Mapping the distribution of amobarbital sodium in the intracarotid Wada test by use of Tc-99m HMPAO with SPECT.

Abstract:

:The intracarotid amobarbital sodium, or Wada, test has been used to localize speech and memory function prior to surgical treatment of temporal lobe seizures. The authors mixed technetium-99m hexamethyl-propyleneamine oxime (HMPAO) with amobarbital sodium and injected the mixture in 25 patients with epilepsy. Single photon emission computed tomography (SPECT) of the brain was then performed to determine intracerebral distribution of the amobarbital sodium. Results of SPECT were compared with those of conventional and digital subtraction angiography (DSA). The distribution of Tc-99m HMPAO and, presumably, amobarbital sodium varied from patient to patient. SPECT revealed a statistically different distribution from that predicted with conventional angiography. The distribution also often differed from that of DSA, although the difference was not significant. SPECT revealed infrequent delivery to mesial temporal lobe structures. This emphasizes the need for caution in the use of the intracarotid amobarbital sodium test to predict the outcome of removal of these areas.

journal_name

Radiology

journal_title

Radiology

authors

Jeffery PJ,Monsein LH,Szabo Z,Hart J,Fisher RS,Lesser RP,Debrun GM,Gordon B,Wagner HN Jr,Camargo EE

doi

10.1148/radiology.178.3.1994430

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

847-50

issue

3

eissn

0033-8419

issn

1527-1315

journal_volume

178

pub_type

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