Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps.

Abstract:

:We have demonstrated previously that oxygen-derived free radicals are important mediators of tissue injury following ischemia (total venous occlusion) and reperfusion in small (3 cm X 6 cm) island skin flaps in rats. In this study, we evaluated extension of this concept to regional ischemia in large (8 cm X 8 cm) acute island skin flaps which were constructed to exceed their sole blood supply via unilateral inferior epigastric vessels. Under normal (control) circumstances, a significant portion of the flap would undergo necrosis at the periphery, mimicking the corresponding clinical situation. Blocking the generation of superoxide radicals from xanthine oxidase with a single dose of allopurinol prior to flap elevation significantly improved the area of flap viability from 34 +/- 12% to 57 +/- 6% (p less than 0.01) in the random portion of the flap, contralateral to the source of blood supply. Similarly, the detoxification of superoxide radicals with a single dose of superoxide dismutase improved viability from 41 +/- 6% to 58 +/- 7% (p less than 0.01). Similar results were obtained when either of these agents were administered 60 minutes after flap elevation. These findings suggest that oxygen-derived free radicals play an important role in the development of tissue necrosis in the critical transition zone between well-vascularized and devascularized skin.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Im MJ,Manson PN,Bulkley GB,Hoopes JE

doi

10.1097/00000658-198503000-00018

subject

Has Abstract

pub_date

1985-03-01 00:00:00

pages

357-9

issue

3

eissn

0003-4932

issn

1528-1140

journal_volume

201

pub_type

杂志文章
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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-199109000-00011

    authors: Berlauk JF,Abrams JH,Gilmour IJ,O'Connor SR,Knighton DR,Cerra FB

    更新日期:1991-09-01 00:00:00

  • Major hepatectomy for the treatment of complex bile duct injury.

    abstract:BACKGROUND:Postcholecystectomy complex bile duct injuries involving the hilar confluence, which are often associated with vascular injuries and liver atrophy, remain a considerable surgical challenge. The aim of this study is to report our experience of major hepatectomy with long-term outcome in these patients. METHO...

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    doi:10.1097/SLA.0b013e31817b65f2

    authors: Laurent A,Sauvanet A,Farges O,Watrin T,Rivkine E,Belghiti J

    更新日期:2008-07-01 00:00:00

  • Prerandomization Surgical Training for the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-32 trial: a randomized phase III clinical trial to compare sentinel node resection to conventional axillary dissection in clinically node-negative bre

    abstract:OBJECTIVE:To train surgeons in a standardized technique of sentinel lymph node biopsy and to prepare them for the requirements of a prospective randomized surgical trial. SUMMARY BACKGROUND DATA:The NSABP B32 trial opened to accrual in May 1999. A significant component of this trial was a prerandomization training pha...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Harlow SP,Krag DN,Julian TB,Ashikaga T,Weaver DL,Feldman SA,Klimberg VS,Kusminsky R,Moffat FL Jr,Noyes RD,Beitsch PD

    更新日期:2005-01-01 00:00:00

  • Influence of the postoperative state on the intracellular free amino acids in human muscle tissue.

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    pub_type: 杂志文章

    doi:10.1097/00000658-197512000-00001

    authors: Vinnars E,Bergstöm J,Fürst P

    更新日期:1975-12-01 00:00:00

  • Minimally invasive esophagectomy: outcomes in 222 patients.

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    journal_title:Annals of surgery

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    doi:10.1097/01.sla.0000089858.40725.68

    authors: Luketich JD,Alvelo-Rivera M,Buenaventura PO,Christie NA,McCaughan JS,Litle VR,Schauer PR,Close JM,Fernando HC

    更新日期:2003-10-01 00:00:00

  • Utility of Adjuvant Chemotherapy After Neoadjuvant Chemoradiation and Esophagectomy for Esophageal Cancer.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001954

    authors: Burt BM,Groth SS,Sada YH,Farjah F,Cornwell L,Sugarbaker DJ,Massarweh NN

    更新日期:2017-08-01 00:00:00

  • Case managers in mass casualty incidents.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31819a6f17

    authors: Einav S,Schecter WP,Matot I,Horn JK,Hersch M,Reissman P,Spira RM

    更新日期:2009-03-01 00:00:00

  • A Comparative Analysis of Survival and Funding Discrepancies in Cancers With High Mortality.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003042

    authors: Hall BR,Cannon A,Atri P,Wichman CS,Smith LM,Kumar S,Batra SK,Wang H,Ganti AK,Sasson AR,Are C

    更新日期:2020-02-01 00:00:00

  • Impact of Surgical Resection of the Primary Tumor on Overall Survival in Patients With Metastatic Pheochromocytoma or Sympathetic Paraganglioma.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002195

    authors: Roman-Gonzalez A,Zhou S,Ayala-Ramirez M,Shen C,Waguespack SG,Habra MA,Karam JA,Perrier N,Wood CG,Jimenez C

    更新日期:2018-07-01 00:00:00

  • Cholangitis with acute renal failure: priorities in therapeutics.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197506000-00022

    authors: Bismuth H,Kuntziger H,Corlette MB

    更新日期:1975-06-01 00:00:00

  • Intramuscular pressure in the lower leg in deep vein thrombosis and phlegmasia cerulae dolens.

    abstract::The influence of deep vein thrombosis on intramuscular pressure was evaluated in 22 patients by means of the wick technique. Intramuscular pressure was measured in the anterior tibial and the deep posterior compartments in both legs before and during treatment. The intramuscular pressure was significantly (p less than...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198304000-00013

    authors: Qvarfordt P,Eklöf B,Ohlin P

    更新日期:1983-04-01 00:00:00

  • Risk and location of cancer in patients with preoperative colitis-associated dysplasia undergoing proctocolectomy.

    abstract:OBJECTIVE:To evaluate the influence of preoperative dysplasia grade, appearance, and site on risk and location of cancer in patients with colitis. BACKGROUND:The ability to predict the presence and location of cancer in colitis patients with dysplasia is essential to facilitate recommendations regarding the necessity ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31828e7417

    authors: Kiran RP,Ahmed Ali U,Nisar PJ,Khoury W,Gu J,Shen B,Remzi FH,Hammel JP,Lavery IC,Fazio VW,Goldblum JR

    更新日期:2014-02-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200102000-00013

    authors: Lau WY,Leung TW,Lai BS,Liew CT,Ho SK,Yu SC,Tang AM

    更新日期:2001-02-01 00:00:00

  • Administration of balanced or BCAA-enriched amino acid solution in septic rats. Effects on protein synthesis in the liver.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198812000-00007

    authors: Pedersen P,Li SJ,Hasselgren PO,LaFrance R,Fischer JE

    更新日期:1988-12-01 00:00:00

  • Variceal recurrence, rebleeding, and survival after endoscopic injection sclerotherapy in 287 alcoholic cirrhotic patients with bleeding esophageal varices.

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    pub_type: 杂志文章

    doi:10.1097/01.sla.0000231704.45005.4e

    authors: Krige JE,Kotze UK,Bornman PC,Shaw JM,Klipin M

    更新日期:2006-11-01 00:00:00

  • Incidence and outcome of biliary strictures after pancreaticoduodenectomy.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000216285.07069.fc

    authors: House MG,Cameron JL,Schulick RD,Campbell KA,Sauter PK,Coleman J,Lillemoe KD,Yeo CJ

    更新日期:2006-05-01 00:00:00

  • Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200209000-00010

    authors: Delman KA,Zager JS,Bennett JJ,Malhotra S,Ebright MI,McAuliffe PF,Halterman MW,Federoff HJ,Fong Y

    更新日期:2002-09-01 00:00:00

  • Factors Associated With Recurrence and Survival in Lymph Node-negative Gastric Adenocarcinoma: A 7-Institution Study of the US Gastric Cancer Collaborative.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001084

    authors: Jin LX,Moses LE,Squires MH 3rd,Poultsides GA,Votanopoulos K,Weber SM,Bloomston M,Pawlik TM,Hawkins WG,Linehan DC,Strasberg SM,Schmidt C,Worhunsky DJ,Acher AW,Cardona K,Cho CS,Kooby DA,Levine E,Winslow ER,Saunders ND

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  • Sensitivity of the canine pancreatic intraductal pressure to subclinical reduction in cholinesterase acitivity.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197907000-00002

    authors: Dressel TD,Goodale RL Jr,Hunninghake DB,Borner JW

    更新日期:1979-07-01 00:00:00

  • A randomized trial comparing radiofrequency ablation and surgical resection for HCC conforming to the Milan criteria.

    abstract:OBJECTIVE:To compare the long-term outcomes of surgical resection and radiofrequency ablation for the treatment of small hepatocellular carcinoma (HCC). SUMMARY BACKGROUND DATA:Radiofrequency ablation (RFA) is a promising, emerging therapy for small HCC. Whether it is as effective as surgical resection (RES) for long-...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e3181efc656

    authors: Huang J,Yan L,Cheng Z,Wu H,Du L,Wang J,Xu Y,Zeng Y

    更新日期:2010-12-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197707000-00015

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    更新日期:1977-07-01 00:00:00

  • Recurrent carotid stenosis. A five-year series of 65 reoperations.

    abstract::From 1979 to 1983, 1726 carotid endarterectomies were performed at the Cleveland Clinic. During this period, 39 men (mean age, 60 years) and 22 women (mean age, 63 years) required 65 reoperations (3.8%) for correction of recurrent carotid stenosis occurring 3 to 194 months (mean, 42 months) after previous endarterecto...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198507000-00004

    authors: Das MB,Hertzer NR,Ratliff NB,O'Hara PJ,Beven EG

    更新日期:1985-07-01 00:00:00

  • Infrarenal abdominal aortic aneurysm: factors influencing survival after operation performed over a 25-year period.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198106000-00005

    authors: Crawford ES,Saleh SA,Babb JW 3rd,Glaeser DH,Vaccaro PS,Silvers A

    更新日期:1981-06-01 00:00:00

  • Comparison of a lymph node ratio-based staging system with the 7th AJCC system for gastric cancer: analysis of 18,043 patients from the SEER database.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1097/00000658-200106000-00012

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1097/00000658-200110000-00006

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    authors: Morton RP,Levitt MR,Emerson S,Ghodke BV,Hallam DK,Sekhar LN,Kim LJ,Chesnut RM

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    更新日期:1981-10-01 00:00:00