Abstract：
:Therapies targeted on cell signal pathways that control cell division and tumor angiogenesis have been developed over the last five years for non small cell lung cancer (NSCLC) with some amazing results, in subgroups of selected patients, predicting more significant success in the upcoming years. Compounds targeted on EGF tyrosine kinase receptor have been tested in large clinical phase 2 and 3 trials including thousands of patients. Their efficacy has been proved, in second and third line trials, after first line cisplatin-based chemotherapy for non-mucinous adenocarcinoma in non-smokers, women and Asian patients. Response rates vary from 10% in non selected Caucasian patients to 40% in non-smoking Asian patients with long survivals. Therapeutic targeting improves success rates, either relying on EGFR gene amplification detection by FISH, or search for EGFR tyrosine kinase domain mutations. Commercial kits are available for routine molecular diagnosis of domain mutations potentially enabling molecular targeting in addition to clinical targeting. Angiogenesis inhibitors, especially monoclonal antibody to VEGF, bevacizumab, have also been developed in the last few years. Bevacizumab associated with classical cytotoxic chemotherapy led, in selected patients (with non squamous cell lung cancer and no past history of cardiovascular disease) to an increase of median survival to more than 12 months with tolerable toxicity. Other drugs that have both anti-EGFR activity and anti-angiogenic properties will be soon developed, since future bioactive anti-cancer drugs will probably be multi-targeted drugs.
journal_name
Rev Pneumol Clinjournal_title
Revue de pneumologie cliniqueauthors
Zalcman G,Richard N,Bergot Edoi
10.1016/s0761-8417(07)90085-1subject
Has Abstractpub_date
2007-02-01 00:00:00pages
20-8issue
1eissn
0761-8417issn
1776-2561pii
MDOI-RPC-02-2007-63-1-0761-8417-101019-200520001journal_volume
63pub_type
杂志文章,评审abstract：INTRODUCTION:Intrapleural rupture of pulmonary hydatid cyst (PHC) is a rare but dangerous complication. The purpose of this study was to report the characteristics of this form of thoracic hydatidosis and analyze the favoring factors. MATERIALS AND METHODS:Between 1996 and 2011, 75 patients were operated in our depart...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2013.12.006
更新日期：2014-08-01 00:00:00
abstract：:Two cases of isolated pleural actinomycosis are reported. This form is much less frequent than the pulmonary form, and it accounts for only 20% of thoracic actinomycoses. The bacteriological diagnosis is easily obtainable by pleural puncture, provided it has not been obscured by previous antibiotic therapy and provide...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
abstract：:Since the advent of antituberculosis drugs, endobronchial tuberculosis has become an exceptional finding, often in a misleading context. Cases reported generally occur in patients with immune deficit. We report 21 cases of endobronchial tuberculosis in immunocompetent patients (mean age 37 years). Clinical and radiolo...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
abstract：:The various physiopathological components of asthmatic disease are interwoven. Experimental models used to study the sites of impact of an anti-asthmatic substance seek to separate the different mechanisms. The in vitro bronchial tissue model is rarely available in man. Progress is being made towards the development o...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1985-01-01 00:00:00
abstract：:The authors report a case of AIDS revealed by pleuropulmonary cryptococcosis. The infection was diagnosed by culture of the pleural fluid and confirmed by microscopic examination of the cerebrospinal fluid, using Indian ink as stain. Apyrexia and return to normal of chest radiography were obtained with oral fluconazol...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:The authors present a case of nephrotic syndrome due to focal-segmental glomerulosclerosis, occurring three years after thymectomy and myasthenia gravis. Twenty-three other cases of nephrotic syndrome associated with thymoma and myasthenia gravis have been reported in the literature. The nephrotic syndrome may be rela...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：10.1016/j.pneumo.2009.06.003
更新日期：2009-10-01 00:00:00
abstract：:The most frequent benign lesions of the pleura created by asbestos are fibro-hyaline plaques, i.e. thick areas of collagen located on the parietal pleura and gradually becoming calcified. Less common is benign pleural effusion the cause of which is not always easy to determine. To these must be added an extensive pleu...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1988-01-01 00:00:00
abstract：:Adenomatoid cystic malformations of the lung are usually diagnosed during the perinatal period. Its occurrence in adults is rare, this being the fifth case reported in literature. Improved follow-up techniques and in utero treatment have considerably improved prognosis. Differential diagnosis of pulmonary cysts should...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:Infectious complications are rarely observed in the course of sarcoidosis. Only small series or cases reports of infection are described in sarcoidosis. Corticosteroids-induced immune suppression, pulmonary fibrosis and T-CD4 lymphopenia, are often present. Pulmonary nocardiosis is an important cause of opportunistic ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2012.12.001
更新日期：2013-06-01 00:00:00
abstract：:The lymphatic vascular system is widely developed among vertebrates. Lymphatic vessels provide the interstitial fluid (20% of the body weight) drainage through interstitial prelymphatic channels, capillaries, precollectors and collectors flowing into the venous blood. Endothelial cells of capillaries are overlapped an...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：10.1016/j.pneumo.2013.01.005
更新日期：2013-04-01 00:00:00
abstract：OBJECTIVE:To describe the clinical features of dry cough, its socio-professional consequences and impact on patients' quality of life. METHOD:Cross-sectional observational study conducted in daily practice of general practice. RESULTS:One thousand and six hundred and five patients aged 43 years, 52.2% of whom were me...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2010.12.009
更新日期：2011-10-01 00:00:00
abstract：INTRODUCTION:Neurogenic mediastinal tumors are tumors develop at the expense of peripheral nerve elements of the mediastinum, the sympathetic nervous tissue and paraganglia. The series that we propose has the distinction of a high frequency of malignant forms and a wealth of clinical symptomatology. METHODS:This is a ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2016.05.002
更新日期：2016-10-01 00:00:00
abstract：:Gaucher's disease is a not exceptional lysosomial disease in Tunisia. Type 1 is by far the most common one. Pulmonary involvement is considered to be rare in type 1 Gaucher's disease. Pulmonary hypertension, infiltration of the lungs with Gaucher cells, and severe hypoxemia due to intrapulmonary arterial-venous shunts...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2011.07.002
更新日期：2012-02-01 00:00:00
abstract：:Recent studies on smoking conducted in the ivory coast have been sparse despite increasingly aggressive tobacco company campaigns. The purpose of this prospective study was to examine the influence of medical specialty on patient knowledge, attitude and smoking behavior among people consulting three university hospita...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/s0761-8417(04)72102-1
更新日期：2004-09-01 00:00:00
abstract：:Lung transplantation is proposed for young patients with a severe disease that can be expected to be fatal within less than two or three years. The main indications are chronic respiratory failure induced by chronic obstructive lung disease, cystic fibrosis or pulmonary fibrosis, and severe primary or secondary (Eisen...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：2000-11-01 00:00:00
abstract：:Assessment of daily physical activity (DPA) is a major element in the development of respiratory rehabilitation. The aim of this study was to evaluate the DPA and the daily energy expenditure (DEE) in adult patients with cystic fibrosis. Thirty adult patients (16 women, 14 men, mean age 27.1±8.4 years) with cystic fib...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2012.11.006
更新日期：2013-02-01 00:00:00
abstract：:There are three hypotheses to explain the relation between allergens and other factors and the onset of atopy: the hygiene hypothesis, the TH2 like hypothesis and the allergenic hypothesis. None of them have been confirmed. It seems necessary to wait for the results of prospective studies before giving recommendations...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：2003-04-01 00:00:00
abstract：:A narghile is a water-pipe used to smoke a tobacco preparation. As the smoker inhales, the tobacco smoke is sucked down from the bowl and then bubbles up through the water into the air of the smoke chamber and then through the hose to the smoker. Its origins are mysterious and controversial. Nevertheless it remains, u...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：10.1016/j.pneumo.2009.08.010
更新日期：2009-12-01 00:00:00
abstract：:In order to determine the exact significance and origin of lactate dehydrogenases (LDH) present in pleural effusions, LDH and their enzymes were assayed in the serum and pleural fluid of 60 patients with wet pleurisy and in the main blood cells (haematocytes, polymorphonuclears mononuclears) found in pleural fluids. O...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Nicardipine is a commonly used anti-hypertensive drug for acute situations. We report the case of a 55-year-old man with hypoxemic pneumonia, who presented a worsening of his hypoxia secondary to the injection of this calcium channel inhibitor (CCI). This side effect was probably caused by inhibition of hypoxic pulmon...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2011.08.003
更新日期：2012-06-01 00:00:00
abstract：:Pulmonary invasive aspergillosis is a frequent and poor prognosis complication of immunodeficiency and prolonged neutropenia. Its treatment is usually based on amphotericin given as intravenous infusion at 1 to 1.25 mg/kg/d. Use of lipid carriers give the opportunity to administrated higher dose, 5 mg/kg/d, with respe...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：:Sarcoidosis is a diffuse granulomatosis predominately with mediastino-pulmonary localizations. A wide range of extrathoracic localizations can also occur and when they are the initial manifestation, may lead to misdiagnosis. We observed a rare case of peritoneal sarcoidosis revealed by a surgical emergency. ...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:The authors report 2 cases of acute hepatic failure secondary to a pulmonary embolism, the [atypical] symptomatology of which considerably interfered with diagnosis. A review of the literature confirms the rarity of embolic pathology as causing acute cardiac liver. The authors emphasize the importance of echotomograph...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Intrathoracic coelomic cysts are benign embryonic tumors with a mesothelial lining. The aim of this work was to review possible localizations (pleuropericardic and other), the remaining surgical indications, and the current situation of minimally invasive techniques. We reviewed retrospectively, 28 cases of intrathora...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Surgery is the most effective treatment of lung cancer provided that there is complete resection. Even though the results in the early stages of small cell lung cancers (SCLC) are encouraging, many oncologists still consider SCLC a contra-indication. The authors report their experience. They retrospectively reviewed t...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：10.1016/j.pneumo.2009.02.001
更新日期：2009-06-01 00:00:00
abstract：:Medical Images are components of the so-called "Medical Imaging Folder". This folder is a subset of the so-called "Medical Folder", part of the "Patient Folder. The G8 promotes the concept of a "Global Information Society for Health. Within this society, the Patient Folder is seen either from a healthcare organization...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：2000-04-01 00:00:00
abstract：:In adults, mediastinal neurogenic tumours constitute the third group of mediastinal tumours, after thymomas and lymphomas. If the group of neurogenic tumour is frequent, each type of tumour is relatively unusual in everyday's clinic. Among them, nerve sheath tumours are the more frequent, followed by tumour of the aut...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：10.1016/j.pneumo.2009.12.010
更新日期：2010-02-01 00:00:00
abstract：:The clinician engages his penal, private and administrative responsibilities whenever he performs a medical act. Common law applies for private practice, as is the case of most pneumologists. Actually, there is little common law jurisprudence directly concerning pneumological situations. We present here the current tr...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：:Patients with hematology disease in post-chemotherapy medullary aplasia are susceptible to life-threatening bronchopulmonary mycoses, especially aspergillosis. Other less common pulmonary mycoses are also observed. We report 4 cases due to Penicillium purpurogenum, Acromonium strictum and Scedosporium apiospermum (n =...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：:We report the case of a 57-year-old patient with primary malignant melanoma of the mediastinum who survived nine months despite immunotherapy, radiotherapy and chemotherapy. The primary nature of the intrathoracic melanoma was difficult to prove. Definitive diagnosis was based on the uniform morphology of the melanoma...
journal_title：Revue de pneumologie clinique
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
