Abstract：
:A comparison was made between several characteristics of tissue-type plasminogen activator (t-PA) and urokinase (UK), potentially useful in microsurgery to restore perfusion to ischemic free-tissue transfers. An intraarterial infusion of one of the drugs (or normal saline [NS] as a control) was performed in conjunction with a rat femoral vein clot model. Both t-PA and urokinase were effective in lysing 100 percent of the venous clots on the side of infusion. This occurred in only 25 percent of controls (p = .0035). Thrombolysis on the contralateral side, a measure of systemic effect, occurred in 38 percent, 50 percent, and 13 percent of veins using t-PA, UK, and NS, respectively (t-PA vs. UK p = 1.0, t-PA vs. NS p = .28, UK vs. NS p = .14). Rethrombosis occurred in 13 percent and 25 percent of ipsilateral veins treated with t-PA and urokinase, respectively, and in one of the two veins that had resumed flow during saline infusion (t-PA vs. UK p = .30) Scanning electron microscopy was performed 4 hr and 48 hr after thrombolysis. No differences between thrombolytic agents was noted in terms of residual thrombus and vessel characteristics. The data suggest that t-PA and urokinase are effective, with no clear advantage of one agent over the other.
journal_name
J Reconstr Microsurgjournal_title
Journal of reconstructive microsurgeryauthors
Levy EA,Sadove AM,Eppley BL,Evan APdoi
10.1055/s-2007-1006781subject
Has Abstractpub_date
1991-07-01 00:00:00pages
209-16issue
3eissn
0743-684Xissn
1098-8947journal_volume
7pub_type
杂志文章abstract：:The use of nerve conduits has evolved from a previous experimental idea to a clinical reality over the last ten years. An overview of the literature on the clinical use of nerve conduits in peripheral-nerve repair is presented. ...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章,评审
doi：10.1055/s-2002-19889
更新日期：2002-02-01 00:00:00
abstract：:Reconstruction of defects or wounds of the distal third of the leg with exposed bone, tendon, or hardware is challenging. Free tissue transfer has allowed limb salvage in many cases but requires a relatively healthy and stable patient, long operative times, and a significant expense. Small and moderate-size wounds of ...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章,评审
doi：10.1055/s-0029-1223847
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND: Various reports suggest the augmentation of venous drainage through performing two venous anastomoses as a means of reducing the rate of thrombosis in free flap surgery. However, some suggest dual venous drainage may actually reduce venous blood flow velocity causing a potential risk for thrombosis. METHOD...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1055/s-0034-1372368
更新日期：2014-07-01 00:00:00
abstract：:Shoulder pathology and its diagnosis must be considered in evaluation of the patient suspected of having thoracic outlet syndrome (TOS). Overlooking usually treatable conditions in the shoulder may lead to unfavorable results, if treatment is directed, instead, to neurolysis of the brachial plexus or first rib resecti...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-2007-1006714
更新日期：1992-07-01 00:00:00
abstract：:Twenty-eight vascularized toe-joint transfers performed on 25 patients were reviewed. A number of different techniques were used: proximal interphalangeal joint or metacarpophalangeal joint reconstruction, one-stage double joint transfer, and interphalangeal thumb or trapezometacarpal joint replacement. Using these ty...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-2007-1006819
更新日期：1990-07-01 00:00:00
abstract：:Microsurgical reconstruction of the face completely destroyed after malignant skin tumor excisions in a xeroderma pigmentosum patient is reported. The patient's left cheek was reconstructed using a free latissimus dorsi flap and the nose using a free forearm flap with a base of iliac bone graft. There has been no recu...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-2007-1006812
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND: The superficial circumflex iliac artery (SCIA)-based iliac bone flap has yet to be widely used. The purpose of this article is to validate the feasibility of SCIA-based iliac bone flap transfers for reconstruction of small to moderate-sized bony defects. Retrospective outcome comparisons between SCIA-based ...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-0038-1651489
更新日期：2018-11-01 00:00:00
abstract：:A seven-year-old-boy received a digit replantation after 26 hours of warm ischemia and showed good recovery of motor and sensory functions. In the case reported, replantation was performed after a much longer ischemic time than had been considered an indication for the procedure in previous reports. Successful replant...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-2007-1006977
更新日期：1987-01-01 00:00:00
abstract：:The authors recently reported an experimental study on diode laser-assisted microvascular anastomosis (LAMA) in the femoral arteries and veins of rats. Good success rates and very promising histologic results obtained in this preliminary phase suggested an extension of the investigation with a larger number of rats an...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-2007-1006405
更新日期：1997-04-01 00:00:00
abstract：:The authors' experience indicates that good functional results are achievable in cases with wide resection of the knee extensor mechanism. They report a low-grade myxoid fibrosarcoma patient in whom a one-stage functional reconstruction was carried out by transfer of a free latissimus dorsi flap without secondary surg...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-2005-871749
更新日期：2005-05-01 00:00:00
abstract：BACKGROUND:Lymphedema leads to early deposition of adipose tissue. This may explain why conservative therapies such as complex decongestive therapy (CDT) and controlled compression therapy (CCT), as well as various forms of microsurgical reconstructions, cannot completely remove the excess volume in patients with a lar...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章,评审
doi：10.1055/s-0035-1549158
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND: The volume of the profunda femoris artery perforator (PAP) flap limits its indications to small- and medium-sized breast reconstructions after modified radical mastectomy for cancer. We report a modified PAP flap design, including not only a vertical extension that increases its volume but also the skin sur...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-0038-1649508
更新日期：2019-01-01 00:00:00
abstract：:Apolipoprotein E (apo E) is thought to mediate the reutilization of myelin cholesterol for nerve regeneration. Prior research suggests that apo E is not essential for nerve regeneration following a nerve crush injury. This study was conducted to determine if apo E is essential for nerve regeneration after nerve transe...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-2002-33321
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND: Replantation of a single digit at the distal phalanx level is not routinely performed since it is technically challenging with questionable cost-effectiveness. The purpose of this study was to analyze international microsurgeons' clinical decisions when faced with this common scenario. METHODS: A survey of...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-0039-1701013
更新日期：2020-05-01 00:00:00
abstract：:The anatomy of the ascending branch of the deep circumflex iliac vessels is reported. This vasculature allows the design of a musculoperitoneal flap, not exceeding 7 cm x 14 cm, together with an osteomusculocutaneous groin flap. The procedure is particularly useful, if resection of an intraoral carcinoma has included ...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-2007-1006848
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:The anterolateral thigh (ALT) flap has been widely used in reconstruction of soft tissue defects. The anatomic variations of perforators increase the difficulties of flap elevation. The ABC system has been described for locating the most common three perforators in Western populations. Less evidence has been...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-0033-1343496
更新日期：2013-06-01 00:00:00
abstract：:The authors conducted a two-part study to determine whether transcutaneous oxygen pressure (TcPO (2)) and transcutaneous carbon dioxide pressure (TcPCO (2)) can be used to monitor flap viability after transplantation. The first part was an animal study in which TcPO (2) and TcPCO (2) were measured in 10 epigastric isl...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-2007-985208
更新日期：2007-07-01 00:00:00
abstract：:Background Topical vasodilators are frequently used during free tissue transfer to prevent and treat vasospasm and microvascular thrombosis. A variety of agents have been studied and are available, yet most microsurgeons select an agent based on anecdotal evidence or personal training. Our aim was to review the litera...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章,评审
doi：10.1055/s-0036-1592191
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:The authors presented their clinical experience and demonstrated surgical methods for reconstructing complex bone and soft tissue defects of the hand by using modified chimeric radial collateral artery perforator flaps. METHODS:Surgical procedures that employed 16 modified chimeric radial collateral artery ...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-0034-1390324
更新日期：2015-03-01 00:00:00
abstract：:The dorsalis pedis fasciocutaneous flap has been used successfully in soft tissue reconstruction both as a pedicled and a free flap. The long-term donor site problems associated with this dorsalis pedis flap prompted us to look at the use of the dorsalis pedis fascial flap in soft tissue reconstruction. We describe th...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-0029-1215541
更新日期：2009-06-01 00:00:00
abstract：:The authors' experiences with 34 free lower TRAM flap transfers, in which 19 primary reconstructions and 15 secondary reconstructions were successfully achieved, are reviewed. The free TRAM flap yielded better results than the pedicled TRAM flap in cases where reconstruction of the infraclavicular and anterior axillar...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-2007-1006676
更新日期：1992-01-01 00:00:00
abstract：:Although the lateral thigh flap has been well described as a fasciocutaneous flap based on one or more of the four perforators of the profunda femoris artery, the role for these individual perforators as perforator flaps has not been described. These profunda femoris artery perforators offer a particularly useful opti...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-0031-1275494
更新日期：2011-05-01 00:00:00
abstract：:Multilayered tubes fabricated from human amnion were placed subcutaneously and/or longitudinally in contact with an axial artery and vein in rats. Histologic evaluation at the third postoperative week showed that the tubes had incorporated with the surrounding fibrovascular tissue. New capillary formation within the t...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-2007-1006749
更新日期：1993-11-01 00:00:00
abstract：:Considerable controversy persists regarding the optimal technique for hypopharyngeal reconstruction. The ideal procedure should provide low mortality and morbidity, short hospitalization, a high success rate, few complications, and the greatest potential for neopharyngeal speech and deglutition. In this study, a varie...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-2002-19702
更新日期：2002-01-01 00:00:00
abstract：:Successful reconstruction of diabetic ulcers using free flap surgery can prevent further amputation and promote limb salvage to maintain normal gait of the patient and increase the quality of life after surgery. To minimize the postoperative complication and days of stay in hospital, surgeons should thoroughly investi...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-0040-1714431
更新日期：2021-01-01 00:00:00
abstract：:The effect of slow-release basic fibroblast growth factor (bFGF) on ischemia-reperfusion injury was examined using an island skin flap model in rats. Paired rectangular island skin flaps were elevated on the dorsum of 30 Fischer rats. The flaps were subjected to 6 hours of ischemia. Before reperfusion the flaps were i...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-0033-1343830
更新日期：2013-06-01 00:00:00
abstract：:This is the first in a series of studies designed to investigate the simultaneous changes in blood flow and microcirculation in an island flap during ischemia, in an ischemia-reperfusion model in the rabbit. An island groin flap based on the inferior epigastric vessels was harvested in 17 rabbits. The flap was rendere...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-2007-1006414
更新日期：1997-07-01 00:00:00
abstract：:Microvascular clamps have several potential shortcomings, including the risk of vessel injury. LeGoo, a novel reverse thermosensitive polymer (Pluromed Inc., Woburn, MA), is investigated as a substitute to vascular clamping in a microsurgical model and the technical details are described. Femoral vessels of Sprague Da...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-0028-1104556
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND: Unfractionated heparin has anticoagulant properties by catalyzing antithrombin III, which inactivates coagulation enzymes. Used in microsurgery, it would prevent the occurrence of thrombosis during microsurgical anastomoses. The objective of this study was to evaluate the role of intraoperative irrigation o...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-0039-1694723
更新日期：2020-01-01 00:00:00
abstract：:The free extended lateral arm flap (ELAF) has gained increasing popularity thank to its slimness and versatility, longer neurovascular pedicle, and greater flap size when compared with the original flap design. The aim of this study was to assess the donor-site morbidity associated with this extended procedure. A retr...
journal_title：Journal of reconstructive microsurgery
pub_type： 杂志文章
doi：10.1055/s-0031-1289165
更新日期：2012-02-01 00:00:00
