Analysis of pemoline in serum by high performance liquid chromatography: clinical application to optimize treatment of hyperactive children.

abstract：:Oral posaconazole (PSZ), an azole antifungal drug, was recently introduced for the treatment of invasive fungal infections. The prescription of PSZ together with the immunosuppressant tacrolimus (TRL) was evaluated in 14 lung transplant patients with cystic fibrosis. PSZ inhibited CYP3A4 TRL metabolism, resulting in a...

journal_title：Therapeutic drug monitoring

authors： Berge M,Chevalier P,Benammar M,Guillemain R,Amrein C,Lefeuvre S,Boussaud V,Billaud EM

更新日期：2009-06-01 00:00:00

abstract：:The possible occurrence of a kinetic interaction between cyclosporine A and glibenclamide was assessed by reviewing data of six posttransplant diabetic patients who received the two drugs concurrently. Coadministration of the two drugs resulted in a 57% increase in the steady-state plasma cyclosporine levels despite n...

journal_title：Therapeutic drug monitoring

authors： Islam SI,Masuda QN,Bolaji OO,Shaheen FM,Sheikh IA

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Because of its superior sensitivity and specificity, multianalyte high-performance liquid chromatography coupled with tandem mass spectrometry has become the gold standard in clinical toxicology. Although several qualitative and quantitative liquid chromatography coupled with tandem mass spectrometry assays ...

journal_title：Therapeutic drug monitoring

authors： Klepacki J,Davari B,Boulet M,Lizarraga R,Christians U

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The anticonvulsant properties of phenytoin (PHT) were discovered in 1938. Since then, it has been one of the most widely used antiepileptic drugs. It is slowly absorbed, extensively plasma protein-bound, exhibits a nonlinear, concentration-dependent pharmacokinetic profile, and has a narrow therapeutic range...

journal_title：Therapeutic drug monitoring

authors： Aliwarga T,Cloyd JC,Goel V,Brundage RC,Marino SE,Leppik IE,Remmel RP

更新日期：2011-02-01 00:00:00

abstract：:Phenytoin is an effective anticonvulsant, but high serum phenytoin concentrations may be associated with serious toxicity. The upper limit for the therapeutic serum concentration of phenytoin is considered to be 80 micromol/L. However, in some situations higher serum concentrations are needed to control seizures. The ...

journal_title：Therapeutic drug monitoring

authors： Kozer E,Parvez S,Minassian BA,Kobayashi J,Verjee Z,Koren G

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Analysis of residual gene expression of the nuclear factor of activated T cell (NFAT)-regulated genes has been developed as a pharmacodynamic biomarker to monitor therapy with calcineurin inhibitors. The availability of commercial primer sets (Search-LC) and the well-established assay protocol makes this bio...

journal_title：Therapeutic drug monitoring

authors： Abdel-Kahaar E,Giese T,Sommerer C,Rieger H,Shipkova M,Wieland E

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Thiopurine S-methyltransferase (TPMT) is an excellent example of an enzyme whose pharmacogenetic polymorphisms affect efficacy and toxicity of a drug. The association between TPMT activity and thiopurine-related myelosuppression is well recognized. To study the significance of TPMT deficiency in thiopurine m...

journal_title：Therapeutic drug monitoring

authors： Misdaq M,Andag R,Oellerich M,Asif AR,von Ahsen N

更新日期：2012-10-01 00:00:00

abstract：:Central venous access catheters are commonly used in clinical oncology. The double lumen variant is applied in pharmacokinetic studies for simultaneous administration and blood sampling when frequent blood collections are necessary. Occlusion of one lumen, a common complication, necessitates the investigator perform b...

journal_title：Therapeutic drug monitoring

authors： de Jonge ME,Mathôt RA,van Dam SM,Rodenhuis S,Beijnen JH

更新日期：2003-06-01 00:00:00

abstract：:Characterization of antibiotic pharmacokinetics in patients with renal insufficiency may be complicated by interfering substances within the assay. We compared three different assays for teicoplanin in serum and dialysate of 10 hemodialysis and six continuous ambulatory peritoneal dialysis (CAPD) patients. The microbi...

journal_title：Therapeutic drug monitoring

authors： Awni WM,St Peter WL,Guay DR,Kenny MT,Matzke GR

更新日期：1991-11-01 00:00:00

abstract：:Iron overload resulting from transfusion dependency in some patients with chronic anaemia can be prevented by chelation. Deferasirox is an oral alternative to the well studied but inconvenient deferroxamine therapy. The pharmacokinetic parameters of this new drug suggest potential interindividual variability and patie...

journal_title：Therapeutic drug monitoring

authors： Chauzit E,Bouchet S,Micheau M,Mahon FX,Moore N,Titier K,Molimard M

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:We report a feasibility study based on our large-scale experience with mycophenolate mofetil dose adjustment based on mycophenolic acid interdose area under the curve (AUC) in renal transplant patients. METHODS:Between 2005 and 2010, 13,930 requests for 7090 different patients (outside any clinical trial) w...

journal_title：Therapeutic drug monitoring

authors： Saint-Marcoux F,Vandierdonck S,Prémaud A,Debord J,Rousseau A,Marquet P

更新日期：2011-06-01 00:00:00

abstract：:There are a number of effective but highly toxic drugs that exhibit a narrow therapeutic index and marked interpatient pharmacokinetic variability. Individualized therapy with such drugs requires therapeutic drug monitoring (TDM) to obtain the desired clinical effects safely. Cost-effectiveness analysis in health care...

journal_title：Therapeutic drug monitoring

authors： Touw DJ,Neef C,Thomson AH,Vinks AA,Cost-Effectiveness of Therapeutic Drug Monitoring Committee of the International Association for Therapeutic Drug Monitoring and Clinical Toxicology.

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Non-vitamin K antagonist oral anticoagulants (NOACs) are approved for several indications for prophylaxis of thromboembolism at fixed oral doses. The analysis of NOAC activity/concentration may be required in special patient populations. Heptest coagulation assay determines both factor Xa and thrombin inhibi...

journal_title：Therapeutic drug monitoring

authors： Du S,Harenberg J,Krämer S,Krämer R,Wehling M,Weiss C

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Beta-lactams are first-line antibiotics for the management of superficial infections due to burn injury. There is sparse data available on therapeutic drug monitoring (TDM) in patients with burns in a ward setting. This study was conducted to evaluate the utility of a beta-lactam TDM program in a cohort of b...

journal_title：Therapeutic drug monitoring

authors： Patel BM,Paratz J,See NC,Muller MJ,Rudd M,Paterson D,Briscoe SE,Ungerer J,McWhinney BC,Lipman J,Roberts JA

更新日期：2012-04-01 00:00:00

abstract：:Assessment of renal function and relating this parameter to amino-glycoside clearance is important for an appropriate individualization of dosage regimens in patients with impaired renal function. However, it has been suggested that in cystic fibrosis (CF), creatinine clearance (CrCl) is not a good predictor of tobram...

journal_title：Therapeutic drug monitoring

authors： Town DJ,Vinks AA,Jacobs F,Heijerman HG,Bakker W

更新日期：1996-10-01 00:00:00

abstract：:The authors describe a reverse-phase high-performance liquid chromatography-electrospray-tandem mass spectrometry method for the measurement of nicotine in human plasma. Samples (500 microL) with added deuterium-labeled d3-nicotine as an internal standard (IS) were treated with a 2-step process of ether extraction (6 ...

journal_title：Therapeutic drug monitoring

authors： Taylor PJ,Forrest KK,Landsberg PG,Mitchell C,Pillans PI

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Hydroxychloroquine (HCQ) is an effective treatment for patients with cutaneous lupus erythematosus (CLE) or systemic lupus erythematosus (SLE) and has been used for these patients in more than 70 nations. However, in Japan, HCQ has not been approved for CLE or SLE. To establish an appropriate therapeutic reg...

journal_title：Therapeutic drug monitoring

authors： Morita S,Takahashi T,Yoshida Y,Yokota N

更新日期：2016-04-01 00:00:00

abstract：:Caffeine is a potentially useful alternative to theophylline for the treatment and prevention of apnea of prematurity because of its lower toxicity and longer terminal half-life. Monitoring of salivary caffeine concentrations is less invasive than blood sampling, especially in very sick premature neonates. Caffeine ci...

journal_title：Therapeutic drug monitoring

authors： Lee TC,Charles BG,Steer PA,Flenady VJ

更新日期：1996-06-01 00:00:00

abstract：:Four different immunoassays were used to measure cyclosporine A (CsA) plasma (20 degrees C) levels in heart and kidney transplant recipients. Two radioimmunoassays (RIAs) (Sandimmune and Cyclotrac) and the fluorescence polarization immunoassay (FPIA) were based on polyclonal antibodies, whereas the fourth (Cyclotrac-S...

journal_title：Therapeutic drug monitoring

authors： Hesse CJ,Baan CC,Daane R,Stolk BJ,Jutte NH,Hendriks GF,Weimar W

更新日期：1990-11-01 00:00:00

abstract：:A rapid and simple procedure based on gas chromatography-mass spectrometry (GC-MS) is described for determination of Delta-tetrahydrocannabinol (THC), 11-hydroxy-Delta-tetrahydrocannabinol (THC-OH) and 11-nor-Delta-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in meconium using Delta-tetrahydrocannabinol (Delta-TH...

journal_title：Therapeutic drug monitoring

authors： Marchei E,Pellegrini M,Pacifici R,Palmi I,Lozano J,García-Algar O,Pichini S

更新日期：2006-10-01 00:00:00

abstract：:Digoxin and gentamicin are widely used in pediatric medicine, and therapeutic monitoring is mandatory because of their narrow margin of safety and wide interpatient and intrapatient pharmacokinetic variabilities. Saliva sampling may be of potential interest, especially in children, in whom blood sampling is often diff...

journal_title：Therapeutic drug monitoring

authors： Berkovitch M,Bistritzer T,Aladjem M,Burtin P,Dagan T,Chen-Levi Z,Freedom R,Koren G

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Cyclosporine A (CsA) is used as a posttransplantation immunosuppressant drug, and careful monitoring of CsA concentration in whole blood is essential. A new automated electrochemiluminescence immunoassay (ECLIA) for CsA measurement has been assessed in a multicenter evaluation. METHODS:Residual EDTA whole b...

journal_title：Therapeutic drug monitoring

authors： Vogeser M,Shipkova M,Rigo-Bonnin R,Wallemacq P,Orth M,Widmann M,Verstraete AG

更新日期：2014-10-01 00:00:00

abstract：:Designer drugs of the methylenedioxyphenylalkylamine type are increasingly abused. Studies on their metabolism in humans are necessary to develop a reliable gas chromatography--mass spectrometry (GC-MS) screening procedure. Such a method must allow their detection in urine for drug testing in clinical and forensic tox...

journal_title：Therapeutic drug monitoring

authors： Maurer HH

更新日期：1996-08-01 00:00:00

abstract：:A stabilized therapeutic drug monitoring procedure incorporating the novel Empore solid-phase extraction membrane (SPEM) for isolation of the antiarrhythmic drugs mexiletine (MEX) and flecainide (FLEC) from serum is described. Routinely, serum (0.5 ml), adjusted to pH 4.5, is passed through an octyl (C8) SPEM to extra...

journal_title：Therapeutic drug monitoring

authors： Lensmeyer GL,Wiebe DA,Doran TC

更新日期：1992-10-01 00:00:00

abstract：PURPOSE:Substance use disorder often coexists with other psychiatric disorders, resulting in the simultaneous use of recreational and prescription drugs. The authors aimed to identify potential pharmacokinetic and pharmacodynamic interactions between new psychoactive substances of the cathinone class and specific presc...

journal_title：Therapeutic drug monitoring

authors： Contrucci RR,Brunt TM,Inan F,Franssen EJF,Hondebrink L

更新日期：2020-02-01 00:00:00

abstract：:In a prospective study over 6 months, the relationship between serum lipid parameters and CsA whole blood trough concentrations was investigated in 39 renal transplant recipients receiving a triple immunosuppressive therapy with cyclosporin (CsA), azathioprine and prednisone. CsA trough concentrations were measured wi...

journal_title：Therapeutic drug monitoring

authors： von Ahsen N,Helmhold M,Schütz E,Eisenhauer T,Armstrong VW,Oellerich M

更新日期：1997-04-01 00:00:00

abstract：:Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine (m-CPP) were studied in six depressed patients treated with trazodone. The daily dose of trazodone was 150 mg in three cases and 300 mg in three cases. Carbamazepine, 400 mg/day, was coad...

journal_title：Therapeutic drug monitoring

authors： Otani K,Ishida M,Kaneko S,Mihara K,Ohkubo T,Osanai T,Sugawara K

更新日期：1996-04-01 00:00:00

abstract：:An analysis of pH-induced changes of drug binding may contribute to the understanding of the mechanisms involved and the clinical relevance. A literature search was performed, and acceptance criteria set up, to select reported data for quantitative evaluation. The relationship between percentage of unbound drug, fu, a...

journal_title：Therapeutic drug monitoring

authors： Hinderling PH,Hartmann D

更新日期：2005-02-01 00:00:00

abstract：:In this report we describe a rapid and sensitive micromethod using high performance liquid chromatography (HPLC) with electrochemical detection (ED) to measure morphine concentration in serum or plasma. The separation of morphine and the internal standard 5-hydroxyquinoline, from interfering compounds present in plasm...

journal_title：Therapeutic drug monitoring

authors： Vandenberghe H,MacLeod SM,Chinyanga H,Soldin SJ

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:The International Interlaboratory Quality Control PROGRAM for Therapeutic Drug Monitoring of Antiretroviral Drugs in Human Plasma/Serum was initiated in 1999. We have previously published our experience during the first 10 years of the PROGRAM. Since 2010, 3 newly developed antiretroviral agents have been ad...

journal_title：Therapeutic drug monitoring

authors： Burger D,Krens S,Robijns K,Aarnoutse R,Brüggemann R,Touw D

更新日期：2014-12-01 00:00:00