Characterization of ultraviolet light-induced relaxation of the isolated duodenum of the rat.

abstract：:1 The present study comprised treatment of healthy male rats with Delta(9)-tetrahydrocannabinol (THC, 10 mg kg(-1), p.o.), and combinations of THC with benzoflavone moiety (BZF, 10 and 20 mg kg(-1), p.o.) isolated from Passiflora incarnata Linneaus, over a period of 30 days. 2 Upon 30-days chronic administrations, the...

journal_title：British journal of pharmacology

authors： Dhawan K,Sharma A

更新日期：2003-01-01 00:00:00

abstract：:1. We have studied the ability of some adrenergic neurone blocking agents to inhibit the tracheal relaxant actions of isoprenaline, theophylline and the potassium channel openers (KCOs) BRL 38227, pinacidil and RP 52891. 2. BRL 38227, isoprenaline, pinacidil, RP 52891 and theophylline each caused concentration-depende...

journal_title：British journal of pharmacology

authors： Berry JL,Small RC,Foster RW

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Rhythmical transient constrictions of the lymphatic vessels provide the means for efficient lymph drainage and interstitial tissue fluid balance. This activity is critical during inflammation, to avoid or limit oedema resulting from increased vascular permeability, mediated by the release of vari...

journal_title：British journal of pharmacology

authors： Rehal S,Blanckaert P,Roizes S,von der Weid PY

更新日期：2009-12-01 00:00:00

abstract：:N-methyl-d-aspartate (NMDA) receptors have been demonstrated to be a pivotal target for ethanol action. The present study examined the actions of acute ethanol exposure on NMDA-induced responses and the acute tolerance to ethanol actions in rat sympathetic preganglionic neurons (SPNs) in vitro and in vivo. NMDA (50 mi...

journal_title：British journal of pharmacology

authors： Lin HH,Hsieh WK,Shiu JY,Chiu TH,Lai CC

更新日期：2003-11-01 00:00:00

abstract：:1. To obtain direct evidence of abnormal eicosanoid biosynthesis in rats injected with anti-glomerular-basement-membrane antibodies (a-GBM), products derived from thromboxane A2 (TXA2) and prostacyclin (PGI2) were measured in 24 h urine collections before and after a-GBM. 2. Administration of a-GBM (9.5 mg) caused alb...

journal_title：British journal of pharmacology

authors： Ward PS,Fuller RW,Ritter JM,Cashman SJ,Rees AJ,Dollery CT

更新日期：1991-07-01 00:00:00

abstract：:1. Recent studies demonstrated that the cardiac calpain system is activated during ischaemic events and is involved in cardiomyocyte injury. The aim of this study was to investigate the contribution of AT(1) and AT(2) receptors in the regulation of calpain-mediated myocardial damage following myocardial infarction (MI...

journal_title：British journal of pharmacology

authors： Sandmann S,Yu M,Unger T

更新日期：2001-02-01 00:00:00

abstract：:1. A study has been made of the modulation of high-voltage activated transient and sustained calcium currents in cultured neurones of avian ciliary ganglia by nitric oxide (NO) and arachidonic acid. 2. Sodium nitroprusside (100 microM) reduced the transient calcium current (ICa) on average by 31% and the sustained ICa...

journal_title：British journal of pharmacology

authors： Khurana G,Bennett MR

更新日期：1993-06-01 00:00:00

abstract：:1. The present study was designed to characterize the positive inotropic response to DPI 201-106 in isolated papillary muscle strips obtained from heart failure patients undergoing surgery. 2. The positive inotropic responses to isoprenaline and milrinone and cardiac beta-adrenoceptor density were also determined. 3. ...

journal_title：British journal of pharmacology

authors： Böhm M,Diet F,Kemkes B,Wankerl M,Erdmann E

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Excessive production of nitric oxide (NO) by inducible NO synthase (iNOS) is thought to underlie the vascular dysfunction, systemic hypotension and organ failure that characterize endotoxic shock. Plasma levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriu...

journal_title：British journal of pharmacology

authors： Panayiotou CM,Baliga R,Stidwill R,Taylor V,Singer M,Hobbs AJ

更新日期：2010-08-01 00:00:00

abstract：:1. It has recently been shown that both alpha(1)- and alpha(2)-adrenoceptors mediate vasoconstriction in the canine external carotid circulation. The present study set out to identify the specific subtypes (alpha(1A), alpha(1B) and alpha(1D) as well as alpha(2A), alpha(2B) and alpha(2C)) mediating the above response. ...

journal_title：British journal of pharmacology

authors： Willems EW,Valdivia LF,Saxena PR,Villalón CM

更新日期：2001-03-01 00:00:00

abstract：:1. The effect of trimebutine on the voltage-dependent inward Ca2+ current was investigated by the whole-cell voltage-clamp technique in single smooth muscle cells from rabbit ileum. 2. Trimebutine (3-100 microM) reduced the Ca2+ current in a concentration-dependent manner. The inhibitory effect on the Ca2+ current was...

journal_title：British journal of pharmacology

authors： Nagasaki M,Komori S,Ohashi H

更新日期：1993-09-01 00:00:00

abstract：:1. The role of vasoconstrictor 5-HT1-like receptors in the control of vascular reactivity in vivo has been relatively little studied, particularly with regards to venous function. Using an anaesthetized dog model, we have investigated the haemodynamic profile of the selective 5-HT1-like agonist, sumatriptan, focussing...

journal_title：British journal of pharmacology

authors： Drieu la Rochelle C,O'Connor SE

更新日期：1995-10-01 00:00:00

abstract：:1. Heterologous desensitization or intermolecular cross-talk plays a critical role in regulating intracellular signalling by diverse members of the G-protein-coupled receptor superfamily. We have previously established that the alpha and beta isoforms of the human thromboxane A(2) receptor (TP) undergo differential de...

journal_title：British journal of pharmacology

authors： Kelley-Hickie LP,Kinsella BT

更新日期：2004-05-01 00:00:00

abstract：:The abilities of prostaglandin E1 (PGE1), PGE2, PGD2 and PGF2 alpha to antagonize striatal dopamine function were assessed following bilateral and unilateral injections into the striata of the rat and guinea-pig. Three tests were used to assess the effects of the bilateral injections, ability to antagonize dyskinetic ...

journal_title：British journal of pharmacology

authors： Costall B,Holmes SW,Kelly ME,Naylor RJ

更新日期：1985-08-01 00:00:00

abstract：:1. We previously reported that substance P and insulin-like growth factor-1 (IGF-1) synergistically stimulate corneal epithelial wound healing in vitro and in vivo. We wished to identify which portion of the amino acid sequence of substance P might be responsible for this synergism. 2. Corneal epithelial migration was...

journal_title：British journal of pharmacology

authors： Nakamura M,Chikama T,Nishida T

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Two of the most relevant unmet needs in epilepsy are represented by the development of disease-modifying drugs able to affect epileptogenesis and/or the study of related neuropsychiatric comorbidities. No systematic study has investigated the effects of chronic treatment with antipsychotics or an...

journal_title：British journal of pharmacology

authors： Citraro R,Leo A,De Fazio P,De Sarro G,Russo E

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Orally administered withanoside IV (a compound isolated from the roots of Withania somnifera) improved memory deficits in mice with a model of Alzheimer's disease induced by the amyloid peptide Abeta(25-35). Sominone, an aglycone of withanoside IV, was identified as an active metabolite after ora...

journal_title：British journal of pharmacology

authors： Tohda C,Joyashiki E

更新日期：2009-08-01 00:00:00

abstract：:Platelet-activating factor (Paf) has been proposed as a mediator of the gastrointestinal damage in endotoxic shock. The formation of Paf in rat jejunal tissue, determined following extraction and bioassay on rabbit washed platelets has therefore been correlated with the induction of damage following endotoxin administ...

journal_title：British journal of pharmacology

authors： Whittle BJ,Boughton-Smith NK,Hutcheson IR,Esplugues JV,Wallace JL

更新日期：1987-09-01 00:00:00

abstract：:1. In order to assess the role of different ionic currents in hypoxia-induced action potential shortening, we investigated the effects of blockers of voltage-dependent and ATP-sensitive K(+)-channel on the membrane potential of hypoxic rabbit hearts and papillary muscles. The response to blocking of the inward rectifi...

journal_title：British journal of pharmacology

authors： Ruiz Petrich E,Leblanc N,deLorenzi F,Allard Y,Schanne OF

更新日期：1992-08-01 00:00:00

abstract：:The effects of high (20 mM) concentrations of caffeine were studied on the transmembrane voltage and currents in rat single ventricular myocytes by the whole cell configuration of the patch clamp technique. Rapid application of caffeine released Ca2+ from the sarcoplasmic reticulum and induced a Ni(2+)-sensitive trans...

journal_title：British journal of pharmacology

authors： Varro A,Hester S,Papp JG

更新日期：1993-08-01 00:00:00

abstract：:1 Rat isolated perfused hearts with the right sympathetic nerves attached were loaded with [3H]-(-)-noradrenaline. The nerves were stimulated with up to 40 trains of 10 pulses every min at 1 Hz, and the evoked increases of [3H-]noradrenaline overflow into the perfusate, of right atrial tension development and ventricu...

journal_title：British journal of pharmacology

authors： Fuder H,Muscholl E,Spemann R

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Transforming growth factor beta1 (TGFbeta1) is generated in atherosclerotic and injured vessel walls. We examined whether the endothelial-to-mesenchymal transdifferentiation induced by TGFbeta1 affects endothelial functions. EXPERIMENTAL APPROACH:Bovine aortic endothelial cells (BAECs) were trea...

journal_title：British journal of pharmacology

authors： Watanabe M,Oike M,Ohta Y,Nawata H,Ito Y

更新日期：2006-10-01 00:00:00

abstract：:1 A newly synthesized substance P (SP) analogue, (D-Pro2, D-Trp7,9)-SP, specifically antagonizes the contractile effects of SP on the guinea-pig isolated taenia coli. In addition, previous studies had indicated that the SP analogue per se is capable of contracting this preparation. The results of the present study on ...

journal_title：British journal of pharmacology

authors： Håkanson R,Hörig J,Leander S

更新日期：1982-12-01 00:00:00

abstract：:1 This study investigated the effects of soluble complement receptor type 1 (sCR1) or sCR1sLex, agents which function as a complement inhibitor or as a combined complement inhibitor and selectin adhesion molecule antagonist, respectively, on the infarct size and cardiac troponin T (cTnT) release caused by regional myo...

journal_title：British journal of pharmacology

authors： Zacharowski K,Otto M,Hafner G,Marsh HC Jr,Thiemermann C

更新日期：1999-11-01 00:00:00

abstract：:Ouabain was administered at a loading dose of 3 mug/kg followed by an infusion at a rate of 1 mug/kg-1 min-1 in order to produce severe dysrhythmia in dogs within 60 minutes. Similarly, digitoxin at a loading dose of 9 mug/kg followed by an infusion at a rate of 3 mug kg-1 min-1 was administered to compare its effect ...

journal_title：British journal of pharmacology

authors： Dutta S,Marks BH,Schoener EP

更新日期：1977-01-01 00:00:00

abstract：:1. Effects of morphine sulphate (1.25, 2.5, 5, 10, 20 and 40 mg/kg i.p.) on locomotor activity of male rats were observed for 8 h after single doses in non-tolerant rats. The lower three doses had only an excitatory effect, whereas the higher three doses caused initial depression followed by a delayed excitatory effec...

journal_title：British journal of pharmacology

authors： Babbini M,Davis WM

更新日期：1972-10-01 00:00:00

abstract：:We examined the mechanisms underlying leukotriene D4- (LTD4) induced constriction of human small (300 - 500 micron i.d.) bronchioles, and the effect of LTD4 on ion currents and Ca2+ transients in smooth muscle cells (SMC) isolated from these bronchioles. LTD4 caused a concentration-dependent bronchoconstriction with a...

journal_title：British journal of pharmacology

authors： Snetkov VA,Hapgood KJ,McVicker CG,Lee TH,Ward JP

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Positive modulators of small conductance Ca(2+)-activated K(+) channels (SK1, SK2, and SK3) exert hyperpolarizing effects that influence the activity of excitable and non-excitable cells. The prototype compound 1-EBIO or the more potent compound NS309, do not distinguish between the SK subtypes a...

journal_title：British journal of pharmacology

authors： Hougaard C,Eriksen BL,Jørgensen S,Johansen TH,Dyhring T,Madsen LS,Strøbaek D,Christophersen P

更新日期：2007-07-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) increased adenosine 3' : 5'-cyclic monophosphate (cyclic AMP) formation in tracheal epithelial cells and concomitantly decreased the production/secretion of immunoreactive endothelin (irET). Naturally occurring prostanoids and selective and non-selective EP receptor agonists showed the foll...

journal_title：British journal of pharmacology

authors： Pelletier S,Dubé J,Villeneuve A,Gobeil F Jr,Yang Q,Battistini B,Guillemette G,Sirois P

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Early soluble epoxide hydrolase inhibitors (sEHIs) such as 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA) are effective anti-hypertensive and anti-inflammatory agents in various animal models. However, their poor metabolic stability and limited water solubility make them difficult to use pha...

journal_title：British journal of pharmacology

authors： Liu JY,Tsai HJ,Hwang SH,Jones PD,Morisseau C,Hammock BD

更新日期：2009-01-01 00:00:00