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Identification and in silico analysis of a new group of double-histone fold-containing proteins.

Abstract：

:The double-histone fold is a rare protein fold in which two consecutive regions characterized by the typical structure of histones assemble together, thus giving a histone pseudodimer. Previously, this fold was found in a few prokaryotic histones and in the regulatory region of guanine-nucleotide exchange factors of the Sos family. Standard methods of sequence comparison did not allow us to find new proteins containing a histone pseudodimer, as previously reported (Sondermann et al. 2003). However, a deeper investigation of protein sequences showed that the two histone folds included in Sos proteins share significant sequence similarity with nucleosomal histones. On the basis of this observation, we applied a specific strategy of sequence-homology search, which led to the identification of a new group of histone pseudodimers in Cca3 and proteins similar to Cca3 (Cca3S). A homology model of the histone pseudodimer included in rat Cca3 was constructed. A subsequent structure-function relationship study revealed that the histone pseudodimers included in Cca3 and Cca3S proteins, but not those present in Sos proteins, could retain the ability of mediating protein-DNA interactions, and could consequently act as DNA-binding modules.

journal_name

J Mol Model

journal_title

Journal of molecular modeling

authors

Greco C,Sacco E,Vanoni M,De Gioia L

doi

10.1007/s00894-005-0008-8

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

76-84

issue

1

eissn

1610-2940

issn

0948-5023

journal_volume

12

pub_type

杂志文章

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