Multiple subcritical arterial stenoses: effect on poststenotic pressure and flow.

Abstract:

:Diminished poststenotic pressure and flow accompanied experimental application of multiple subcritical arterial stenoses in series. Effects of additional stenoses, causing equivalent constrictions, were cumulative in a nonlinear fashion. Seven-hundred-twenty measurements were performed using 10 cm ileofemoral canine arterial segments in vitro and in vivo with pulsatile and nonpulsatile blood flow. Pressures and flow volumes utilized for testing were within normal physiologic ranges. Data analysis included correlations of experimental observations with predictions generated from a theoretic hydraulic model. Kinetic energy losses with multiple subcritical stenoses were associated with decreased pressure and flow. Poststenotic pressure decreased as much as 51% in some experiments. Diminutions in flow paralleled pressure changes. Measured pressure changes were nonlinear and followed mathematic predictions of appreciable but lesser effects of added stenoses. Hemodynamic alterations of magnitudes documented in this study assume clinical importance. The assumption that a solitary critical stenosis must exist before significant hemodynamic changes occur is no longer tenable.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Flanigan DP,Tullis JP,Streeter VL,Whitehouse WM Jr,Fry WJ,Stanley JC

doi

10.1097/00000658-197711000-00020

subject

Has Abstract

pub_date

1977-11-01 00:00:00

pages

663-8

issue

5

eissn

0003-4932

issn

1528-1140

journal_volume

186

pub_type

杂志文章
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    journal_title:Annals of surgery

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    更新日期:2014-07-01 00:00:00

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    authors: Girard RM,Legros G

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    更新日期:1988-03-01 00:00:00

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    authors: Jacob-Brassard J,Al-Omran M,Nathens AB,Forbes TL,de Mestral C

    更新日期:2020-09-01 00:00:00

  • The comparative effectiveness of surgeons over interventionalists in endovascular repairs of abdominal aortic aneurysm.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182a196b5

    authors: McCutcheon BA,Talamini MA,Chang DC,Rose JA,Bandyk DF,Wilson SE

    更新日期:2013-09-01 00:00:00

  • Antiviral Therapy Reduces Hepatocellular Carcinoma Recurrence in Patients With Low HBV-DNA Levels: A Randomized Controlled Trial.

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    pub_type: 杂志文章,随机对照试验

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    更新日期:2018-12-01 00:00:00

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    journal_title:Annals of surgery

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    更新日期:1996-09-01 00:00:00

  • Unique Tracheal Fluid MicroRNA Signature Predicts Response to FETO in Patients With Congenital Diaphragmatic Hernia.

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  • Surgical management of acute cholecystitis in patients 65 years of age and older.

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    pub_type: 杂志文章

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    pub_type: 临床试验,杂志文章

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    pub_type: 杂志文章,多中心研究,随机对照试验

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    更新日期:1980-03-01 00:00:00

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    authors: Räty S,Pulkkinen J,Nordback I,Sand J,Victorzon M,Grönroos J,Helminen H,Kuusanmäki P,Nordström P,Paajanen H

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