Abstract:
:Coagulation activity and whole-blood viscosity were measured in the steady state, and serially during painful crisis, in eight patients with sickle-cell anaemia. Platelet and coagulation activation occurred in the steady state and became more pronounced early in crisis. Whole-blood viscosity increased during crisis in parallel with plasma fibrinogen. Similar changes were found in a parallel study of 20 patients with localized bacterial or viral infection who did not have sickle-cell anaemia. Reports of platelet activation, hypercoagulability, and hyperviscosity during painful crisis therefore reflect secondary changes arising from vascular stasis, precipitating infection, and an acute-phase protein reaction. Although secondary, these changes may contribute to vascular occlusion by an additive effect in vessels already partially occluded by sickled cells.
journal_name
Br J Haematoljournal_title
British journal of haematologyauthors
Richardson SG,Matthews KB,Stuart J,Geddes AM,Wilcox RMdoi
10.1111/j.1365-2141.1979.tb03685.xsubject
Has Abstractpub_date
1979-01-01 00:00:00pages
95-103issue
1eissn
0007-1048issn
1365-2141journal_volume
41pub_type
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