Abstract:
:The intracarotid amobarbital sodium, or Wada, test has been used to localize speech and memory function prior to surgical treatment of temporal lobe seizures. The authors mixed technetium-99m hexamethyl-propyleneamine oxime (HMPAO) with amobarbital sodium and injected the mixture in 25 patients with epilepsy. Single photon emission computed tomography (SPECT) of the brain was then performed to determine intracerebral distribution of the amobarbital sodium. Results of SPECT were compared with those of conventional and digital subtraction angiography (DSA). The distribution of Tc-99m HMPAO and, presumably, amobarbital sodium varied from patient to patient. SPECT revealed a statistically different distribution from that predicted with conventional angiography. The distribution also often differed from that of DSA, although the difference was not significant. SPECT revealed infrequent delivery to mesial temporal lobe structures. This emphasizes the need for caution in the use of the intracarotid amobarbital sodium test to predict the outcome of removal of these areas.
journal_name
Radiologyjournal_title
Radiologyauthors
Jeffery PJ,Monsein LH,Szabo Z,Hart J,Fisher RS,Lesser RP,Debrun GM,Gordon B,Wagner HN Jr,Camargo EEdoi
10.1148/radiology.178.3.1994430subject
Has Abstractpub_date
1991-03-01 00:00:00pages
847-50issue
3eissn
0033-8419issn
1527-1315journal_volume
178pub_type
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