Abstract:
:In a retrospective, non-random study, the effect of supplementary medical treatment (Dexamethasone, barbiturates) was investigated upon the prognosis of severe head injuries. Of 107 children and adolescents up to 16 years of age, 51 were treated with Dexamethasone; 56 received only standard therapy. Evaluation of the results shows that Dexamethasone therapy in high doses clearly reduced mortality in cases of severe head injuries (from 33.3% to 13.6%) without causing any noteworthy neurological defects. Among the individual types of injury, the effect was most evident in cases of intracranial hematoma (drop in mortality from 36.8% to 11.8%). On the other hand, definitive effects of therapy could not be established in the most severely injured patients with extreme brain damage and those with milder forms of trauma without substantial cerebral edema. Barbiturates were given only when severe intracranial pressure could not be alleviated by other means. Remission was successful in a few cases but the total number is not yet sufficient for a conclusive evaluation. Further important factors for prognosis are: depth and length of the initial disturbance of consciousness, age, concomitant injuries as well as some peculiarities of childhood and adolescence (tendency to develop severe cerebral edemas, clustering of atypical intracranial hematomas).
journal_name
Neuropediatricsjournal_title
Neuropediatricsauthors
Kretschmer Hdoi
10.1055/s-2008-1059574subject
Has Abstractpub_date
1983-08-01 00:00:00pages
176-81issue
3eissn
0174-304Xissn
1439-1899journal_volume
14pub_type
杂志文章相关文献
NEUROPEDIATRICS文献大全abstract:BACKGROUND:Advanced modalities such as functional magnetic resonance imaging (MRI) and diffusion MR tractography offer in vivo information about brain networks and are therefore increasingly used for neurosurgical planning in children also. AIM:This study aims to study the application of routine and advanced tractogra...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0034-1395346
更新日期:2015-02-01 00:00:00
abstract::Two children with acute transverse myelopathy following adenovirus and Borrelia Burgdorferi infections are presented. The diagnosis stems from the clinical presentation, the determination of specific antibodies in serum and the favorable response to penicillin treatment in the case of neuroborreliosis. Both children m...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071427
更新日期:1991-05-01 00:00:00
abstract::Rett syndrome affects young girls. The molecular basis is mysterious. One tenable hypothesis can be that the programmed early infantile death of neuronal cells is reprogrammed. The bcl-2 gene on chromosome 22 has been shown to play a role in the apoptosis process. No sequence abnormalities were detected in the bcl-2 g...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1073047
更新日期:1994-12-01 00:00:00
abstract::18F fluorodeoxyglucose (18FDG) and positron tomography (PT) were used in 20 full term babies with seizures or hypotonia to describe regional cerebral glucose metabolism. Among babies with seizures, birth asphyxia was the most common cause. PT was performed at age 6-17 days. One hour before PT, 18FDG (50-100 microCi/kg...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1052419
更新日期:1988-08-01 00:00:00
abstract::In order to determine the relationship between visual functions and neonatal cerebral ultrasound, neurological examinations and cognitive development, a prospective longitudinal study was conducted in 69 high-risk very-low-birthweight children. Visual development was studied at 1 and 2.6 years of corrected age by asse...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071533
更新日期:1993-06-01 00:00:00
abstract::Between 1970 and 1986, 120 children with central nervous system malignancy were treated with radiation therapy. These included 44 low-grade astrocytomas, 11 high grade astrocytomas, 32 medulloblastomas, 15 ependymomas/ependymoblastomas, 3 primitive neuroectodermal tumors and 8 pineal tumors. Seven children were treate...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071348
更新日期:1992-10-01 00:00:00
abstract::We report a nine-year-old boy with the features of Leigh syndrome (LS) and a severe cytochrome-c oxidase (COX) deficiency with a single thymidine insertion at nucleotide position 5537 (T 5537i) in the tRNA Trp gene of mitochondrial DNA. During infancy the boy was irritable and hypotonus was noticed. Early motor develo...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2003-39607
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:To investigate the association between blood mercury level and attention-deficit hyperactivity disorder (ADHD) in Chinese children in Hong Kong. METHODS:Fifty-two children with ADHD aged below 18 years diagnosed by DSM IV criteria without perinatal brain insults, mental retardation or neurological deficits w...
journal_title:Neuropediatrics
pub_type: 杂志文章,收录出版
doi:10.1055/s-2006-924577
更新日期:2006-08-01 00:00:00
abstract::Fibromuscular dysplasia is a segmental, nonatheromatous angiopathy. A 13-year-old patient is reported with stroke. Left-sided carotid angiogram revealed typical findings of fibromuscular dysplasia in the left carotid artery. ...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071288
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:Glutaryl-CoA dehydrogenase deficiency (GDD) is a recessively inherited neurometabolic disorder associated with encephalopathic crises and severe extrapyramidal symptoms. Treatment regimens including glucose and electrolyte infusions during acute illnesses, oral carnitine supplementation and/or a low-protein ...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-973761
更新日期:1996-06-01 00:00:00
abstract::A newborn with a rare type of lissencephaly is reported, characterized by extreme cerebral and cerebellar hypoplasia. The diagnosis was made by postmortem magnetic resonance imaging, indicating the value of such studies to evaluate neuronal migration disorders in patients in whom autopsy cannot be performed. Two earli...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2007-973778
更新日期:1996-10-01 00:00:00
abstract::Careful clinical delineation and advances in analytical methods have opened new possibilities for the detection of inherited neurometabolic disorders, some of which require specific CSF analyses for diagnosis. Although patients suffering from these disorders have recognizable phenotypes, there are strong indications t...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-2007-973538
更新日期:1998-04-01 00:00:00
abstract::The diagnosis of mitochondrial respiratory chain deficiency is usually made by analysis of mitochondrial respiratory chain activity in muscle biopsy. We describe 4 patients in whom the diagnosis was based on mitochondrial respiratory chain deficiency in liver alone. In 3 patients, liver complex IV activity was deficie...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2005-865866
更新日期:2005-08-01 00:00:00
abstract::We report the occurrence of subacute sclerosing panencephalitis (SSPE) in two brothers two years after measles infection. The diagnosis was confirmed by compatible data from medical history, occurrence of autochthonic measles virus (MV) IgG production in the central nervous system (CNS), and pathognomonic EEG changes....
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2003-44672
更新日期:2003-12-01 00:00:00
abstract::Autosomal recessive microcephaly has long been recognized in association with normal early motor development and mild to severe mental retardation. We report three sibling pairs with microcephaly and severe neurological impairment. These cases and other sibling pairs reported in the literature illustrate that microcep...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1071313
更新日期:1992-02-01 00:00:00
abstract::The definition and the clinical picture of arthrogryposis multiplex congenita (AMC) are discussed and the associated anomalies, deformities and syndromes are listed. It is stressed that isolated congenital contractures in (progressive) neuromuscular disorders may be manifestations of AMC, dependent on the moment of th...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1059546
更新日期:1983-02-01 00:00:00
abstract::24 healthy full-term newborns underwent polygraphic recordings of EEG, EMG, EOG, ECG, abdominal and thoracic respiration during day-time-sleep. Transient EEG patterns (rhythmic alpha and beta activity, spikes/sharp waves and frontal sharp transients) were visually evaluated and quantified. Rhythmic alpha activity is n...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1059609
更新日期:1982-08-01 00:00:00
abstract::The authors report a family in whom three members suffered from congenital hydrocephalus and ocular abnormalities. One of these patients showed along with these symptoms congenital muscular dystrophy. In this child, autopsy disclosed severe cerebral malformations consisting of lissencephaly, arhinencephaly, stenosis o...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1052531
更新日期:1986-11-01 00:00:00
abstract::Dravet syndrome presents with generalized and unilateral clonic or clonic-tonic seizures that occur during the first year of life, followed by severe epilepsy. Prolonged seizures are often provoked by fever and usually followed by recovery of the previous condition. We describe the case of a 13-month-old girl with Dra...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0032-1327772
更新日期:2013-06-01 00:00:00
abstract::Four cases of periventricular ischemia without hemorrhage in premature infants are described in which positive rolandic sharp waves (PRSW) were predominant in the electroencephalogram (EEG). These findings suggest the relationship of PRSW to periventricular ischemia rather than to intraventricular hemorrhage, per se, ...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1052529
更新日期:1986-11-01 00:00:00
abstract::We report on 12 children with neuronal ceroid lipofuscinosis (NCL) diagnosed between 1974-1995 in the West of Scotland. Diagnosis was made on the basis of clinical, electrophysiological, radiological and pathological examination including electron microscopy (EM) in all cases. Incidence was calculated on the basis of ...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-2007-973690
更新日期:1997-06-01 00:00:00
abstract::Primary degeneration of the granular layer of the cerebellum is an autosomal recessive disorder exhibiting characteristic clinical features: hypotonia, strabismus, delayed motor development, nonprogressive ataxia, delayed language development with dysarthria and mental retardation. We studied fourteen children, seven ...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1073020
更新日期:1994-08-01 00:00:00
abstract::Alternating hemiplegia of childhood (AHC) is a severe brain disorder, mainly characterised by episodes of hemiplegia, progressive mental retardation, and other severe paroxysmal and permanent neurological symptoms. Clinically and genetically, there is some overlap with sporadic (SHM) and familial (FHM) hemiplegic migr...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2006-924609
更新日期:2006-10-01 00:00:00
abstract::Observations of extreme unilateral widening of Virchow-Robin spaces (VRS) are rare and hitherto confined to adult, mainly old-aged patients. Magnetic resonance imaging (MRI) was performed in two unrelated boys aged 3 years with developmental coordination disorders. In one of these patients, follow-up MRI and diffusion...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0029-1246158
更新日期:2009-10-01 00:00:00
abstract::A 7-year-old boy suffering from X-linked hypogammaglobulinemia and progressive myoclonic encephalopathy is reported. The onset of neurological disturbances is at four years of age with ataxic gait and myoclonic jerks. The EEG shows a progressive slowing of background activity, bilateral diffuse and repetitive, pseudop...
journal_title:Neuropediatrics
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1071298
更新日期:1989-11-01 00:00:00
abstract::Brainstem auditory evoked potentials (BAEP) were studied in 93 newborns (49 preterm and 44 fullterm) admitted to the neonatal intensive care unit. One group of 42 infants (28-42 wk CA) were considered at low risk for perinatal complications and served to establish the normal ranges of the BAEP parameters (wave I peak ...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1052503
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:Hereditary spastic paraplegia is a neurodegenerative phenotype characterized by a progressive loss of corticospinal motor tract function. In a majority of affected individuals the pathogenesis remains undetermined. METHODS:We identified a series of patients with a phenotype of nonsyndromic spastic paraplegi...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0034-1389161
更新日期:2014-12-01 00:00:00
abstract::Seizures are the most common neurological emergency in the neonates, and this age group has the highest incidence of seizures compared with any other period of life. The author provides a narrative review of recent advances in the genetics of neonatal epilepsies, new neonatal seizure classification system, diagnostics...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-0040-1721702
更新日期:2020-12-08 00:00:00
abstract::Five patients with the clinical diagnosis of fetal alcohol syndrome (FAS) died at the ages of 8 and 4 months and 17, 4 and 2 days. Neuropathological examination revealed microencephalic brains in all cases, without morphological evidence of maturation delay. One of them showed agenesis of the corpus callosum and hypop...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1059578
更新日期:1983-11-01 00:00:00
abstract::The response of kidney and bone to parathyroid extract (PTE) was investigated in 8 epileptic children on long-term treatment with primidone in combination with phenytoin or other anticonvulsant drugs. The results indicate a dissociation between normal and cyclic AMP excretion and disturbed renal handling of phosphate ...
journal_title:Neuropediatrics
pub_type: 杂志文章
doi:10.1055/s-2008-1059588
更新日期:1982-02-01 00:00:00