Abstract:
:Obesity is a major risk factor for the development of asthma, and worsens the key features of asthma including airway hyperresponsiveness, inflammation, and airway remodeling. Although pro- and anti-inflammatory adipocytokines may contribute to the pathogenesis of asthma in obesity, the mechanistic basis for the relationship between asthma and obesity remains unclear. In obese individuals, the increased amount of adipose tissue results in the release of more long-chain free fatty acids as compared to lean individuals, causing an elevation in plasma long-chain free fatty acid concentrations. Recent findings suggest that the free fatty acid receptor 1 (FFAR1), which is a sensor of medium- and long-chain free fatty acids, is expressed on airway smooth muscle and plays a pivotal role in airway contraction and airway smooth muscle cell proliferation. In contrast, FFAR4, which is a sensor for long-chain n-3 polyunsaturated fatty acids and also expressed on airway smooth muscle, does not contribute to airway contraction and airway smooth muscle cell proliferation. Functional roles for short-chain fatty acid receptors FFAR2 and FFAR3 in the pathogenesis of asthma is still under debate. Taken together, adipose-derived long-chain free fatty acids may contribute to the pathogenesis of asthma in obesity through FFAR1.
journal_name
Jpn Dent Sci Revjournal_title
The Japanese dental science reviewauthors
Mizuta K,Matoba A,Shibata S,Masaki E,Emala CW Srdoi
10.1016/j.jdsr.2019.07.002keywords:
["Airway smooth muscle","Asthma","Free fatty acid receptor","Obesity"]subject
Has Abstractpub_date
2019-11-01 00:00:00pages
103-107issue
1eissn
1882-7616issn
2213-6851pii
S1882-7616(18)30019-Xjournal_volume
55pub_type
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