Metabolic and blood catecholamine responses to exercise during alkalosis.

Abstract:

:The effects of metabolic alkalosis on muscle lactate accumulation and plasma catecholamine concentrations were studied in six highly trained subjects during short-term ergocycle exercises to exhaustion (375 W). The studies were performed after oral administration of NaHCO3 (alkalosis) and CaCO3 (placebo). There was a significant increase in resting blood pH after NaHCO3 ingestion (7.35 +/- 0.02) compared to placebo (7.27 +/- 0.02). A longer endurance time was achieved during alkalosis (75.3 +/- 8 s) than during control (61.5 +/- 2 s), but similar blood pH and HCO3- levels were found at exhaustion in both treatments. Metabolic alkalosis resulted in higher elevation in muscle lactate concentration (31.7 +/- 4.6 mmol.kg-1 wet weight) compared to control (17 +/- 4 mmol.kg-1 wet weight). Despite longer exercise duration in alkalosis, plasma norepinephrine and epinephrine concentrations at exhaustion were reduced by 30 and 34%, respectively. These results indicate that alkalosis increased muscle lactate accumulation during exhaustive exercise. These changes were associated with a reduced blood catecholamine response to exercise.

journal_name

Med Sci Sports Exerc

authors

Bouissou P,Defer G,Guezennec CY,Estrade PY,Serrurier B

doi

10.1249/00005768-198806000-00003

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

228-32

issue

3

eissn

0195-9131

issn

1530-0315

journal_volume

20

pub_type

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