared with the rate of...

    journal_title:Pediatric dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1525-1470.2007.00323.x

    authors: Sinagra JL,Bordignon V,Ferraro C,Cristaudo A,Di Rocco M,Amorosi B,Capitanio B

    更新日期:2007-01-01 00:00:00