Risk factors for the development of atherosclerosis in childhood and adolescence.

Abstract:

:Cardiovascular diseases (CVD) are a major cause of death in developed countries as well as in developing countries. In general, the clinical manifestations of CVD, such as myocardial infarction, stroke and peripheral vascular disease, are caused by an atherosclerotic process with onset as from the middle age. However, current studies indicate that the atherosclerotic process starts to develop in childhood. The pathogenesis of atherosclerosis has been studied as to its inflammatory aspect. Among the inflammatory markers, C-reactive protein (CRP) has been extensively studied in individuals with CVD, including those apparently healthy. High CRP levels have been related to risk factors for atherosclerosis: family history of coronary artery disease (CAD), dyslipidemia, hypertension, diabetes mellitus, obesity, smoking and sedentary lifestyle. A great part of these risk factors may be influenced by lifestyle modifications, such as changes in eating habits and engagement in physical activities. The effects of physical activity on CRP levels in adulthood are documented in the literature, however little is known on the influence of an active or sedentary lifestyle of children and adolescents on CRP levels. Thus, the objective of this study is to review the impact of physical activity of children and adolescents on CRP levels and the risk factors for the development of CVD.

journal_name

Arq Bras Cardiol

authors

Santos MG,Pegoraro M,Sandrini F,Macuco EC

doi

10.1590/s0066-782x2008000400012

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

276-283

issue

4

eissn

0066-782X

issn

1678-4170

pii

S0066-782X2008000400012

journal_volume

90

pub_type

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