Effects of recombinant human tumor necrosis factor on rodent gliomas and normal brain.


:In a study examining the possible therapeutic effects of recombinant human tumor necrosis factor-alpha (rHuTNF-alpha) on malignant gliomas without expression of tumor necrosis factor (TNF)-receptors, RG-2 glioma cells were tested in vitro as well as in a rat experimental glioma model. A growth inhibition assay revealed no inhibiting effect in vitro up to a concentration of 20 micrograms/ml rHuTNF-alpha. Receptor-binding studies showed that RG-2 cells did not present specific receptors for rHuTNF-alpha. The pharmacokinetics of rHuTNF-alpha after intravenous injection were studied with respect to serum, tissue, and brain tumor concentrations and showed increased glioma concentrations of (mean +/- standard error of the mean) 0.47 +/- 0.18 ng TNF/mg brain compared to 0.15 +/- 0.05 ng TNF/mg brain in the normal contralateral hemisphere. No therapeutic effect on solid RG-2 gliomas could be observed after stereotactic injection of 7.3 micrograms rHuTNF/10 microliter buffer solution into the tumor in 10 animals. Immunohistochemical studies after stereotactic injection of rHuTNF-alpha showed total disappearance of the substance after 24 hours without internalization into tumor cells. Stereotactic injection of 7.3 micrograms rHuTNF 10 microliters into normal brain resulted in marked inflammatory response around the injection track, including microvascular thrombosis. These results demonstrate that rHuTNF has neither direct nor indirect cytotoxic activity on RG-2 glioma cells. Furthermore, before clinical use of rHuTNF-alpha in malignant gliomas, the authors suggest that receptor studies be done in each patient. In receptor-positive patients undergoing treatment with rHuTNF-alpha, precautions should be taken to prevent local encephalitic reactions.


J Neurosurg


Journal of neurosurgery


Kiwit JC,Schmitz KH,Daum L,Reifenberger G,Roosen N




Has Abstract


1991-10-01 00:00:00












  • Endoscope-assisted retrosigmoid infralabyrinthine approach to jugular foramen tumors.

    abstract:OBJECTIVE:Removal of jugular foramen (JF) tumors usually requires extensive skull base approaches and is frequently associated with postoperative morbidities such as lower cranial nerve injury. The endoscope-assisted retrosigmoid infralabyrinthine approach is a relatively new approach to tumors extending into the bony ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Samii M,Alimohamadi M,Gerganov V

    更新日期:2016-04-01 00:00:00

  • Surgical approaches for the lateral mesencephalic sulcus.

    abstract:OBJECTIVE:The brainstem is a compact, delicate structure. The surgeon must have good anatomical knowledge of the safe entry points to safely resect intrinsic lesions. Lesions located at the lateral midbrain surface are better approached through the lateral mesencephalic sulcus (LMS). The goal of this study was to compa...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Cavalcanti DD,Morais BA,Figueiredo EG,Spetzler RF,Preul MC

    更新日期:2019-04-12 00:00:00

  • Ventriculo-ureteral shunt insertion using percutaneous nephrostomy: a novel minimally invasive option in a patient with chronic hydrocephalus complicated by multiple distal ventriculoperitoneal shunt failures.

    abstract::The management of ventriculoperitoneal (VP) shunt failure is a common problem in neurosurgical practice. On occasion, extraperitoneal sites for CSF diversion are required when shunting to the peritoneal cavity has failed after multiple attempts. The authors report a novel minimally invasive procedure allowing cannulat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Pillai A,Mathew G,Nachimuthu S,Kalavampara SV

    更新日期:2017-03-17 00:00:00

  • Growth rate of secondary hydatid cysts of the brain. Case report.

    abstract::Bilateral intracerebral hydatid cysts developed in a 14-year-old patient after an infarct of presumed embolic origin in the left frontotemporoparietal region. The average rate of growth of these cysts was about 5 cm per year. This suggests that the growth rate is far from uniform and indeed, particularly in young pati...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Sierra J,Oviedo J,Berthier M,Leiguarda R

    更新日期:1985-05-01 00:00:00

  • Low flow velocity in the middle cerebral artery predicting infarction after bypass surgery in adult moyamoya disease.

    abstract::OBJECTIVE Direct and indirect bypass surgeries are recognized as the most effective treatments for preventing further stroke in adults with moyamoya disease (MMD). However, the risk factors for postoperative infarction after bypass surgery for MMD are not well established. Therefore, the objective of this study was to...

    journal_title:Journal of neurosurgery

    pub_type: 评论,杂志文章


    authors: Cho H,Jo KI,Yu J,Yeon JY,Hong SC,Kim JS

    更新日期:2017-05-01 00:00:00

  • Long-term motor outcome analysis using a motor score composite following surgical brachial plexus repair.

    abstract:OBJECT:Due to the complex and variable nature of brachial plexus injury, outcome analysis can be cumbersome and imprecise. Many scales have been devised, but no single scale is used uniformly. Moreover, despite several studies in which the authors have reported brachial plexus surgical data, no highly predictive clinic...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Ashley WW Jr,Baty JD,Hollander T,Noetzel MJ,Park TS

    更新日期:2007-04-01 00:00:00

  • Gamma knife radiosurgery for trigeminal neuralgia associated with multiple sclerosis.

    abstract:OBJECT:The authors assessed the efficacy and complications from gamma knife radiosurgery (GKS) for multiple sclerosis (MS)-associated trigeminal neuralgia (TN). METHODS:There were 15 patients with MS-associated TN (MS-TN). Treatment involved three sequential protocols, 70 to 90-Gy maximum dose, using a single 4-mm iso...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章


    authors: Rogers CL,Shetter AG,Ponce FA,Fiedler JA,Smith KA,Speiser BL

    更新日期:2002-12-01 00:00:00

  • Early immunological defects in comatose patients after acute brain injury.

    abstract:OBJECT:The aim of this prospective study was to evaluate the phagocytic, humoral, and cellular arms of the immune system in comatose patients shortly after severe brain injury and to compare the findings with those reported earlier in patients in a persistent vegetative state. The study was conducted in intensive care ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Wolach B,Sazbon L,Gavrieli R,Broda A,Schlesinger M

    更新日期:2001-05-01 00:00:00

  • Clinical evaluation of flat-panel detector compared with multislice computed tomography in 65 patients with acute intracranial hemorrhage: initial results. Clinical article.

    abstract:OBJECT:The goal in this study was to compare flat-panel detector (FD) CT with multislice (MS) CT in the visualization of intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), intraventricular hemorrhage, and external ventricular drains (EVDs) to evaluate the diagnostic quality and limitations of the new FD CT ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Struffert T,Eyupoglu IY,Huttner HB,Engelhorn T,Doelken M,Saake M,Ganslandt O,Doerfler A

    更新日期:2010-10-01 00:00:00

  • Intradural extramedullary tuberculoma of the cervical spine. Case report.

    abstract::A case is reported of a 45-year-old man who developed quadriplegia following a trivial motor-vehicle accident. Investigation including computerized tomography (CT) of the cervical spine revealed a large calcified lesion displacing the spinal cord and nerve roots, which proved to be a tuberculoma. The case is unusual i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Compton JS,Dorsch NW

    更新日期:1984-01-01 00:00:00

  • Use of a wedged microcatheter for curative transarterial embolization of complex intracranial dural arteriovenous fistulas: indications, endovascular technique, and outcome in 21 patients.

    abstract:OBJECT:The aim of this study was to describe the application of a novel transarterial approach to curative embolization of complex intracranial dural arteriovenous fistulas (DAVFs). This technique is particularly useful in patients harboring high-grade DAVFs with direct cortical venous drainage or for whom transvenous ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Nelson PK,Russell SM,Woo HH,Alastra AJ,Vidovich DV

    更新日期:2003-03-01 00:00:00

  • The pineal gland: anatomy, physiology, and clinical significance.

    abstract::Since the discovery of melatonin approximately 25 years ago, there has been intense study regarding the details of the structure and function of the pineal gland. This work is reviewed, with particular emphasis on those aspects of importance to human physiology and disease. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Erlich SS,Apuzzo ML

    更新日期:1985-09-01 00:00:00

  • Pathogens and glioma: a history of unexpected discoveries ushering in novel therapy.

    abstract::In the late 19th century, Dr. William B. Coley introduced the theory that infections may aid in the treatment of malignancy. With the creation of Coley's toxin, reports of remission during viral illnesses for systemic malignancies soon emerged. A few decades after this initial discovery, Austrian physicians performed ...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章,评审


    authors: Shah AH,Jusué-Torres I,Ivan ME,Komotar RJ,Kasahara N

    更新日期:2018-04-01 00:00:00

  • Neurosurgical implications of mannitol accumulation within a meningioma and its peritumoral region demonstrated by magnetic resonance spectroscopy: case report.

    abstract::Mannitol is widely considered the hyperosmolar therapy of choice in routine neurosurgical practice for the reduction of intracranial pressure (ICP). The authors present a unique case of a patient with a large meningioma treated with mannitol, in which mannitol accumulation within the tumor and its surrounding parenchy...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Sankar T,Assina R,Karis JP,Theodore N,Preul MC

    更新日期:2008-05-01 00:00:00

  • Dorsal root entry zone localization using direct spinal cord stimulation: an experimental study.

    abstract::Direct spinal cord stimulation and recording was performed in five dogs to identify the dorsal root entry zone (DREZ) and long tracts within the dorsal and dorsolateral spinal cord using electrophysiological mapping techniques. Intrathecal recordings were obtained from sites distal to the site of stimulation. Conducti...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Fazl M,Houlden DA

    更新日期:1995-04-01 00:00:00

  • Comparison of spinal cord gray matter and white matter softness: measurement by pipette aspiration method.

    abstract:OBJECT:Although the gray matter of the spinal cord has been thought to be softer than the white matter, there is no evidence to support this belief. Because the spinal cord is extremely soft, it has been difficult to measure the mechanical properties of the gray and white matter. The modulis of elasticity of the gray a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Ozawa H,Matsumoto T,Ohashi T,Sato M,Kokubun S

    更新日期:2001-10-01 00:00:00

  • A morphometric survey of the parasellar region in more than 2700 skulls: emphasis on the middle clinoid process variants and implications in endoscopic and microsurgical approaches.

    abstract::OBJECTIVE The middle clinoid process (MCP) is a bony projection that extends from the sphenoid bone near the lateral margin of the sella turcica. The varied prevalence and morphological features of the MCP in populations stratified by age, race, and sex are unknown; however, the knowledge of its anatomy and preoperati...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Sharma A,Rieth GE,Tanenbaum JE,Williams JS,Ota N,Chakravarthi S,Manjila S,Kassam A,Yapicilar B

    更新日期:2018-07-01 00:00:00

  • Extraaxial primitive neuroectodermal tumor mimicking a vestibular schwannoma: diagnostic and therapeutic difficulties. Report of two cases.

    abstract::Extraaxial cerebellopontine angle (CPA) medulloblastomas and other primitive neuroectodermal tumors (PNETs) are rare tumors. The authors report on two patients with PNETs who presented with progressive audiovestibular symptoms. In each case magnetic resonance (MR) imaging revealed an extraaxial lesion that filled the ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Kalamarides M,Dewolf E,Couvelard A,Shahidi A,Bouccara D,Cyna-Gorse F,Rey A,Sterkers O

    更新日期:2001-04-01 00:00:00

  • Maduromycosis of the brain. Case report.

    abstract::A rare case of a gas-containing brain abscess due to verified maduromycosis is described. Blackish material over the abscess cavity revealed the fungal elements. The pus from the abscess contained Streptococcus hemolyticus and Klebsiella organisms. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Natarajan M,Balakrishnan D,Muthu AK,Arumugham K

    更新日期:1975-02-01 00:00:00

  • Malignant triton tumor of the acoustic nerve. Case report.

    abstract::The authors present the clinical, radiological, pathological features, and autopsy findings of a patient with malignant triton tumor of the acoustic nerve, which probably arose from a pre-existing acoustic schwannoma. The term "malignant triton tumor" is applied to malignant schwannomas with rhabdomyoblastic different...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Han DH,Kim DG,Chi JG,Park SH,Jung HW,Kim YG

    更新日期:1992-05-01 00:00:00

  • Encoding of speed and direction of movement in the human supplementary motor area.

    abstract:OBJECT:The supplementary motor area (SMA) plays an important role in planning, initiation, and execution of motor acts. Patients with SMA lesions are impaired in various kinematic parameters, such as velocity and duration of movement. However, the relationships between neuronal activity and these parameters in the huma...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tankus A,Yeshurun Y,Flash T,Fried I

    更新日期:2009-06-01 00:00:00

  • Early diffusion-weighted MRI lesions after treatment of unruptured intracranial aneurysms: a prospective study.

    abstract::OBJECTIVE Diffusion-weighted MRI was used to assess periprocedural lesion load after repair of unruptured intracranial aneurysms (UIA) by microsurgical clipping (MC) and endovascular coiling (EC). METHODS Patients with UIA were assigned to undergo MC or EC according to interdisciplinary consensus and underwent diffusi...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章


    authors: Platz J,Wagner M,Güresir E,You SJ,Konczalla J,de Rochemont RD,Berkefeld J,Seifert V

    更新日期:2017-04-01 00:00:00

  • Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: relationships and prognostic value.

    abstract::Consecutive paraffin sections of 105 astrocytomas and 15 oligoastrocytomas were examined for expression of p53, MIB-1 (Ki-67), and proliferating cell nuclear antigen (PCNA). The tumors had been examined previously for genetic abnormalities and by flow cytometry. Regardless of the tumor's stage and grade and the patien...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Cunningham JM,Kimmel DW,Scheithauer BW,O'Fallon JR,Novotny PJ,Jenkins RB

    更新日期:1997-01-01 00:00:00

  • The sympathetic nervous system and atherosclerosis.

    abstract::Morphometric and chemical changes in the arterial wall were studied after 12 months of diet-induced atherosclerosis in rhesus monkeys treated with either bilateral surgical thoracic sympathectomy or propranolol. There was a marked reduction in the progression of atherosclerosis in the carotid arteries and a moderate r...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Lichtor T,Davis HR,Johns L,Vesselinovitch D,Wissler RW,Mullan S

    更新日期:1987-12-01 00:00:00

  • Regional cerebral ischemia by occlusion of the posterior communicating artery and the middle cerebral artery in gerbils.

    abstract::The authors have created an experimental model of regional cerebral ischemia in gerbils that is reproducible and has a low mortality rate. In gerbils, either the posterior communicating artery (PCoA) or the middle cerebral artery (MCA) was occluded, and the distribution of cerebral ischemia from each surgical procedur...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Yoshimine T,Yanagihara T

    更新日期:1983-03-01 00:00:00

  • Neurenteric cysts in children: 16 consecutive cases and review of the literature.

    abstract:OBJECT:The authors of this retrospective review and analysis of the literature cover an institutional series of neurenteric cysts of the central nervous system in children treated in the magnetic resonance imaging era during a 14-year period. METHODS:Sixteen patients 20 days to 14 years of age are described. The most ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: de Oliveira RS,Cinalli G,Roujeau T,Sainte-Rose C,Pierre-Kahn A,Zerah M

    更新日期:2005-12-01 00:00:00

  • Effect of the novel high-affinity glycine-site N-methyl-D-aspartate antagonist ACEA-1021 on 125I-MK-801 binding after subdural hematoma in the rat: an in vivo autoradiographic study.

    abstract::Acute subdural hematoma (SDH) complicates 20% of severe human head injuries and causes death or severe disability in 60% of these cases, due to brain swelling and high intracranial pressure. Although the mechanisms for these phenomena are unknown, previous studies have implicated excitatory amino acid-mediated mechani...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Di X,Bullock R

    更新日期:1996-10-01 00:00:00

  • Risk of early closed reduction in cervical spine subluxation injuries.

    abstract:OBJECT:The authors retrospectively reviewed 121 patients with traumatic cervical spine injuries to determine the risk of neurological deterioration following early closed reduction. METHODS:After excluding minor fractures and injuries without subluxation, the medical records and imaging studies (computerized tomograph...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Grant GA,Mirza SK,Chapman JR,Winn HR,Newell DW,Jones DT,Grady MS

    更新日期:1999-01-01 00:00:00

  • Spontaneous regression of a cerebral arteriovenous malformation in a child with hereditary hemorrhagic telangiectasia. Case report.

    abstract::Patients with hereditary hemorrhagic telangiectasia (HHT) are at risk for the development of cerebral arteriovenous malformations (AVMs). The authors report a case of a spontaneously regressing cerebral AVM in a patient with HHT. The lesion was diagnosed on the basis of findings on screening magnetic resonance imaging...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Leung KM,Agid R,terBrugge K

    更新日期:2006-11-01 00:00:00

  • Bow hunter stroke caused by cervical disc herniation. Case report.

    abstract::Bow hunter stroke, which is characterized by transient vertebrobasilar ischemia brought on by head turning, is an unusual condition usually caused by structural abnormalities at the craniocervical junction. The authors present a case in which compression of the left vertebral artery (VA) at the C4-5 level was caused b...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Vates GE,Wang KC,Bonovich D,Dowd CF,Lawton MT

    更新日期:2002-01-01 00:00:00