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Three-dimensional folding of Tetrahymena thermophila rRNA IVS sequence: a proposal.

Abstract：

:We studied the Tetrahymena thermophila rRNA IVS sequence with the aim of obtaining a model of the structure characterized by the bases proximity of the self-reactions sites. The considered sequence kept up those fragments essential for its catalytic activity as demonstrated by deletion mutants. The first step was the theoretical analysis with a computer method previously proposed, to find optimal free energy secondary structures with the required features, under the suitable constrains. Then we tried folding the obtained secondary structures, in low resolution tertiary models, which kept up the proximity of the catalytic sites also in the space. The proposed tertiary folding seems to provide for a better explanation to the transesterification mechanisms and moreover it is in good agreement with the experimental data (activity of mutants, enzymatic cleavages, phylogenetically conserved regions).

journal_name

J Biomol Struct Dyn

journal_title

Journal of biomolecular structure & dynamics

authors

Benedetti G,Morosetti S

doi

10.1080/07391102.1991.10507864

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

1045-55

issue

5

eissn

0739-1102

issn

1538-0254

journal_volume

8

pub_type

杂志文章

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