Treatment of a potentially lethal dose isoniazid ingestion.

Abstract:

:A seven-year-old boy ingested 3,000 mg (125 mg/kg) of isoniazid. Initial blood levels of isoniazid were 250 micrograms/mL approximately six hours after ingestion. Despite IV treatment in the emergency department with 3,000 mg pyridoxine and a repeat of the same antidote one hour later in the intensive care unit, the high isoniazid blood levels and persistent metabolic acidosis and coma prompted a decision to increase drug clearance by hemodialysis. Clearance data confirmed the effectiveness of hemodialysis in removing the poison, and the clinical response was dramatic.

journal_name

Ann Emerg Med

authors

Orlowski JP,Paganini EP,Pippenger CE

doi

10.1016/s0196-0644(88)80509-2

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

73-6

issue

1

eissn

0196-0644

issn

1097-6760

pii

S0196-0644(88)80509-2

journal_volume

17

pub_type

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