Challenges and opportunities in abdominal aortic aneurysm research.

Abstract:

:Abdominal Aortic Aneurysms (AAAs) are associated with advanced age, male gender, cigarette smoking, atherosclerosis, hypertension, and genetic predisposition. Basic research studies have led to a better understanding of aneurysm disease over the past two decades. There has also been a growing appreciation that fundamental knowledge regarding the process of aneurysmal degeneration is still somewhat limited. Opportunities in research include: 1) the investigation of potential new mechanism-based pharmacologic interventions; 2) identify the genetic basis for an inherited predisposition; 3) develop and refine noninvasive approaches for the early detection; 4) examine potential novel surgical approaches and design new biomaterials; and 5) initiate and promote awareness programs for diagnosis and treatment of aortic aneurysms. The optimal approach to addressing these issues will require integrative, multidisciplinary research programs that involve basic scientists working in concert with vascular and cardiothoracic surgeons, as well as other clinical specialists with expertise in vascular disease.

journal_name

J Vasc Surg

authors

Wassef M,Upchurch GR Jr,Kuivaniemi H,Thompson RW,Tilson MD 3rd

doi

10.1016/j.jvs.2006.09.004

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

192-8

issue

1

eissn

0741-5214

issn

1097-6809

pii

S0741-5214(06)01628-4

journal_volume

45

pub_type

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