Abstract:
:Isoprenaline and forskolin both inhibit contractions induced by antigen or by the calcium ionophore A23187 of guinea pig tracheal spirals and parenchymal strips. Antigen-induced airway contraction is considerably more sensitive to the inhibitory effects of isoprenaline than is A23187-induced contraction. In contrast, forskolin is equiactive as an inhibitor of antigenic and ionophoric contractions. Forskolin is a more effective inhibitor of the prolonged phase of antigen-induced tracheal contraction than of the initial peak phase, which may suggest selectivity for the lipoxygenase pathway of arachidonic acid metabolism. Isoprenaline inhibits the mechanisms of the primary peak phase and of the prolonged phase equally. Although there were little, if any, differences between normal and sensitized tissues in the modulation of A23187-induced contractions of parenchyma, distinct differences were observed in trachea. Low concentrations (10(-8)-10(-7) M) of isoprenaline and forskolin enhanced A23187-induced contraction of sensitized, but not normal trachea. Higher concentrations were inhibitory. The results demonstrate that sensitization affects the modulation by isoprenaline and forskolin of A23187-induced contraction of guinea pig trachea.
journal_name
Can J Physiol Pharmacoljournal_title
Canadian journal of physiology and pharmacologyauthors
Burka JFdoi
10.1139/y83-089subject
Has Abstractpub_date
1983-06-01 00:00:00pages
581-9issue
6eissn
0008-4212issn
1205-7541journal_volume
61pub_type
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:1983-11-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:1983-11-01 00:00:00
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更新日期:1982-02-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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更新日期:1992-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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更新日期:1987-03-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y81-103
更新日期:1981-07-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:1984-10-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:2014-01-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y83-167
更新日期:1983-10-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:2009-03-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章,评审
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更新日期:1994-12-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y88-044
更新日期:1988-03-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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更新日期:1991-06-01 00:00:00