Hypothesis: a selective advantage for cystic fibrosis heterozygotes.

Abstract:

:European populations have both a particularly long history of pulmonary tuberculosis and extremely high frequencies of cystic fibrosis (CF). While carriers of the recessive gene are asymptomatic for CF disease, their fibroblasts produce excessive amounts of hyaluronic acid, whose role in successful isolation of virulent pathogens appears to be especially adaptive in host resistance to the human strain of Mycobacterium tuberculosis. CF heterozygosity may have been an adaptation to a disease environment once dominated by this infection.

journal_name

Am J Phys Anthropol

authors

Meindl RS

doi

10.1002/ajpa.1330740104

subject

Has Abstract

pub_date

1987-09-01 00:00:00

pages

39-45

issue

1

eissn

0002-9483

issn

1096-8644

journal_volume

74

pub_type

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