Ryanodine prolongs Ca-currents while suppressing contraction in rat ventricular muscle cells.

abstract：:1. The nature and cellular mechanisms that are responsible for endothelium-dependent relaxations resistant to indomethacin and NG-nitro-L-arginine methyl ester (L-NAME) were investigated in phenylephrine (PE) precontracted isolated carotid arteries from the rabbit. 2. In the presence of the cyclo-oxygenase inhibitor, ...

journal_title：British journal of pharmacology

authors： Dong H,Waldron GJ,Galipeau D,Cole WC,Triggle CR

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is increasing evidence that potassium channels are involved in the cardiovascular dysfunction of sepsis. This evidence was obtained after the systemic inflammation, cardiovascular dysfunction and organ damage had developed. Here we have studied the consequences of early interference with po...

journal_title：British journal of pharmacology

authors： Sordi R,Fernandes D,Heckert BT,Assreuy J

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Adenosine is considered to be an important modulator of intestinal motility. This study was undertaken to investigate the role of adenosine in the modulation of contractility in the mouse duodenum and to characterize the adenosine receptor subtypes involved. EXPERIMENTAL APPROACH:RT-PCR was used...

journal_title：British journal of pharmacology

authors： Zizzo MG,Mastropaolo M,Lentini L,Mulè F,Serio R

更新日期：2011-11-01 00:00:00

abstract：:1. In this study 3 protocols were utilized to determine the role of endogenous kinins in the resistance of the inbred Dahl (Rapp) salt-resistant (SR/Jr) rats to high salt diet-induced blood pressure elevation. 2. The bradykinin B2 receptor antagonist, Hoe 140 (D-Arg[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin) at doses of ei...

journal_title：British journal of pharmacology

authors： Mukai H,Fitzgibbon WR,Ploth DW,Margolius HS

更新日期：1998-05-01 00:00:00

abstract：:We investigated the ability of N-benzyl-N-ethyl-2-(7,8-dihydro-7-methyl-8-oxo-2-phenyl-9H-purin-9-yl)acetamide (AC-5216), a novel mitochondrial benzodiazepine receptor (MBR) ligand, to produce anti-anxiety and antidepressant-like effects in various animal models. AC-5216 showed high affinity for MBRs prepared from rat...

journal_title：British journal of pharmacology

authors： Kita A,Kohayakawa H,Kinoshita T,Ochi Y,Nakamichi K,Kurumiya S,Furukawa K,Oka M

更新日期：2004-08-01 00:00:00

abstract：:1. Ginsenosides, the active ingredients extracted from Panax ginseng, have been shown to promote nitric oxide (NO) release in bovine aortic endothelial cells. Since the endothelial cells and the perivascular nerves in penile corpus cavernosum contain NO synthase and an NO-like substance has been shown to be released f...

journal_title：British journal of pharmacology

authors： Chen X,Lee TJ

更新日期：1995-05-01 00:00:00

abstract：:1. A series of analogues of angiotensin II (AT(II)) has been used in the present experiments to characterize receptors for AT(II) in intestinal (rat stomach strip, rat colon) and vascular (rabbit aorta) smooth muscles. Two types of compounds have been chosen: (a) agonists with reduced potency, in which 4-Tyr, 6-His or...

journal_title：British journal of pharmacology

authors： Park WK,Regoli D,Rioux F

更新日期：1973-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Atherosclerosis is associated with reduced vascular hydrogen sulfide (H2 S) biosynthesis. GYY4137 is a novel slow-releasing H2 S compound that may effectively mimic the time course of H2 S release in vivo. However, it is not known whether GYY4137 affects atherosclerosis. EXPERIMENTAL APPROACH:RA...

journal_title：British journal of pharmacology

authors： Liu Z,Han Y,Li L,Lu H,Meng G,Li X,Shirhan M,Peh MT,Xie L,Zhou S,Wang X,Chen Q,Dai W,Tan CH,Pan S,Moore PK,Ji Y

更新日期：2013-08-01 00:00:00

abstract：:1. In the zymosan rat air pouch model of inflammation we have assessed the time dependence of phospholipase A2 (PLA2) accumulation in the inflammatory exudates as well as cell migration, myeloperoxidase activity, prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) levels. 2. A significant increase in PLA2 activity was d...

journal_title：British journal of pharmacology

authors： Payá M,Terencio MC,Ferrándiz ML,Alcaraz MJ

更新日期：1996-04-01 00:00:00

abstract：:1. This study investigated whether (a) cannabinoid CB(1) receptor knockout (CB(1)(-/-)) mice displayed altered gastrointestinal transit and (b) cannabinoid CB(1) and opioid receptors functionally interact in the regulation of gastrointestinal transit. 2. Gastrointestinal transit was assessed by the Whole Gastrointesti...

journal_title：British journal of pharmacology

authors： Carai MA,Colombo G,Gessa GL,Yalamanchili R,Basavarajappa BS,Hungund BL

更新日期：2006-08-01 00:00:00

abstract：:1. We studied the effect of bradykinin on plasma exudation in the airways of the anaesthetized guinea-pig in vivo. Tissue content of extravasated Evans blue dye was used as an index of protein exudation in the larynx, trachea, main bronchi and intrapulmonary airways (i.p.a.). 2. Bradykinin increased the content of Eva...

journal_title：British journal of pharmacology

authors： Rogers DF,Dijk S,Barnes PJ

更新日期：1990-11-01 00:00:00

abstract：:Muscularis mucosa of the distal oesophagus of the opossum contains nerves which release acetylcholine and substance P(SP)-like material on field stimulation. The release of SP-like material appeared to be inhibited by the presence of exogenous muscarinic agonists and potentiated by muscarinic antagonists. Analysis of ...

journal_title：British journal of pharmacology

authors： Daniel EE,Jury J,Robotham KH

更新日期：1986-07-01 00:00:00

abstract：:Pulmonary hypertension (PH) is a rare, progressive pulmonary vasculopathy characterized by increased mean pulmonary arterial pressure, pulmonary vascular remodelling and right ventricular failure. Current treatments are not curative, and new therapeutic strategies are urgently required. Clinical and preclinical eviden...

journal_title：British journal of pharmacology

authors： Scott TE,Kemp-Harper BK,Hobbs AJ

更新日期：2019-06-01 00:00:00

abstract：:A study has been made of the pharmacology of the 5-hydroxytryptamine (5-HT)-induced depolarization responses that can be recorded extracellularly from the rat isolated cervical vagus nerve. Phenylbiguanide (PBG) and 2-methyl-5-hydroxytryptamine (2-methyl-5-HT) were found to mimic the effects of 5-HT on the vagus nerve...

journal_title：British journal of pharmacology

authors： Ireland SJ,Tyers MB

更新日期：1987-01-01 00:00:00

abstract：:1. In vivo microdialysis has been used to investigate the concentration of various amino acids and lactate in the extracellular fluid of the rat cortex following focal ischaemia, the probe being placed in the core of the infarct area. 2. An ischaemic infarct was produced in the cortex by use of a photochemical dye (Ro...

journal_title：British journal of pharmacology

authors： Baldwin HA,Williams JL,Snares M,Ferreira T,Cross AJ,Green AR

更新日期：1994-05-01 00:00:00

abstract：:1. The class III antiarrhythmic azimilide has previously been shown to inhibit I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes. Because HERG channels underly the conductance I(Kr), in human heart, the effects of azimilide on HERG channels expressed in Xenopus oocyt...

journal_title：British journal of pharmacology

authors： Busch AE,Eigenberger B,Jurkiewicz NK,Salata JJ,Pica A,Suessbrich H,Lang F

更新日期：1998-01-01 00:00:00

abstract：:1. Impairment of nitric oxide (NO)/cyclic GMP production and/or increased activities of thromboxane A2 (TXA2) and endothelin-1 (ET-1) have been associated with pulmonary hypertension. We have analysed the interactions of noradrenaline (NA), the TXA2-mimetic U46619 and ET-1 with the relaxation induced via cyclic GMP in...

journal_title：British journal of pharmacology

authors： Pérez-Vizcaíno F,Villamor E,Duarte J,Tamargo J

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor agonists display a promising analgesic profile in preclinical studies. However, supraspinal N/OFQ produced hyperalgesia in rodents and such effects have not been addressed in primates. Thus, the aim of this study was to investigate the effects...

journal_title：British journal of pharmacology

authors： Ding H,Hayashida K,Suto T,Sukhtankar DD,Kimura M,Mendenhall V,Ko MC

更新日期：2015-07-01 00:00:00

abstract：:1. This study investigated the importance of renal sympathetic nerves in regulating sodium and water excretion from the kidneys of stroke prone spontaneously hypertensive and 2K1C Goldblatt hypertensive rats anaesthetized with chloralose/urethane (17.5/300 mg initially and supplemented at regular intervals), and prepa...

journal_title：British journal of pharmacology

authors： Chamienia AL,Johns EJ

更新日期：1996-08-01 00:00:00

abstract：:The effect of propranolol, a beta-adrenoceptor blocking agent, has been investigated on gastric acid secretion in pylorus and cardiac-ligated rats. Compared to the control group, propranolol significantly diminished the gastric acid secretion, and inhibited the formation of gastric ulceration. ...

journal_title：British journal of pharmacology

authors： Danhof IE,Geumei A

更新日期：1972-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Mast cells are important in allergic reactions. Here, we assessed the anti-allergic effects of the anti-cancer drug tozasertib specifically regarding regulatory effects on mast cell activation. EXPERIMENTAL APPROACH:Tozasertib effects on mast cell degranulation were determined by measuring β-hex...

journal_title：British journal of pharmacology

authors： Zhang LN,Ji K,Sun YT,Hou YB,Chen JJ

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Accumulated evidence suggests that oxidative stress is involved in amyloid beta (Abeta)-induced cognitive dysfunction. Silibinin (silybin), a flavonoid derived from the herb milk thistle (Silybum marianum), has been shown to have antioxidative properties; however, it remains unclear whether silib...

journal_title：British journal of pharmacology

authors： Lu P,Mamiya T,Lu LL,Mouri A,Zou L,Nagai T,Hiramatsu M,Ikejima T,Nabeshima T

更新日期：2009-08-01 00:00:00

abstract：:1. Strength-duration curves for threshold mechanical responses to single transmural stimuli were identical for rat and guinea-pig detrusor. In both species atropine had no effect on the curves, but the curves were shifted to the right by nerve blockade with tetrodotoxin (TTX), and by blockade of P2-purinoceptors with ...

journal_title：British journal of pharmacology

authors： Brading AF,Williams JH

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:K(v)11.1 channels are involved in regulating cellular excitability in various tissues including brain, heart and smooth muscle. In these tissues, at least two isoforms, K(v)11.1a and K(v)11.1b, with different kinetics, are expressed. K(v)11.1 activators are potential therapeutic agents, but their...

journal_title：British journal of pharmacology

authors： Larsen AP,Bentzen BH,Grunnet M

更新日期：2010-10-01 00:00:00

abstract：:In recent years there has been a growing recognition of the influence of sex on brain structure and function, and in relation, on the susceptibility, prevalence and response to treatment of psychiatric disorders. Most theories and descriptions of the effects of sex on the brain are dominated by an analogy to the curre...

journal_title：British journal of pharmacology

authors： Joel D,Yankelevitch-Yahav R

更新日期：2014-10-01 00:00:00

abstract：:1. This study examined beta-adrenoceptor signalling in cardiac tissues following infusion of isoprenaline (400 microg kg(-1) h(-1)) or vehicle to rats for 14 days. 2. Isoprenaline infusion caused marked hypertrophy of atria and ventricles and reduced the resting rate of spontaneously beating right atria and the basal ...

journal_title：British journal of pharmacology

authors： McMartin L,Summers RJ

更新日期：1999-06-01 00:00:00

abstract：:1. The effects of several agonists of the metabotropic glutamate receptor (mGluR) were studied in adult rat striatal slices by measuring (i) KCl (30 mM)-induced output of previously taken up D-[3H]-aspartate (Asp), (ii) forskolin (30 microM)-induced adenosine 3':5'-cyclic monophosphate (cyclic AMP) accumulation and (i...

journal_title：British journal of pharmacology

authors： Lombardi G,Alesiani M,Leonardi P,Cherici G,Pellicciari R,Moroni F

更新日期：1993-12-01 00:00:00

abstract：:Current treatments of schizophrenia are compromised by their inability to treat all symptoms of the disease and their side-effects. Whilst existing antipsychotic drugs are effective against positive symptoms, they have negligible efficacy against the prefrontal cortex (PFC)-associated cognitive deficits and negative s...

journal_title：British journal of pharmacology

authors： Pratt JA,Winchester C,Egerton A,Cochran SM,Morris BJ

更新日期：2008-03-01 00:00:00

abstract：:1 The cardiovascular effects of the anthelmintic drug diethylcarbamazine citrate (DECC) were examined in cats anaesthetized with pentobarbitone. There were two quite distinct haemodynamic responses, an initial transient hypotension (occurring within 10 s of an intravenous injection) and a pronounced secondary hyperten...

journal_title：British journal of pharmacology

authors： Abaitey AK,Parratt JR

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Baclofen (a GABA(B) receptor agonist) is the most commonly used anti-spasticity agent in clinical practice. While effective when administered spinally or systemically, the development of progressive tolerance represents a serious limitation for its long-term use. The goal of the present study was...

journal_title：British journal of pharmacology

authors： Oshiro M,Hefferan MP,Kakinohana O,Lukacova N,Sugahara K,Yaksh TL,Marsala M

更新日期：2010-11-01 00:00:00