Recurrence and malignant degeneration after resection of adult hemispheric low-grade gliomas.

Abstract:

OBJECT:Unlike their malignant counterparts, low-grade gliomas are associated with prolonged survival. However, these tumors have a propensity to progress after resection and ultimately undergo malignant degeneration. The factors associated with recurrence and malignant degeneration remain relatively unknown. The authors set out to determine factors that were independently associated with recurrence and malignant degeneration in patients who underwent resection of a hemispheric low-grade glioma. METHODS:Adult patients who underwent craniotomy and resection of a hemispheric low-grade glioma (WHO Grade II) at the Johns Hopkins Medical Institution's academic tertiary-care institution between 1996 and 2006 were retrospectively reviewed. Multivariate proportional hazards regression analyses were used to identify associations with tumor recurrence and malignant degeneration. RESULTS:Of the 191 consecutive patients with low-grade gliomas in this series (89 fibrillary astrocytomas, 89 oligodendrogliomas, and 13 mixed gliomas), 83 (43%) and 44 (23%) experienced tumor recurrence and malignant degeneration at last follow-up, respectively. The 5-year progression-free and malignancy-free survival rates were 44 and 74%, respectively. Independent predictors of recurrence were duration of longest lasting symptom (relative risk [RR] 0.978, 95% CI 0.954-0.996, p = 0.01), tumor size (RR 1.328, 95% CI 1.109-1.602, p = 0.002), and preoperative contrast enhancement (RR 2.558, 95% CI 1.241-5.021, p = 0.01). Independent factors associated with malignant degeneration were fibrillary astrocytoma pathology (RR 1.800, 95% CI 1.008-4.928, p = 0.04), tumor size (RR 1.086, 95% CI 1.044-1.358, p = 0.04), and gross-total resection (RR 0.526, 95% CI 0.221-1.007, p = 0.05). CONCLUSIONS:The identification and consideration of factors associated with recurrence and malignant progression may help guide treatment strategies aimed at delaying recurrence and preventing malignant degeneration for patients with hemispheric low-grade gliomas.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Chaichana KL,McGirt MJ,Laterra J,Olivi A,Quiñones-Hinojosa A

doi

10.3171/2008.10.JNS08608

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

10-7

issue

1

eissn

0022-3085

issn

1933-0693

journal_volume

112

pub_type

杂志文章
  • Bilateral open-door cervical expansive laminoplasty with hydroxyapatite spacers and titanium screws.

    abstract:OBJECT:The authors report a simple method for bilateral open-door cervical expansive laminoplasty in which hydroxyapatite (HA) spacers are secured by titanium screws. A biomechanical study was also conducted to confirm the strength of the screw fixation. METHODS:A unilateral posterior approach was used to allow preser...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2002.96.1.0022

    authors: Takayasu M,Takagi T,Nishizawa T,Osuka K,Nakajima T,Yoshida J

    更新日期:2002-01-01 00:00:00

  • Indwelling double-balloon shunt for carotid endarterectomy. Technical note.

    abstract::The authors describe an indwelling intraluminal shunt for carotid endarterectomy. The device is equipped with balloons at both ends to prevent bleeding and to hold the tube in place. The design permits use of a small tube which facilitates insertion, and prevents intimal damage and limitation of exposure of arterial p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.4.0861

    authors: Furui T,Hasuo M

    更新日期:1984-04-01 00:00:00

  • The first formulation of image-based stereotactic principles: the forgotten work of Gaston Contremoulins.

    abstract::Although image-based human stereotaxis began with Spiegel and Wycis in 1947, the major principles of radiographic stereotaxis were formulated 50 years earlier by the French scientific photographer Gaston Contremoulins. In 1897, frustrated by the high morbidity of bullet extraction from the brain, the Parisian surgeon ...

    journal_title:Journal of neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.3171/2016.10.JNS161966

    authors: Giller CA,Mornet P,Moreau JF

    更新日期:2017-12-01 00:00:00

  • Burden of cerebral hypoperfusion in patients with delayed cerebral ischemia after subarachnoid hemorrhage.

    abstract:OBJECTIVE:Delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) may result in focal neurological deficits and cerebral infarction, believed to result from critical regional rather than global impairments in cerebral blood flow (CBF). However, the burden of such regional hypoperfusion has not been evaluate...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2019.3.JNS183041

    authors: Jafri H,Diringer MN,Allen M,Zazulia AR,Zipfel GJ,Dhar R

    更新日期:2019-05-31 00:00:00

  • Aneurysm-related subarachnoid hemorrhage and acute subdural hematoma: single-center series and systematic review.

    abstract:OBJECT:Subarachnoid hemorrhage (SAH) with simultaneous acute subdural hematoma (SDH) is a severe disease. The authors' objective was to analyze the incidence, prognosis, and clinical outcome of patients suffering from aneurysm-related SAH and space-occupying acute SDH. METHODS:Between June 1999 and June 2011, data fro...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/2012.11.JNS121435

    authors: Schuss P,Konczalla J,Platz J,Vatter H,Seifert V,Güresir E

    更新日期:2013-05-01 00:00:00

  • Extradural lipomatosis simulating an acute herniated nucleus pulposus. Case report.

    abstract::A 48-year-old laborer presented with a 1-year history of low-back pain radiating into the posterior aspects of both thighs. Two weeks before admission, acute exacerbation resulted in signs and symptoms of compressive radiculopathy at L-5. Myelography revealed concentric constriction of the lower thecal sac due to abun...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1982.57.4.0559

    authors: Archer CR,Smith KR Jr

    更新日期:1982-10-01 00:00:00

  • Cerebellar stimulation in man. Quantitative changes in spasticity.

    abstract::The effects of chronic anterior lobe cerebellar stimulation on patients with cerebral palsy have been investigated using a new method of quanitfying muscle rigidity and stretch reflexes. The ankle is oscillated sinusoidally, compliance is measured at several frequencies, and electromyographic activity of the extensor ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.48.5.0779

    authors: Penn RD,Gottlieb GL,Agarwal GC

    更新日期:1978-05-01 00:00:00

  • Dorsal root entry zone lesions for intractable pain after trauma to the conus medullaris and cauda equina.

    abstract::This review was undertaken to determine the efficacy of using dorsal root entry zone (DREZ) lesions to treat intractable pain caused by trauma to the conus medullaris and cauda equina. Traumatic lesions of this area are unique in that both the spinal cord and the peripheral nerve roots are injured. Although DREZ lesio...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.82.1.0028

    authors: Sampson JH,Cashman RE,Nashold BS Jr,Friedman AH

    更新日期:1995-01-01 00:00:00

  • Longitudinal survey of cranial case log entries during neurological surgery residency training.

    abstract::OBJECTIVEThe purpose of this study was to analyze national trends in adult cranial cases performed by neurological surgery residents as logged into the Accreditation Council for Graduate Medical Education (ACGME) system.METHODSThe ACGME resident case logs were retrospectively reviewed for the years 2009-2017. In these...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.2.JNS172734

    authors: Agarwal N,White MD,Cohen J,Lunsford LD,Hamilton DK

    更新日期:2018-07-01 00:00:00

  • Combining endovascular and neurosurgical treatments of high-risk dural arteriovenous fistulas in the lateral sinus and the confluence of the sinuses.

    abstract:OBJECT:The authors describe the use of a systemic approach to treat dural arteriovenous fistulas (DAVFs) in the lateral sinus and the confluence of sinuses in 17 patients who presented with signs and symptoms related to intracranial hemorrhage, infarction, and diffuse brain swelling. METHODS:Angiographic examination r...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.90.2.0289

    authors: Goto K,Sidipratomo P,Ogata N,Inoue T,Matsuno H

    更新日期:1999-02-01 00:00:00

  • Spontaneous decompression of syringomyelia: magnetic resonance imaging findings. Case report.

    abstract::The case of a 30-year-old woman with Chiari I malformation and a cervicothoracic syrinx is presented. The patient was followed clinically over a 2 1/2-year period. Spontaneous and complete resolution of the syrinx, as documented by serial magnetic resonance studies, was accompanied by only a minimal change in objectiv...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1991.74.2.0283

    authors: Jack CR Jr,Kokmen E,Onofrio BM

    更新日期:1991-02-01 00:00:00

  • Cerebral tissue PO2 and SjvO2 changes during moderate hyperventilation in patients with severe traumatic brain injury.

    abstract:OBJECT:The aim of this study was to investigate the effects of moderate hyperventilation on intracranial pressure (ICP), jugular venous oxygen saturation ([SjvO2], an index of global cerebral perfusion), and brain tissue PO2 (an index of local cerebral perfusion). METHODS:Ninety-four tests consisting of 20-minute peri...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2002.96.1.0097

    authors: Imberti R,Bellinzona G,Langer M

    更新日期:2002-01-01 00:00:00

  • Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases.

    abstract:OBJECT:The goal of this study was to investigate the protective effects of long-term (3-14 days) mild hypothermia therapy (33-35 degrees C) on outcome in 87 patients with severe traumatic brain injury (TBI) (Glasgow Coma Scale score < or = 8). METHODS:In 43 patients assigned to a mild hypothermia group, body temperatu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.93.4.0546

    authors: Jiang J,Yu M,Zhu C

    更新日期:2000-10-01 00:00:00

  • Control of growth of vestibular schwannomas with low-dose Gamma Knife surgery.

    abstract:OBJECT:The treatment of solitary vestibular schwannomas by performing Gamma Knife surgery is well established. It has been reported that decreasing the surface dose reduces patient morbidity, especially facial weakness and numbness. The authors of this retrospective study examine patient data from a single center to de...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/sup.2006.105.7.154

    authors: Hudgins WR,Antes KJ,Herbert MA,Weiner RL,DeSaloms JM,Stamos D,Barker JL,Echt GA,Nichols TD,Schwarz DE

    更新日期:2006-12-01 00:00:00

  • Efficacy of and morbidity associated with stereoelectroencephalography using computerized tomography--or magnetic resonance imaging-guided electrode implantation.

    abstract:OBJECT:The purpose of this paper was to define the general efficacy of and morbidity associated with stereoelectroencephalography using modem methods of imaging and to particularize the risks related to specific lobes of the brain. METHODS:All patients admitted to the Montreal Neurological Institute who had undergone ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2006.104.4.483

    authors: De Almeida AN,Olivier A,Quesney F,Dubeau F,Savard G,Andermann F

    更新日期:2006-04-01 00:00:00

  • Clinical significance of the flow gap in carotid magnetic resonance angiography.

    abstract::Magnetic resonance (MR) angiography offers a safe, noninvasive alternative to conventional angiography in patients with suspected carotid stenosis; however, it tends to overestimate the severity of stenosis. Loss of the MR signal with a resulting flow gap is a frequent finding in cases of high-grade stenosis. The auth...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.85.3.0384

    authors: Heiserman JE,Zabramski JM,Drayer BP,Keller PJ

    更新日期:1996-09-01 00:00:00

  • Local distribution and toxicity of prolonged hippocampal infusion of muscimol.

    abstract:OBJECT:The activity of gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter, is reduced in the hippocampus in patients with complex partial seizures from mesial temporal sclerosis. To provide preliminary safety and distribution data on using convection-enhanced delivery of agents to treat complex p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.103.6.1035

    authors: Heiss JD,Walbridge S,Morrison P,Hampton RR,Sato S,Vortmeyer A,Butman JA,O'Malley J,Vidwan P,Dedrick RL,Oldfield EH

    更新日期:2005-12-01 00:00:00

  • Painful supernumerary phantom arm following motor cortex stimulation for central poststroke pain. Case report.

    abstract::In this report, the authors describe a case in which the patient began to experience a supernumerary phantom arm after she received motor cortex stimulation for central pain. The patient had a history of right thalamocapsular stroke. It is speculated that the motor cortex activation triggered a response in the patient...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.91.1.0121

    authors: Canavero S,Bonicalzi V,Castellano G,Perozzo P,Massa-Micon B

    更新日期:1999-07-01 00:00:00

  • In-hospital mortality and length of hospital stay with craniotomy versus craniectomy for acute subdural hemorrhage: a multicenter, propensity score-matched analysis.

    abstract:OBJECTIVE:The optimal surgical treatment for acute subdural hemorrhage (ASDH) remains controversial. The purpose of this study was to compare outcomes in patients who underwent craniotomy with those in patients who underwent decompressive craniectomy for the treatment of ASDH. METHODS:Using the Japan Trauma Data Bank,...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2019.4.JNS182660

    authors: Shibahashi K,Sugiyama K,Tomio J,Hoda H,Morita A

    更新日期:2019-06-21 00:00:00

  • Intradural extramedullary tuberculoma of the cervical spine. Case report.

    abstract::A case is reported of a 45-year-old man who developed quadriplegia following a trivial motor-vehicle accident. Investigation including computerized tomography (CT) of the cervical spine revealed a large calcified lesion displacing the spinal cord and nerve roots, which proved to be a tuberculoma. The case is unusual i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.1.0200

    authors: Compton JS,Dorsch NW

    更新日期:1984-01-01 00:00:00

  • Mechanics of acute subdural hematomas resulting from bridging vein rupture.

    abstract:OBJECT:Based on data from primate experiments it is known that rotational acceleration in the sagittal plane and in a forward direction is most likely to produce acute subdural hematomas due to bridging vein rupture. For protection against these lesions, knowledge of rotational acceleration tolerance levels in humans i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2006.104.6.950

    authors: Depreitere B,Van Lierde C,Sloten JV,Van Audekercke R,Van der Perre G,Plets C,Goffin J

    更新日期:2006-06-01 00:00:00

  • W. James Gardner: pioneer neurosurgeon and inventor.

    abstract::W. James Gardner, a skillful neurosurgeon and inventor, is best remembered for his cervical tongs and hydrodynamic theory of syringomyelia. A pioneer of modern neurosurgery, Gardner trained under Charles Frazier in Philadelphia, and in 1929 he moved to Ohio where he became chief of neurosurgery at the Cleveland Clinic...

    journal_title:Journal of neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.3171/jns.2004.100.5.0965

    authors: Nathoo N,Mayberg MR,Barnett GH

    更新日期:2004-05-01 00:00:00

  • Prognostic value of diffusion tensor imaging parameters for Gamma Knife radiosurgery in meningiomas.

    abstract::OBJECTIVE Diffusion tensor imaging (DTI) parameters are able to differentiate between meningioma subtypes. The hypothesis that there is a correlation between DTI parameters and the change in tumor size after Gamma Knife radiosurgery (GKRS) was analyzed. METHODS DTI parameters were measured using MRI before GKRS in 26 ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.7.GKS161455

    authors: Speckter H,Bido J,Hernandez G,Mejía DR,Suazo L,Valenzuela S,Perez-Then E,Stoeter P

    更新日期:2016-12-01 00:00:00

  • Intracranial neurothekeoma (nerve-sheath myxoma). Case report.

    abstract::Neurothekeoma is a benign cutaneous nerve-sheath tumor. The authors describe the case of a 16-year-old girl with a parasellar neurothekeoma that was successfully removed. Magnetic resonance imaging with gadolinium administration revealed bright enhancement of the peripheral portions and nonhomogeneous uptake in the ce...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1993.79.2.0280

    authors: Paulus W,Warmuth-Metz M,Sörensen N

    更新日期:1993-08-01 00:00:00

  • Alterations in ventricular size and intracranial pressure caused by sagittal sinus pathology in man.

    abstract::Lumbar cerebrospinal fluid (CSF) pressure and ventricular size were determined in six patients with impairment of cerebral venous outflow caused by either sagittal sinus thrombosis or arteriovenous shunting into the sagittal sinus. None of the patients had enlargement of the ventricular system, but all six had elevate...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1980.53.5.0656

    authors: d'Avella D,Greenberg RP,Mingrino S,Scanarini M,Pardatscher K

    更新日期:1980-11-01 00:00:00

  • Results of nerve grafting in radial nerve injuries occurring proximal to the humerus, including those within the posterior cord.

    abstract::OBJECTIVE Results of radial nerve grafting are largely unknown for lesions of the radial nerve that occur proximal to the humerus, including those within the posterior cord. METHODS The authors describe 13 patients with proximal radial nerve injuries who were surgically treated and then followed for at least 24 months...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.12.JNS141944.test

    authors: Bertelli JA,Ghizoni MF

    更新日期:2016-01-01 00:00:00

  • Racial phenotypes in moyamoya disease: a comparative analysis of clinical presentation and natural history in a single multiethnic cohort of 250 hemispheres.

    abstract:OBJECTIVE:The authors aimed to determine whether differences exist in presentation and natural history when comparing Asian patients with moyamoya disease (MMD) to those of other ethnicities in North America. METHODS:A database of 137 patients with MMD presenting to their institution between 1994 and 2015 was reviewed...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2019.7.JNS191507

    authors: Feghali J,Xu R,Yang W,Liew J,Tamargo RJ,Marsh EB,Huang J

    更新日期:2019-10-04 00:00:00

  • The history and evolution of transsphenoidal surgery.

    abstract::Initial attempts at transcranial approaches to the pituitary gland in the late 1800s and early 1900s resulted in a mortality rate that was generally considered prohibitive. Schloffer suggested the use of a transsphenoidal route as a safer, alternative approach to the sella turcica. He reported the first successful rem...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章

    doi:10.3171/jns.2001.95.6.1083

    authors: Liu JK,Das K,Weiss MH,Laws ER Jr,Couldwell WT

    更新日期:2001-12-01 00:00:00

  • Fibrinolytic enzyme in the lining walls of chronic subdural hematoma.

    abstract::Active plasmin, available plasmin, and total plasminogen were measured by Enzo-diffusion fibirn plate techniques in 11 cases and level of tissue activator and tissue fibrinolytic activities in another 11 cases with chronic subdural hematoma. The values were too small to be measured in some instances. Anti-plasmin in t...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.48.2.0197

    authors: Ito H,Komai T,Yamamoto S

    更新日期:1978-02-01 00:00:00

  • The neurophysiology and effect of deep brain stimulation in a patient with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism.

    abstract::Parkinsonism caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposure was first identified in intravenous drug users. This neurotoxicant has since been used extensively in nonhuman primates to induce an experimental model of Parkinson disease (PD). In this study, the authors examined the intraoperative p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2008.8.JNS08882

    authors: Christine CW,Langston JW,Turner RS,Starr PA

    更新日期:2009-02-01 00:00:00