Trazodone: a 5-year review of antidepressant efficacy.

Abstract:

:Results from double-blind studies reported since 1981 were reviewed to evaluate trazodone's relative antidepressant efficacy and its safety profile. Trazodone's therapeutic efficacy compared favorably with that of the tricyclic antidepressant (TCA) agents in both endogenous and nonendogenous patients. Data also suggested that trazodone had a more pronounced, earlier anxiolytic action than the TCA agents. Trazodone may be more effective at lower than maximal doses; some studies that used high dosages--starting at 200 mg/day and rapidly titrated doses to as high as 600 mg/day--reported poorer therapeutic responses than did those that employed more conservative dosages. Trazodone therapy generally produced less pronounced anticholinergic effects than did the comparison TCA agent and it is often as sedating as amitriptyline but more sedating than imipramine. Untoward side effects may be reduced by taking trazodone after meals, and by using bedtime dosing. Issues of possible cardiotoxicity and priapism are reviewed briefly. Overall, studies in the past 5 years point to trazodone as being an effective antidepressant agent with a relatively favorable safety profile.

journal_name

Psychopathology

journal_title

Psychopathology

authors

Schatzberg AF

doi

10.1159/000284523

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

48-56

eissn

0254-4962

issn

1423-033X

journal_volume

20 Suppl 1

pub_type

杂志文章,评审
  • Early mental changes in patients with astrocytomas with special reference to anxiety and epilepsy.

    abstract::This study of 47 patients with low- and high-grade gliomas retrospectively focuses on the patients' history with regard to affective and cognitive disturbances as well as to the presence of epileptic manifestations. Early emotional changes with a sudden onset were common in both patient groups, especially panic-like a...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000285074

    authors: Lilja A,Salford LG

    更新日期:1997-01-01 00:00:00

  • The roots of empathy: the shared manifold hypothesis and the neural basis of intersubjectivity.

    abstract::Starting from a neurobiological standpoint, I will propose that our capacity to understand others as intentional agents, far from being exclusively dependent upon mentalistic/linguistic abilities, be deeply grounded in the relational nature of our interactions with the world. According to this hypothesis, an implicit,...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000072786

    authors: Gallese V

    更新日期:2003-07-01 00:00:00

  • The effect of processing speed on cognitive functioning in patients with familial bipolar I disorder and their unaffected relatives.

    abstract:BACKGROUND:Despite increasing evidence of cognitive dysfunctions in bipolar I disorder, there is no specific neuropsychological profile of the disorder. SAMPLING AND METHOD:The aim of the present study was to investigate the effect of processing speed on other cognitive functions in a population-based sample of 32 fam...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000317577

    authors: Antila M,Kieseppä T,Partonen T,Lönnqvist J,Tuulio-Henriksson A

    更新日期:2011-01-01 00:00:00

  • Other Persons: On the Phenomenology of Interpersonal Experience in Schizophrenia (Ancillary Article to EAWE Domain 3).

    abstract::In this paper, we discuss the philosophical and psychopathological background of Domain 3, Other persons, of the Examination of Anomalous World Experiences (EAWE). The EAWE interview aims to describe the manifold phenomena of the schizophrenic lifeworld in all of their concrete and distinctive features, thus complemen...

    journal_title:Psychopathology

    pub_type: 杂志文章,评审

    doi:10.1159/000456037

    authors: Stanghellini G,Ballerini M,Mancini M

    更新日期:2017-01-01 00:00:00

  • Dysphoria: a key for 'understanding' delusion?

    abstract::The 'nonunderstandability' that traditional psychopathology attributes to 'true' delusion does not have a clear demarcation line, but, rather, it is a continuum of various delusional experiences. The attention paid to emotional situations and, specifically, to dysphoria, often contributes to making the delusional phen...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000029146

    authors: Ballerini A,Ballerini AC

    更新日期:2000-07-01 00:00:00

  • Typus melancholicus personality type and the five-factor model of personality.

    abstract::Personality traits are significant factors in the development and course of depression. Apart from the classical five-factor model of personality, other personality constellations, such as Tellenbach's Typus melancholicus, have been described in association with depressive disorder. Several instruments have been devel...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000068596

    authors: Kronmüller KT,Backenstrass M,Kocherscheidt K,Hunt A,Unger J,Fiedler P,Mundt C

    更新日期:2002-11-01 00:00:00

  • Concordance of acute and transient psychoses and cycloid psychoses.

    abstract:OBJECTIVE:We prospectively investigated a sample of 42 patients with acute and transient psychotic disorder (ATPD) as defined by the 10th revision of the International Classification of Diseases (ICD-10; F23) to determine the clinical and demographic features of this entity and its relationship to cycloid psychoses. M...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000049329

    authors: Pillmann F,Haring A,Balzuweit S,Blöink R,Marneros A

    更新日期:2001-11-01 00:00:00

  • Psychopathology in children of patients with panic disorder or animal phobia.

    abstract::Several studies reveal a heightened risk for anxiety and other mental disorders in the offspring of patients with panic disorder and other anxiety disorders. Data on the specific type of transmitted disorders, however, are inconsistent. We investigated the specificity of the relationship between parents' and children'...

    journal_title:Psychopathology

    pub_type: 杂志文章,评审

    doi:10.1159/000029026

    authors: Unnewehr S,Schneider S,Florin I,Margraf J

    更新日期:1998-01-01 00:00:00

  • On the interaction of self-regulation, interoception and pain perception.

    abstract:BACKGROUND:Interoceptive processes were found to be associated with better self-regulation capacities in healthy participants. Further empirical research suggests that interoceptive sensitivity is also important for the perception of pain both in healthy participants and in somatoform patients. Nevertheless, little is ...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000365107

    authors: Weiss S,Sack M,Henningsen P,Pollatos O

    更新日期:2014-01-01 00:00:00

  • Music psychopathology. III. Musical expression and psychiatric disease.

    abstract::Musical expression of the instrumental playing of 61 mentally ill patients and 29 controls recorded several times was assessed by means of a short polarity profile. The performances were reversibly impaired in correlation with the psychopathology. Musical expression followed a systematic variation according to nosolog...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000284415

    authors: Steinberg R,Raith L,Rossnagl G,Eben E

    更新日期:1985-01-01 00:00:00

  • The evolution of some European diagnostic concepts relevant to the category of schizoaffective psychoses.

    abstract::The evolution of the German-Scandinavian concept of cycloid psychosis and of the French concept of 'bouffée délirante' is analyzed. It is stressed that they probably correspond to the same clinical entity, not overlapping with any of the American nosological categories, although sharing a number of features with the o...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000284050

    authors: Maj M

    更新日期:1984-01-01 00:00:00

  • True conversive hallucinations.

    abstract::A case of true conversive hallucinations in a 19-year-old female soldier is described. This phenomenon is rare and should be distinguished from psychotic or dissociative states. ...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000284692

    authors: Spivak B,Livnat E,Weizman A,Rabinowitz S,Mark M

    更新日期:1991-01-01 00:00:00

  • Neuropsychological functioning in schizophrenia patients with first-rank (passivity) symptoms.

    abstract:BACKGROUND:In this study, we conducted a broad investigation of neuropsychological functioning in schizophrenia patients with first-rank (passivity) symptoms (FRS) using standardized cognitive tests. We focused on 3 neuropsychological domains, partly informed by 3 broad hypotheses concerning the pathogenesis of FRS. We...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000187634

    authors: Waters FA,Badcock JC,Dragović M,Jablensky A

    更新日期:2009-01-01 00:00:00

  • Impact of alexithymia on treatment outcome: a naturalistic study of short-term cognitive-behavioral group therapy for panic disorder.

    abstract:BACKGROUND:It is often suggested in the literature that alexithymic patients are less responsive to psychotherapy than nonalexithymic patients. However, few empirical studies have examined this issue. Furthermore, it is unclear whether or not alexithymia itself may improve during psychotherapy. METHODS:Fifty-five cons...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000288639

    authors: Rufer M,Albrecht R,Zaum J,Schnyder U,Mueller-Pfeiffer C,Hand I,Schmidt O

    更新日期:2010-01-01 00:00:00

  • Coexistence of the delusions of infestation and body smell in schizophrenia: a case report.

    abstract::The coexistence of the delusions of infestation and of body smell is reported. In the analysis of a schizophrenic patient, the authors suppose a connection between object loss and the formation of secondary symptoms. Delusions of infestation and/or body smell can be an indication for a careful psychological analysis i...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000284836

    authors: Tényi T,Trixler M

    更新日期:1993-01-01 00:00:00

  • Trazodone, a review of clinical literature and personal experience.

    abstract::The authors summarize the international clinical research performed on trazodone, underlying some pharmacodynamic and therapeutic features of the activity of the drug, the originality of its pharmacodynamic profile and the possibility of using trazodone in a wide range of primary or secondary depression subtypes. Avai...

    journal_title:Psychopathology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000284097

    authors: Agnoli A,De Gregorio M,Dionisio A

    更新日期:1984-01-01 00:00:00

  • Symptom dimensions in obsessive-compulsive disorder: phenomenology and treatment outcomes with exposure and ritual prevention.

    abstract:BACKGROUND:Obsessive-compulsive disorder (OCD) is a severe condition with varied symptom presentations. Currently, the cognitive-behavioral treatment with the most empirical support is exposure and ritual prevention (EX/RP); however, clinical impression and some empirical data suggest that certain OCD symptoms are more...

    journal_title:Psychopathology

    pub_type: 杂志文章,评审

    doi:10.1159/000348582

    authors: Williams MT,Mugno B,Franklin M,Faber S

    更新日期:2013-01-01 00:00:00

  • Psychiatric conditions and the social sciences.

    abstract::Psychiatric disorders have a distinct shape, come in types and are inherent in Homo sapiens. To a social scientist, disorders exist by stipulation: contingent on a psychiatric frame of reference. Their materiality has meaning only in that framework. What is important is what that material might correspond to in a soci...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000086097

    authors: Fabrega H Jr

    更新日期:2005-07-01 00:00:00

  • Objective and subjective extrapyramidal side effects in schizophrenia: their relationships with negative and depressive symptoms.

    abstract::The aim of this study was to show that objective extrapyramidal symptoms (O-EPS) were strongly correlated to negative and depressive symptoms while subjective extrapyramidal symptoms (S-EPS) were not. Ninety-one schizophrenic patients were evaluated by the Extrapyramidal Symptoms Rating Scale (ESRS), Montgomery and As...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000029133

    authors: Dollfus S,Ribeyre JM,Petit M

    更新日期:2000-05-01 00:00:00

  • Psychological perspectives for the development of future diagnostic systems.

    abstract::Psychological aspects of classification broadly refer to mental functions and dysfunctions and are important to consider both in terms of clinical use and the elucidation of pertinent theories. There are a number of concepts crucial to consider for psychologically informed classification, including personality structu...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000065135

    authors: Mundt C

    更新日期:2002-03-01 00:00:00

  • Remediation of Wisconsin Card Sorting Test performance in schizophrenia. A controlled study.

    abstract::Previous studies have shown encouraging plasticity in some schizophrenic patients' Wisconsin Card Sorting Test (WCST) performance while receiving detailed specific instructions on task and reinforcement. The present study examines the efficacy of a modified procedure for WCST administration that bound schizophrenic pa...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000285030

    authors: Stratta P,Mancini F,Mattei P,Daneluzzo E,Bustini M,Casacchia M,Rossi A

    更新日期:1997-03-01 00:00:00

  • Fear of intimacy in women: relationship between attachment styles and depressive symptoms.

    abstract:BACKGROUND:Preoccupied and fearful attachment have both been associated with depressive symptoms, but it is unclear which attachment style is primarily associated with major depression. While preoccupied attachment denotes a focus on relationships as a source of self-validation, fearful attachment involves an avoidance...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000082268

    authors: Reis S,Grenyer BF

    更新日期:2004-11-01 00:00:00

  • Improving Family Functioning to (Hopefully) Improve Treatment Efficacy of Borderline Personality Disorder: An Opportunity Not to Dismiss.

    abstract::People having intimate relationships with persons suffering from borderline personality disorder (BPD) - for instance, members of their family - are likely to be involved in stormy, roller coaster relationships. Thus, they may feel overwhelmed by extreme, unpredictable feelings and situations, even when they do not su...

    journal_title:Psychopathology

    pub_type: 杂志文章,评审

    doi:10.1159/000486603

    authors: Fossati A,Somma A

    更新日期:2018-01-01 00:00:00

  • Koro-like syndrome in a Bedouin man.

    abstract::A case report is presented of a koro-like syndrome in a 34-year-old Bedouin man living in the Negev desert in Israel. The patient's disturbance is accompanied by voyeurism and the onset appears to be related to his sexual practices. This is the first reported case among Bedouins, who are an Arab nomadic tribe living i...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000029037

    authors: Witztum E,Bersudsky Y,Mayodovnik H,Kotler M

    更新日期:1998-01-01 00:00:00

  • Validation of the Barcelona Bipolar Eating Disorder Scale for bipolar patients with eating disturbances.

    abstract:BACKGROUND:Eating disturbances are frequent in bipolar disorder and are associated with poor outcome. Our objective is to assess the psychometric properties of a specific scale for the evaluation of eating disturbances in bipolar patients. SAMPLING AND METHODS:Validation study of 2 groups with a 6-month follow-up (90 ...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000155216

    authors: Torrent C,Vieta E,Garcia-Garcia M,Spanish Working Group for the validation of the Barcelona Bipolar Eating Disorder Scale (BEDS) for bipolar patients with eating disturbances.

    更新日期:2008-01-01 00:00:00

  • Impulsivity in borderline personality disorder: impairment in self-report measures, but not behavioral inhibition.

    abstract:BACKGROUND:Impulsivity is a core feature of borderline personality disorder (BPD). However, previous clinical and experimental studies investigating impulsivity in BPD rendered mixed results. In this study, impulsivity was assessed by self-report scales and behavioral inhibition tasks to compare different data levels. ...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000304174

    authors: Jacob GA,Gutz L,Bader K,Lieb K,Tüscher O,Stahl C

    更新日期:2010-01-01 00:00:00

  • Repetitive Negative Thinking and Its Role in Perinatal Mental Health.

    abstract:BACKGROUND:There is evidence that anxiety is common, perhaps even more prevalent than depression, in the post-partum period. In this review we propose adopting a transdiagnostic approach to perinatal mental health: to delineate psychopathology and identify potential underlying cognitive mechanisms such as repetitive ne...

    journal_title:Psychopathology

    pub_type: 杂志文章,评审

    doi:10.1159/000488114

    authors: Moulds ML,Black MJ,Newby JM,Hirsch CR

    更新日期:2018-01-01 00:00:00

  • The "We-Ness": A Dasein-Analytical Approach to Group Therapy.

    abstract::Beyond the language of medicine and psychology, the essence of many psychopathological experiences remains something that cannot be explained, even if it is possible to perceive it. Phenomenological language in this case must adapt itself to the heart of the lived experience. The phenomenological attitude, in particul...

    journal_title:Psychopathology

    pub_type: 杂志文章,评审

    doi:10.1159/000501954

    authors: Di Petta G,Tittarelli D

    更新日期:2019-01-01 00:00:00

  • Are depressive persons capable of describing changes in their reactions without being able to explain them? A proof of a cybernetic hypothesis of depression.

    abstract:BACKGROUND:Many studies on the autobiographical memory and the explanation of reasons for success and failure proved that persons suffering from major depression tend to overgeneralize. This study examines the hypothesis that changes of reactions caused by a depressive disorder can be described by the affected persons ...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000078088

    authors: Leibetseder M,Kamolz T

    更新日期:2004-03-01 00:00:00

  • Patterns of depression and illness behaviour in general hospital patients.

    abstract::Little interest has been taken in the characteristics of depression in medical and surgical patients and its correlations with syndromes which may be subsumed under the rubric of abnormal illness behaviour. Depressive symptoms and abnormal illness behaviour as measured by self-rating scales were studied among 325 inpa...

    journal_title:Psychopathology

    pub_type: 杂志文章

    doi:10.1159/000284024

    authors: Fava GA,Zielezny M,Pilowsky I,Trombini G

    更新日期:1984-01-01 00:00:00