Effect of allopurinol on the survival of experimental pig flaps.

Abstract:

:Allopurinol has been reported to improve cell survival in a variety of conditions, including the ischemia-reperfusion injury occurring in skin flaps. It has been suggested that the beneficial effect of allopurinol on rat skin flaps is through blockage of xanthine oxidase-generated oxygen-derived free radicals. We have previously reported on the lack of xanthine oxidase activity in the skin of humans and pigs as compared with that of rats. This current study attempts to improve skin and myocutaneous flap survival in pigs in two separate experiments using allopurinol. In the first experiment, a suspension of 50 mg/kg (N = 12) allopurinol resulted in no significant difference in the survival of control and treated flaps. Because of the negative results in the first experiment, a second experiment was designed making several changes. The length of the global ischemic insult was reduced from 8 to 6 hours, and allopurinol was administered as a solution of 300 mg/kg (N = 14). This higher dose is expected to produce complete inhibition of xanthine oxidase in this animal model. These changes resulted in three operative deaths, no improvement in skin-flap survival, and a decrease in myocutaneous flap survival. Allopurinol's therapeutic effectiveness and its mechanism of action in an ischemia-reperfusion injury model lacking xanthine oxidase activity are discussed.

journal_name

Plast Reconstr Surg

authors

Picard-Ami LA Jr,MacKay A,Kerrigan CL

doi

10.1097/00006534-199206000-00016

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

1098-103

issue

6

eissn

0032-1052

issn

1529-4242

journal_volume

89

pub_type

杂志文章
  • Reconstruction of the superior labial sulcus in secondary bilateral cleft lip deformities: an inverted U-shaped flap.

    abstract::A shallow buccal sulcus deformity following bilateral cleft lip repair is not rare. A variety of techniques are described for the secondary reconstruction of a deficient sulcus. Most of these are associated with a variable amount of contraction with subsequent obliteration of the sulcus. In this article, an inverted U...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200112000-00004

    authors: Erol OO,Ağaoğlu G

    更新日期:2001-12-01 00:00:00

  • Experimental effects of heparin or magnesium sulfate on the patency of microvascular anastomoses.

    abstract::Partial amputations of the hind legs were done in 44 rats. The femoral arteries and veins were repaired by microvascular techniques. The systemic use of heparin, the local use of magnesium sulfate, and the combined use of the two drugs, were evaluated as to their influence on preventing thrombosis in these microvascul...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197505000-00018

    authors: Engrav LH,Benjamin CI,Crandall H,Perry JF

    更新日期:1975-05-01 00:00:00

  • An Appraisal of the Cephalic Index in Sagittal Craniosynostosis, and the Unseen Third Dimension.

    abstract:BACKGROUND:The cephalic index is often used to evaluate sagittal craniosynostosis corrections; however, validation of this measure remains untested. METHODS:A three-part study was designed to (1) determine the normal distribution of cephalic indices in untreated sagittal craniosynostosis; (2) examine index values in t...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000003422

    authors: Fearon JA,Ditthakasem K,Herbert M,Kolar J

    更新日期:2017-07-01 00:00:00

  • Diced cartilage grafts in rhinoplasty surgery.

    abstract::The use of diced cartilage grafts in rhinoplasty surgery was recently revived by Erol with the publication of his technique for "Turkish delight" grafts (i.e., diced cartilage grafts wrapped in Surgicel). The present study details the authors' experience with 50 consecutive diced cartilage grafts used in three configu...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000122544.87086.b9

    authors: Daniel RK,Calvert JW

    更新日期:2004-06-01 00:00:00

  • What's New in Cleft Palate and Velopharyngeal Dysfunction Management?

    abstract:LEARNING OBJECTIVES:After studying this article, the participant should be able to: 1. Have a clear understanding of the evolution of concepts of velopharyngeal dysfunction, especially as it relates to patients with a cleft palate. 2. Explain the subjective and objective evaluation of speech in children with velopharyn...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0000000000003335

    authors: Naran S,Ford M,Losee JE

    更新日期:2017-06-01 00:00:00

  • Evaluation of plastic surgery training programs: integrated/combined versus independent.

    abstract:BACKGROUND:The authors aimed to differentiate between combined/integrated and independent (traditional) methods of plastic surgery training with regard to quality of trainees, caliber of graduates, and practice or career outcomes once graduated. METHODS:To compare combined/integrated with independent residency program...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e318254b3d0

    authors: Roostaeian J,Fan KL,Sorice S,Tabit CJ,Liao E,Rahgozar P,Tanna N,Bradley JP

    更新日期:2012-07-01 00:00:00

  • Effects of 8-Gy radiation on the microcirculation of muscle flaps in the rat.

    abstract::Combination of radical excision and radiation has been used as a treatment modality for cancer patients. As a result, in reconstructive surgery there is often a need to harvest flaps in the vicinity of previously irradiated tissues. Radiation has been shown to cause progressive injury to the macrocirculation and micro...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199910000-00020

    authors: Siemionow M,Mee J,Porvasnik S,Krapohl BD,Ozer K,Piza P,Zins JE

    更新日期:1999-10-01 00:00:00

  • The Efficacy of Intense Pulsed Light Therapy in Postoperative Recovery from Eyelid Surgery.

    abstract:BACKGROUND:The purpose of this study was to evaluate the efficacy of postoperative intense pulsed light therapy on patients who undergo bilateral eyelid surgery. METHODS:Patients presenting over a 3-month period for bilateral eyelid surgery were asked to participate in an institutional review board-approved study. Int...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/PRS.0000000000002086

    authors: Linkov G,Lam VB,Wulc AE

    更新日期:2016-05-01 00:00:00

  • Polydioxanone Threads for Facial Rejuvenation: Analysis of Quality Variation in the Market.

    abstract:BACKGROUND:Beside botulinum-toxin injections and hyaluronic acid fillers, thread lifts have established themselves as the third column of minimally invasive facial rejuvenation. Most commonly, barbed threads for this approach are made out of polydioxanone, a material known for decades from application in resorbable sut...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000006289

    authors: Aitzetmueller MM,Centeno Cerdas C,Nessbach P,Foehr P,Brett E,Thor D,Machens HG,Burgkart R,Duscher D

    更新日期:2019-12-01 00:00:00

  • Infracture technique for reduction malarplasty with a short preauricular incision.

    abstract::The infracture technique for reduction malarplasty has been widely used as an aesthetic surgical procedure in northeast Asia. Since 1988, the authors' original method of infracture technique was performed through the combined approach of intraoral and temporopreauricular incision, which may leave a rather long scar on...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000110217.60491.56

    authors: Yang DB,Chung JY

    更新日期:2004-04-01 00:00:00

  • Restoring abdominal wall integrity in contaminated tissue-deficient wounds using autologous fascia grafts.

    abstract::Necrotizing abdominal wall infections, enteric fistulae, or exposed prosthetic material after ventral hernia repair often results in a loss of abdominal wall integrity. Further surgical reconstruction with prosthetic material is usually contraindicated in the contaminated wound because of the high infection rate neces...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199804040-00014

    authors: Disa JJ,Goldberg NH,Carlton JM,Robertson BC,Slezak S

    更新日期:1998-04-01 00:00:00

  • Syngeneic Transplantation of Rat Olfactory Stem Cells in a Vein Conduit Improves Facial Movements and Reduces Synkinesis after Facial Nerve Injury.

    abstract:BACKGROUND:Posttraumatic facial paralysis is a disabling condition. Current surgical management by faciofacial nerve suture provides limited recovery. To improve the outcome, the authors evaluated an add-on strategy based on a syngeneic transplantation of nasal olfactory stem cells in a rat model of facial nerve injury...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000007367

    authors: Bense F,Montava M,Duclos C,Bisson A,Delarue Q,Mardion NB,Boyer O,Féron F,Guérout N,Marie JP

    更新日期:2020-12-01 00:00:00

  • The graft-to-capacity ratio: volumetric planning in large-volume fat transplantation.

    abstract:BACKGROUND:Variability in large-volume fat transplantation has been linked to technique. Meanwhile, the recipient-site volume and its relation to the volume of grafted fat have been relatively overlooked. Graft-to-capacity concepts are evidenced in other soft-tissue transplantation procedures such as skin and hair tran...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000438471.23249.6e

    authors: Del Vecchio DA,Del Vecchio SJ

    更新日期:2014-03-01 00:00:00

  • Rule of thumb criteria for tongue-lip adhesion in Pierre Robin anomalad.

    abstract::Rule of thumb criteria for tongue-lip adhesion in the Pierre Robin anomalad have been formulated on the basis of a review of 38 cases. Babies with this anomalad who do not show a progressive gain in strength and weight after 7 days of nonoperative intensive care or who cannot be successfully extubated after 3 days sho...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198208000-00017

    authors: Parsons RW,Smith DJ

    更新日期:1982-08-01 00:00:00

  • Effect of Body Mass Index on Outcomes after Prepectoral Breast Reconstruction.

    abstract:BACKGROUND:Body mass index has been shown to be a predictor of outcomes after subpectoral expander/implant reconstruction, with every unit increase in body mass index increasing the risk of complications by approximately 6 percent. The effect of body mass index on complications after prepectoral reconstruction has not ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000005901

    authors: Gabriel A,Sigalove S,Sigalove NM,Storm-Dickerson TL,Pope N,Rice J,Maxwell GP

    更新日期:2019-09-01 00:00:00

  • Use of Roof-Shaped Costochondral Cartilage for Correction of Saddle Nose Deformity.

    abstract:BACKGROUND:Cartilage grafts are routinely used in secondary and posttraumatic rhinoplasty. However, in most cases, there are weak areas in the nasal bones and upper lateral cartilages. The purpose of this study was to seek a solution for the keystone area and dorsum of the nose in revision and posttraumatic rhinoplasty...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000004459

    authors: Irmak F,Yazar SK,Sirvan SS,Yazar M,Karsidag S

    更新日期:2018-07-01 00:00:00

  • A novel mouse model of cutaneous radiation injury.

    abstract:BACKGROUND:Radiation therapy is a cornerstone of oncologic treatment. Skin tolerance is often the limiting factor in radiotherapy. To study these issues and create modalities for intervention, the authors developed a novel murine model of cutaneous radiation injury. METHODS:The dorsal skin was isolated using a low-pre...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181fed4f7

    authors: Thanik VD,Chang CC,Zoumalan RA,Lerman OZ,Allen RJ Jr,Nguyen PD,Warren SM,Coleman SR,Hazen A

    更新日期:2011-02-01 00:00:00

  • Transfer of the pronator quadratus motor branch for wrist extension reconstruction in brachial plexus palsy.

    abstract:BACKGROUND:In extended upper-type lesions of the brachial plexus, nerve transfers and root grafting have improved the results of shoulder and elbow reconstruction. However, wrist extension reconstruction has received little attention. METHODS:In 20 cadaveric upper limbs, we dissected the anterior interosseous nerve an...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e31826d16cf

    authors: Bertelli JA,Tacca CP,Winkelmann Duarte EC,Ghizoni MF,Duarte H

    更新日期:2012-12-01 00:00:00

  • Lymph Flow Restoration after Tissue Replantation and Transfer: Importance of Lymph Axiality and Possibility of Lymph Flow Reconstruction without Lymph Node Transfer or Lymphatic Anastomosis.

    abstract:BACKGROUND:The lymph system plays important roles in maintaining fluid balances, the immune system, and lipid metabolism. After tissue replantation or transfer, some cases suffer long-lasting edema or lymphedema caused by interruption of main lymph flows; however, this mechanism has yet to be clarified. METHODS:The me...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000004694

    authors: Yamamoto T,Iida T,Yoshimatsu H,Fuse Y,Hayashi A,Yamamoto N

    更新日期:2018-09-01 00:00:00

  • The effect of perioperative adriamycin on skin-graft take and adherence in the rat.

    abstract::This two-part study was undertaken to evaluate the effect of perioperative Adriamycin on skin-graft take and adherence in an animal model. Thirty-four male Fisher rats were divided into control and experimental groups. The controls received intravenous saline, and the experimental animals received Adriamycin 6 mg/kg (...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Nappi JF,Falcone RE,Ruberg RL,Innes JA

    更新日期:1984-09-01 00:00:00

  • J. G. Hierzel: a lip-switch flap in 1756.

    abstract::After reviewing the historical aspects of the various lip-switch flaps, the authors draw attention to the existence of a report of a lip-switch flap performed in Sweden in 1756 by J.G.Hierzel. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 传,历史文章,杂志文章

    doi:

    authors: Vrebos J,Dupuis C

    更新日期:1994-01-01 00:00:00

  • Multiple occurrence of pilomatrixoma.

    abstract::Multiple occurrences of pilomatrixoma are rare. Although it has been known as a benign lesion, there are reports of some tumors that have histopathologic features of malignancy. A case of a 68-year-old Caucasian women with multiple pilomatrixoma is presented. She was operated on to remove three other pilomatrixomas on...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199609000-00024

    authors: Aslan G,Erdoğan B,Aköz T,Görgü M,Seçkin S,Terzioğlu A

    更新日期:1996-09-01 00:00:00

  • Application of botulinum toxin type A in myocutaneous flap expansion.

    abstract:BACKGROUND:Although the use of the expanded myocutaneous flap has many advantages, the time course is prolonged. The net gain in surface area during acute expansion is insufficient. In this study, botulinum toxin type A was applied to shorten the flap expansion period while obtaining an adequate surface area that would...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181b989be

    authors: Chenwang D,Shiwei B,Dashan Y,Qiang L,Bin C,Muxin Z,Pengcheng L,Senkai L

    更新日期:2009-11-01 00:00:00

  • Novel techniques for the surgical management of abdominopelvic constriction rings in amniotic band syndrome.

    abstract::Constriction rings are associated with amniotic band syndrome and most often present in the extremities. Constriction bands of the trunk are rare, and a standard of surgical care remains elusive. Traditional methods of constriction ring excision rely on soft-tissue rearrangement with multiple Z-plasties, but renewed i...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000000903

    authors: Capone AC,Balasundaram N,Caouette-Laberge L,Papay FA,Lucas AR,Seifarth FG,Doumit GD

    更新日期:2015-02-01 00:00:00

  • Syndactylic toe transfer for fingertip reconstruction.

    abstract::In the case of multiple fingertip reconstruction requiring toe transfer, double toes can be elevated in the syndactylic fashion with a single vascular pedicle for transfer, followed by separation a few weeks later. The biggest advantage of this procedure is that the problem of limitation of recipient arteries for mult...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Hirasé Y,Kojima T,Takeishi M,Konno M

    更新日期:1995-03-01 00:00:00

  • The usability of the upper eyelid crease approach for correction of medial orbital wall blowout fracture.

    abstract:BACKGROUND:There are many approaches to the medial orbital wall. However, most of them have problems with limitation of exposure, scarring, and postoperative inflammatory symptoms related to the eye. The authors used an upper eyelid crease approach to overcome these problems and investigate the usefulness of this appro...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e318262f3d9

    authors: Kim HS,Kim SE,Evans GRD,Park SH

    更新日期:2012-10-01 00:00:00

  • Umbilical transposition in TRAM flap: a simple horizontal translocation.

    abstract::A simple method of umbilical repositioning by incising the anterior rectus sheath and rectus abdominis muscle is reported for cases of unilateral abdominal wall plication during the TRAM flap operation. This method keeps the umbilicus stable and nonstenotic, and it avoids hypertrophic scars, which result from other te...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199912000-00029

    authors: Raveh T,Gordon CB,del Campo AF

    更新日期:1999-12-01 00:00:00

  • Refinements in face lifting: enhanced facial contour using vicryl mesh incorporated into SMAS fixation.

    abstract::As we have gained experience with the extended superficial musculoaponeurotic system (SMAS) technique in face lifting, refinements in our procedure have led to increased consistency in results. The important factors that have led to our technical modifications include the following: (1) the significance of the retaini...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200001000-00046

    authors: Stuzin JM,Baker TJ,Baker TM

    更新日期:2000-01-01 00:00:00

  • Needle aspiration and pressure sutures for auricular pseudocyst.

    abstract::Auricular pseudocyst is an asymptomatic cystic swelling of the upper portion of the auricle. Various therapeutic approaches have been employed with variable success. We report our results with nine patients treated by needle aspiration and bolstered pressure sutures applied over both aspects of the cyst for 1 week. Tr...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199104000-00030

    authors: Ophir D,Marshak G

    更新日期:1991-04-01 00:00:00

  • Why some patients are unhappy: part 2. Relationship of nasal shape and trauma history to surgical success.

    abstract:BACKGROUND:A previous report indicated that secondary rhinoplasty patients with normal preoperative noses displayed significantly higher prevalences of depression, demanding behavior, previous aesthetic operations, and confirmed trauma (abuse/neglect) histories than patients who originally had dorsal deformities or str...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000000552

    authors: Constantian MB,Lin CP

    更新日期:2014-10-01 00:00:00