Abstract:
:Tourette syndrome (TS) is a neuropsychiatric disorder with childhood onset characterized by chronic motor and vocal tics; however, the current diagnosis of TS patients is subjective, as it is mainly assessed based on the parents' description alongside specific evaluations. The early and accurate diagnosis of TS based on its potential symptoms in children would be of benefit in their future therapy, but reliable diagnoses are difficult due to the lack of objective knowledge of the etiology and pathogenesis of TS. In this study, resting-state electroencephalograms were first collected from 36 patients and 21 healthy controls (HCs); the corresponding resting-state functional networks were then constructed, and the potential differences in network topology between the two groups were extracted by using the topology of the spatial pattern of the network (SPN). Compared to the HCs, the TS patients exhibited decreased frontotemporal/occipital/parietal connectivity. When classifying the two groups, compared to the network properties, the derived SPN features achieved a much higher accuracy of 92.31%. The intrinsic long-range connectivity between the frontal and the temporal/occipital/parietal lobes was damaged in the patient group, and this dysfunctional network pattern might serve as a reliable biomarker to differentiate TS patients from HCs as well as to assess the severity of tic symptoms.
journal_name
Brain Topogrjournal_title
Brain topographyauthors
Duan K,Wu Q,Liao Y,Si Y,Bore JC,Li F,Tao Q,Lin L,Lei W,Hu X,Yao D,Pei C,Zhang T,Huang L,Xu Pdoi
10.1007/s10548-020-00801-5subject
Has Abstractpub_date
2021-01-01 00:00:00pages
78-87issue
1eissn
0896-0267issn
1573-6792pii
10.1007/s10548-020-00801-5journal_volume
34pub_type
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