Prolonged partial venoarterial bypass: physiologic, biochemical, and hematologic responses.

Abstract:

:Prolonged veno arterial extracorporeal bypass (50-80% of cardiac output) was evaluated in normal, unanesthetized sheep. The evaluation protocol included serial measurements of hemodynamics, pulmonary and renal function, serum enzymes to detect organ damage, and detailed studies of coagulation and platelets. Blood exposure surfaces were primarily polyvinyl chloride and silicone rubber. Gas interfaces were carefully excluded with the exception of four experiments utilizing bubble oxygenators. Heparin dose was titrated to maintain activated clotting to two to three times baseline. Characteristics of 48 hour uncomplicated extracorporeal circulation in 8 sheep included normal hemodynamics, mild respiratory alkolosis negligable hemolysis, slight gradual increase in heart, liver, and muscle enzymes. The most significant changes occurred in coagulation and platelets characterized by an initial reduction in coagulation factors with a continued reduction in platelet count and return to normal clotting factors during extracorporeal circulation. This is followed by a two times normal increase in platelets and fibrinogen following extracorporeal circulation.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Bartlett RH,Fong SW,Burns NE,Gazzaniga AB

doi

10.1097/00000658-197412000-00010

subject

Has Abstract

pub_date

1974-12-01 00:00:00

pages

850-6

issue

6

eissn

0003-4932

issn

1528-1140

journal_volume

180

pub_type

杂志文章
  • Total laparoscopic pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: oncologic advantages over open approaches?

    abstract:OBJECTIVE:To directly compare the oncologic outcomes of TLPD and OPD in the setting of pancreatic ductal adenocarcinoma. BACKGROUND:Total laparoscopic pancreaticoduodenectomy (TLPD) has been demonstrated to be feasible and may have several potential advantages over open pancreaticoduodenectomy (OPD), including lower b...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000937

    authors: Croome KP,Farnell MB,Que FG,Reid-Lombardo KM,Truty MJ,Nagorney DM,Kendrick ML

    更新日期:2014-10-01 00:00:00

  • Preoperative systemic chemoimmunotherapy and sequential resection for unresectable hepatocellular carcinoma.

    abstract:OBJECTIVE:To examine the surgical and pathologic findings of 15 patients who had initially unresectable hepatocellular carcinoma (HCC) and received preoperative systemic chemoimmunotherapy and sequential resection. SUMMARY BACKGROUND DATA:More than 80% of patients with HCC present for treatment at an unresectable stag...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200102000-00013

    authors: Lau WY,Leung TW,Lai BS,Liew CT,Ho SK,Yu SC,Tang AM

    更新日期:2001-02-01 00:00:00

  • Prognostic value of preoperative clinical staging assessed by computed tomography in resectable gastric cancer patients: a viewpoint in the era of preoperative treatment.

    abstract:BACKGROUND:In the era of pre- or perioperative therapy for gastric cancer, clinical staging before treatment appears to be increasingly important for prognosis, yet there are no data on the subject for resectable gastric cancer patients. OBJECTIVES:To evaluate the prognostic role of preoperative locoregional staging i...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181ca69a7

    authors: Park SR,Kim MJ,Ryu KW,Lee JH,Lee JS,Nam BH,Choi IJ,Kim YW

    更新日期:2010-03-01 00:00:00

  • Frailty as a Predictor of Death or New Disability After Surgery: A Prospective Cohort Study.

    abstract:OBJECTIVE:To compare the accuracy of the modified Fried Index (mFI) and the Clinical Frailty Scale (CFS) to predict death or patient-reported new disability 90 days after major elective surgery. BACKGROUND:The association of frailty with patient-reported outcomes, and comparisons between preoperative frailty instrumen...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002967

    authors: McIsaac DI,Taljaard M,Bryson GL,Beaulé PE,Gagné S,Hamilton G,Hladkowicz E,Huang A,Joanisse JA,Lavallée LT,MacDonald D,Moloo H,Thavorn K,van Walraven C,Yang H,Forster AJ

    更新日期:2020-02-01 00:00:00

  • Anti-TNF Therapy Is Associated With an Increased Risk of Postoperative Morbidity After Surgery for Ileocolonic Crohn Disease: Results of a Prospective Nationwide Cohort.

    abstract:OBJECTIVE:To determine the risk factors of morbidity after surgery for ileocolonic Crohn disease (CD). SUMMARY BACKGROUND DATA:The risk factors of morbidity after surgery for CD, particularly the role of anti-TNF therapy, remain controversial and have not been evaluated in a large prospective cohort study. METHODS:Fr...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002017

    authors: Brouquet A,Maggiori L,Zerbib P,Lefevre JH,Denost Q,Germain A,Cotte E,Beyer-Berjot L,Munoz-Bongrand N,Desfourneaux V,Rahili A,Duffas JP,Pautrat K,Denet C,Bridoux V,Meurette G,Faucheron JL,Loriau J,Guillon F,Vicaut E

    更新日期:2018-02-01 00:00:00

  • The use of transcutaneous oxygen tension measurements in the diagnosis of peripheral vascular insufficiency.

    abstract::Transcutaneous tissue oxygen tension (PtcO2) was evaluated as a noninvasive diagnostic test for peripheral arterial insufficiency; PtcO2 was measured at rest, during exercise, and following exercise at three leg sites in 36 controls and 138 patients with exercise-induced leg pain. Resting foot PtcO2 differed significa...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198408000-00007

    authors: Byrne P,Provan JL,Ameli FM,Jones DP

    更新日期:1984-08-01 00:00:00

  • Anticatabolic effects of avoiding preoperative fasting by intravenous hypocaloric nutrition: a randomized clinical trial.

    abstract:OBJECTIVE:We tested the hypothesis that the avoidance of preoperative fasting by hypocaloric nutrition attenuates protein catabolism after surgery. SUMMARY BACKGROUND DATA:Prolonged fasting before major abdominal procedures has been demonstrated to accentuate the catabolic response to surgery. METHODS:Twenty-two pati...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e31818842d8

    authors: Schricker T,Meterissian S,Lattermann R,Adegoke OA,Marliss EB,Mazza L,Eberhart L,Carli F,Nitschman E,Wykes L

    更新日期:2008-12-01 00:00:00

  • Surgical aspects of sclerosing cholangitis. Results in 178 patients.

    abstract::Of 178 patients with sclerosing cholangitis treated since 1950, 88 patients had associated inflammatory bowel disease, 72 had no such history, and 18 had iatrogenic injury or stone disease. A total of 233 biliary operations were performed, with a 75% rate of temporary improvement after initial operation. Subsequent op...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199010000-00017

    authors: Martin FM,Rossi RL,Nugent FW,Scholz FJ,Jenkins RL,Lewis WD,Gagner M,Foley E,Braasch JW

    更新日期:1990-10-01 00:00:00

  • A randomized trial of hemithyroidectomy versus Dunhill for the surgical management of asymmetrical multinodular goiter.

    abstract:OBJECTIVE:To assess the immediate and long-term clinical results of 2 different surgical procedures for the treatment of asymmetrical multinodular goiter (AMG). BACKGROUND:Half of the patients presenting with a single benign thyroid nodule have contralateral subclinical disease. There is a controversy whether these pa...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0b013e318272df62

    authors: Sancho JJ,Prieto R,Dueñas JP,Ribera C,Ripollés J,Larrad A,Sitges-Serra A

    更新日期:2012-11-01 00:00:00

  • Improved kidney graft function after preservation using a novel hypothermic machine perfusion device.

    abstract:OBJECTIVE:To study graft function and ischemia/reperfusion injury of porcine kidneys after preservation with the new Groningen Machine Perfusion (GMP) system versus static cold storage (CS). INTRODUCTION:The increasing proportion of marginal and nonheart beating donors necessitates better preservation methods to maint...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31815c4019

    authors: Maathuis MH,Manekeller S,van der Plaats A,Leuvenink HG,'t Hart NA,Lier AB,Rakhorst G,Ploeg RJ,Minor T

    更新日期:2007-12-01 00:00:00

  • Patient selection for cytoreductive surgery in colorectal peritoneal carcinomatosis using serum tumor markers: an observational cohort study.

    abstract:OBJECTIVE:There were 2 objectives: first, to investigate how many patients were excluded from surgery on the basis of the radiological extent of the peritoneal carcinomatosis (PC) or the clinical examination; and second, to develop a score based primarily on serum tumor markers (STMs) that could predict short cancer-sp...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318254f281

    authors: Cashin PH,Graf W,Nygren P,Mahteme H

    更新日期:2012-12-01 00:00:00

  • Primary Open Versus Closed Implantation Strategy for Totally Implantable Venous Access Ports: The Multicentre Randomized Controlled PORTAS-3 Trial (DRKS 00004900).

    abstract:OBJECTIVES:PORTAS-3 was designed to compare the frequency of pneumothorax or haemothorax in a primary open versus closed strategy for port implantation. BACKGROUND DATA:The implantation strategy for totally implantable venous access ports with the optimal benefit/risk ratio remains unclear. METHODS:PORTAS-3 was a mul...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003705

    authors: Hüttner FJ,Bruckner T,Hackbusch M,Weitz J,Bork U,Kotschenreuther P,Heupel O,Kümmel S,Schlitt HJ,Mattulat M,Pintér L,Seiler CM,Gutt CN,Nottberg HS,Pohl A,Ghanem F,Meyer T,Imdahl A,Neudecker J,Müller VA,Gehrig T,R

    更新日期:2020-12-01 00:00:00

  • A Longitudinal Assessment of Outcomes and Healthcare Resource Utilization After Immediate Breast Reconstruction-Comparing Implant- and Autologous-based Breast Reconstruction.

    abstract:OBJECTIVES:Immediate breast reconstruction (IBR) after mastectomy for cancer has increased in recent years, yet long-term, modality-specific comparative data are lacking. We performed this study to compare short- and long-term outcomes after expander, autologous (AT), and direct-to-implant (DI) breast reconstruction. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001457

    authors: Fischer JP,Fox JP,Nelson JA,Kovach SJ,Serletti JM

    更新日期:2015-10-01 00:00:00

  • Colon surgery for cancer in the very elderly. Cost and 3-year survival.

    abstract::Is colon cancer surgery justified in the very elderly from the standpoint of cost and 3-year survival rates? Two hundred eighty patients undergoing major surgery for colon cancer during 1981-1983 were divided into a group of 61 with ages greater than or equal to 80 (GE80) and 219 less than 80 (LT80). Although those GE...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198602000-00003

    authors: Hobler KE

    更新日期:1986-02-01 00:00:00

  • Selective gastric vagotomy and drainage for duodenal ulcer: a 10-13-year follow-up study.

    abstract::From 1964 to 1968 selective gastric vagotomy (SGV) and drainage was performed in 174 patients. Of these, 105 patients were followed-up 10-13 years after operation; 56 were dead. Ulcers recurred in 18 patients. The cumulated recurrence rate after 13 years (life table method) was 15% (95% confidence limits: 8-23). The m...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198112000-00004

    authors: Siim C,Lublin HK,Jensen HE

    更新日期:1981-12-01 00:00:00

  • Multiple subcritical arterial stenoses: effect on poststenotic pressure and flow.

    abstract::Diminished poststenotic pressure and flow accompanied experimental application of multiple subcritical arterial stenoses in series. Effects of additional stenoses, causing equivalent constrictions, were cumulative in a nonlinear fashion. Seven-hundred-twenty measurements were performed using 10 cm ileofemoral canine a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197711000-00020

    authors: Flanigan DP,Tullis JP,Streeter VL,Whitehouse WM Jr,Fry WJ,Stanley JC

    更新日期:1977-11-01 00:00:00

  • Hospital Volume of Antireflux Surgery in Relation to Endoscopic and Surgical Re-interventions.

    abstract:OBJECTIVE:To test the hypothesis that higher hospital volume decreases endoscopic and surgical re-intervention rates after antireflux surgery. BACKGROUND:Antireflux surgery for gastro-esophageal reflux disease is followed by varying rates of re-interventions. Whether hospital volume influences re-intervention rates is...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003776

    authors: Markar S,Santoni G,Maret-Ouda J,Artama M,Färkkilä M,Lynge E,Pukkala E,Ness-Jensen E,von Euler-Chelpin M,Lagergren J

    更新日期:2020-01-06 00:00:00

  • Surgical management of reflux strictures of the esophagus in childhood.

    abstract::The etiology of gastroesophageal reflux (GER) in infancy is related to developmental factors, and there is a high incidence of associated conditions such as neurologic syndromes and esophageal atresia (60%). This is different from the situation in adults. Experience with 18 consecutive children with peptic esophageal ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198210000-00008

    authors: O'Neill JA Jr,Betts J,Ziegler MM,Schnaufer L,Bishop HC,Templeton JM

    更新日期:1982-10-01 00:00:00

  • Reversal of mortality for congenital diaphragmatic hernia with ECMO.

    abstract::Extracorporeal Membrane Oxygenation (ECMO) has been available to neonates with respiratory failure at the University of Michigan School of Medicine since June 1981. In order to evaluate the impact of this type of pulmonary support, a retrospective analysis of 50 neonates with posterolateral congenital diaphragmatic he...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-198902000-00014

    authors: Heiss K,Manning P,Oldham KT,Coran AG,Polley TZ Jr,Wesley JR,Bartlett RH

    更新日期:1989-02-01 00:00:00

  • Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience.

    abstract:OBJECTIVE:The objective of the study was to achieve limb salvage in patients with locally advanced soft tissue sarcomas that can only be treated by amputation or functionally mutilating surgery by performing an isolated limb perfusion (ILP) with tumor necrosis factor (TNF) + melphalan (M) as induction biochemotherapy t...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/00000658-199612000-00011

    authors: Eggermont AM,Schraffordt Koops H,Klausner JM,Kroon BB,Schlag PM,Liénard D,van Geel AN,Hoekstra HJ,Meller I,Nieweg OE,Kettelhack C,Ben-Ari G,Pector JC,Lejeune FJ

    更新日期:1996-12-01 00:00:00

  • Lymph node retrieval during esophagectomy with and without neoadjuvant chemoradiotherapy: prognostic and therapeutic impact on survival.

    abstract:OBJECTIVES:We aimed to examine the association between total number of resected nodes and survival in patients after esophagectomy with and without nCRT. BACKGROUND:Most studies concerning the potentially positive effect of extended lymphadenectomy on survival have been performed in patients who underwent surgery alon...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000000965

    authors: Koen Talsma A,Shapiro J,Looman CW,van Hagen P,Steyerberg EW,van der Gaast A,van Berge Henegouwen MI,Wijnhoven BP,van Lanschot JJ,CROSS Study Group.,Hulshof MC,van Laarhoven HW,Nieuwenhuijzen GA,Hospers GA,Bonenkamp JJ,Cuest

    更新日期:2014-11-01 00:00:00

  • Intra-aortic balloon counterpulsation: potential for therapy in hemorrhagic shock with associated myocardial failure.

    abstract::After attaching appropriate monitoring devices enabling the measurement of the slope of the left ventricular function curve, left atrial pressure, mean aortic pressure, peak left ventricular pressure, and tension time index, three groups of ten dogs were subjected to varying periods of hemorrhagic shock until a slope ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197501000-00025

    authors: Proctor HJ,Hsiao H,Fry J,Ebert C

    更新日期:1975-01-01 00:00:00

  • Effect of intravenous hyperalimentation on established delayed hypersensitivity in the cancer patient.

    abstract::Forty-seven cancer patients were selected for study based on their candidacy for hyperalimentation. Each patient received selected skin test antigens intradermally in the forearm prior to the initiation of hyperalimentation, and at 7-day intervals throughout treatment with either chemotherapy, radiation therapy or sur...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197607000-00010

    authors: Copeland EM,Fadyen BV Jr,Dudrick SJ

    更新日期:1976-07-01 00:00:00

  • Interleukin 12 secretion enhances antitumor efficacy of oncolytic herpes simplex viral therapy for colorectal cancer.

    abstract:OBJECTIVE:To assess the strategy of combining oncolytic herpes simplex virus (HSV) therapy with immunomodulatory therapy as treatment for experimental colon cancer. The oncolytic HSV recombinant NV1023 and the interleukin 12 (IL-12)-secreting oncolytic NV1042 virus were evaluated in vitro and in vivo with respect to an...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200106000-00012

    authors: Bennett JJ,Malhotra S,Wong RJ,Delman K,Zager J,St-Louis M,Johnson P,Fong Y

    更新日期:2001-06-01 00:00:00

  • Appendectomy: a contemporary appraisal.

    abstract:OBJECTIVE:The authors present an accurate and comprehensive snapshot of appendicitis and the practice of appendectomy in the 1990s. METHODS:Appendectomies were performed on 4950 patients in 147 Department of Defense hospitals worldwide over a 12-month period ending January 31, 1993. RESULTS:The median age was 23 year...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-199703000-00003

    authors: Hale DA,Molloy M,Pearl RH,Schutt DC,Jaques DP

    更新日期:1997-03-01 00:00:00

  • Integrative marker analysis allows risk assessment for metastasis in stage II colon cancer.

    abstract:OBJECTIVES:Individualized risk assessment in patients with UICC stage II colon cancer based on a panel of molecular genetic alterations. BACKGROUND:Risk assessment in patients with colon cancer and localized disease (UICC stage II) is not sufficiently reliable. Development of metachronous metastasis is assumed to be g...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318272de87

    authors: Nitsche U,Rosenberg R,Balmert A,Schuster T,Slotta-Huspenina J,Herrmann P,Bader FG,Friess H,Schlag PM,Stein U,Janssen KP

    更新日期:2012-11-01 00:00:00

  • Sentinel node staging of resectable colon cancer: results of a multicenter study.

    abstract:OBJECTIVE AND SUMMARY BACKGROUND DATA:Sentinel lymph node (LN) sampling, a technique widely used to manage breast cancer and melanoma, seeks to select LNs that accurately predict regional node status and can be extensively examined to identify nodal metastatic disease not detected by standard histopathological staging....

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/01.sla.0000140753.41357.20

    authors: Bertagnolli M,Miedema B,Redston M,Dowell J,Niedzwiecki D,Fleshman J,Bem J,Mayer R,Zinner M,Compton C

    更新日期:2004-10-01 00:00:00

  • The effect of complications on length of stay.

    abstract:OBJECTIVES:The authors determined the effect of complications on length of stay (LOS) in surgical patients. SETTING:From 1987 to 1990, in the Professional General Surgical Unit of Royal Victoria Hospital, a retrospective survey was conducted on 5128 consecutively admitted patients with 396 different diagnosis; 228 dif...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199412000-00006

    authors: McAleese P,Odling-Smee W

    更新日期:1994-12-01 00:00:00

  • Submaximal exercise during intravenous hyperalimentation of depleted subjects.

    abstract::The peripheral nitrogen wasting and loss of functional capacity caused by the malnutrition of disease and the immobilization of hospitalization may not be readily reversed by refeeding alone. In order to examine submaximal exercise as an adjunctive anabolic stimulus to intravenous refeeding (IVF) in depleted subjects,...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-198803000-00012

    authors: Fong Y,Hesse DG,Tracey KJ,Albert JD,Legaspi A,Brennan MF,Lowry SF

    更新日期:1988-03-01 00:00:00

  • Motor function in the excluded esophagus and its implications in the management of patients with unresectable carcinoma of the esophagus.

    abstract::Palliative exclusion of the esophagus by use of transposed stomach was performed in a 63-year-old woman with unresectable cervical esophageal cancer. Twelve weeks after this operation, motor function of the excluded esophagus was assessed. All voluntary swallows produced a motor response in the esophageal body. Eighty...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198712000-00017

    authors: Duranceau AC,Lafontaine ER,Archambault SC,Jamieson GG

    更新日期:1987-12-01 00:00:00